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P79371 (SOX_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peroxisomal sarcosine oxidase
Short name=PSO
EC=1.5.3.1
EC=1.5.3.7
Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene names
Name:PIPOX
Synonyms:PSO, SOX
OrganismOryctolagus cuniculus (Rabbit) [Complete proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metabolizes sarcosine, L-pipecolic acid and L-proline.

Catalytic activity

Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.

L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.

Cofactor

Binds 1 FAD per subunit.

Subunit structure

Monomer.

Subcellular location

Peroxisome.

Tissue specificity

Kidney and liver.

Sequence similarities

Belongs to the MSOX/MTOX family.

Ontologies

Keywords
   Cellular componentPeroxisome
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtetrahydrofolate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-pipecolate oxidase activity

Inferred from electronic annotation. Source: EC

sarcosine oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Peroxisomal sarcosine oxidase
PRO_0000213775

Regions

Nucleotide binding9 – 3931FAD Potential
Motif388 – 3903Microbody targeting signal Potential

Amino acid modifications

Modified residue3191S-8alpha-FAD cysteine Probable

Sequences

Sequence LengthMass (Da)Tools
P79371 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: E8715FEB607A4335

FASTA39044,122
        10         20         30         40         50         60 
MAAQKDLWDA IVIGAGIQGC FTVYHLVKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL 

        70         80         90        100        110        120 
EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL 

       130        140        150        160        170        180 
SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP 

       190        200        210        220        230        240 
GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS 

       250        260        270        280        290        300 
QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS 

       310        320        330        340        350        360 
FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI 

       370        380        390 
LYELSMKLTP SYDLAPFRIS RFPSLGKAHL

« Hide

References

[1]"Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase."
Reuber B.E., Karl C., Reimann S.A., Mihalik S.J., Dodt G.
J. Biol. Chem. 272:6766-6776(1997) [PubMed: 9045710] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U82267 mRNA. Translation: AAB48443.1.
RefSeqNP_001075851.1. NM_001082382.1.
UniGeneOcu.2126.

3D structure databases

ProteinModelPortalP79371.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009239.

Organism-specific databases

CTD51268.

Phylogenomic databases

eggNOGmaNOG10720.
HOVERGENHBG023161.

Family and domain databases

InterProIPR006076. FAD-dep_OxRdtase.
IPR006281. SoxA_mon.
[Graphical view]
PfamPF01266. DAO. 1 hit.
[Graphical view]
TIGRFAMsTIGR01377. SoxA_mon. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSOX_RABIT
AccessionPrimary (citable) accession number: P79371
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1997
Last modified: October 19, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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