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Protein

Peroxisomal sarcosine oxidase

Gene

PIPOX

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Metabolizes sarcosine, L-pipecolic acid and L-proline.

Catalytic activityi

Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.

Cofactori

FADNote: Binds 1 FAD per subunit.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 3931FADSequence analysisAdd
BLAST

GO - Molecular functioni

  • L-pipecolate oxidase activity Source: UniProtKB
  • sarcosine oxidase activity Source: UniProtKB

GO - Biological processi

  • L-lysine catabolic process to acetyl-CoA via L-pipecolate Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • tetrahydrofolate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal sarcosine oxidase (EC:1.5.3.1, EC:1.5.3.7)
Short name:
PSO
Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene namesi
Name:PIPOX
Synonyms:PSO, SOX
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Peroxisomal sarcosine oxidasePRO_0000213775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261N6-acetyllysineBy similarity
Modified residuei319 – 3191S-8alpha-FAD cysteineCurated

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Kidney and liver.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP79371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi388 – 3903Microbody targeting signalSequence analysis

Sequence similaritiesi

Belongs to the MSOX/MTOX family.Curated

Phylogenomic databases

HOVERGENiHBG023161.
InParanoidiP79371.
KOiK00306.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR006281. SoxA_mon.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01377. soxA_mon. 1 hit.

Sequencei

Sequence statusi: Complete.

P79371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQKDLWDA IVIGAGIQGC FTVYHLVKHR KRILLLEQFF LPHSRGSSHG
60 70 80 90 100
QSRIIRKAYL EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN
110 120 130 140 150
QELKTIQANL SRQRVEHQCL SSEELKQRFP NIRLPRGEVG LLDNSGGVIY
160 170 180 190 200
AYKALRALQD AIRQLGGIVR DGEKVVEINP GLLVTVKTTS RSYQAKSLVI
210 220 230 240 250
TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS QAFPCFLWLG
260 270 280 290 300
LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS
310 320 330 340 350
FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG
360 370 380 390
FKLAPVVGKI LYELSMKLTP SYDLAPFRIS RFPSLGKAHL
Length:390
Mass (Da):44,122
Last modified:May 1, 1997 - v1
Checksum:iE8715FEB607A4335
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82267 mRNA. Translation: AAB48443.1.
RefSeqiNP_001075851.1. NM_001082382.1.
UniGeneiOcu.2126.

Genome annotation databases

GeneIDi100009239.
KEGGiocu:100009239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82267 mRNA. Translation: AAB48443.1.
RefSeqiNP_001075851.1. NM_001082382.1.
UniGeneiOcu.2126.

3D structure databases

ProteinModelPortaliP79371.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009239.
KEGGiocu:100009239.

Organism-specific databases

CTDi51268.

Phylogenomic databases

HOVERGENiHBG023161.
InParanoidiP79371.
KOiK00306.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR006281. SoxA_mon.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
TIGRFAMsiTIGR01377. soxA_mon. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSOX_RABIT
AccessioniPrimary (citable) accession number: P79371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.