Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peroxisomal sarcosine oxidase

Gene

PIPOX

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes sarcosine, L-pipecolic acid and L-proline.

Catalytic activityi

Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.

Cofactori

FADNote: Binds 1 FAD per subunit.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 39FADSequence analysisAdd BLAST31

GO - Molecular functioni

  • L-pipecolate oxidase activity Source: UniProtKB
  • sarcosine oxidase activity Source: UniProtKB

GO - Biological processi

  • L-lysine catabolic process to acetyl-CoA via L-pipecolate Source: UniProtKB
  • oxidation-reduction process Source: UniProtKB
  • tetrahydrofolate metabolic process Source: InterPro

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal sarcosine oxidase (EC:1.5.3.1, EC:1.5.3.7)
Short name:
PSO
Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene namesi
Name:PIPOX
Synonyms:PSO, SOX
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137751 – 390Peroxisomal sarcosine oxidaseAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysineBy similarity1
Modified residuei319S-8alpha-FAD cysteineCurated1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP79371

Expressioni

Tissue specificityi

Kidney and liver.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP79371
SMRiP79371
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi388 – 390Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the MSOX/MTOX family.Curated

Phylogenomic databases

HOVERGENiHBG023161
InParanoidiP79371
KOiK00306

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR006281 SoxA_mon
PfamiView protein in Pfam
PF01266 DAO, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01377 soxA_mon, 1 hit

Sequencei

Sequence statusi: Complete.

P79371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQKDLWDA IVIGAGIQGC FTVYHLVKHR KRILLLEQFF LPHSRGSSHG
60 70 80 90 100
QSRIIRKAYL EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN
110 120 130 140 150
QELKTIQANL SRQRVEHQCL SSEELKQRFP NIRLPRGEVG LLDNSGGVIY
160 170 180 190 200
AYKALRALQD AIRQLGGIVR DGEKVVEINP GLLVTVKTTS RSYQAKSLVI
210 220 230 240 250
TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS QAFPCFLWLG
260 270 280 290 300
LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS
310 320 330 340 350
FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG
360 370 380 390
FKLAPVVGKI LYELSMKLTP SYDLAPFRIS RFPSLGKAHL
Length:390
Mass (Da):44,122
Last modified:May 1, 1997 - v1
Checksum:iE8715FEB607A4335
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82267 mRNA Translation: AAB48443.1
RefSeqiNP_001075851.1, NM_001082382.1
UniGeneiOcu.2126

Genome annotation databases

GeneIDi100009239
KEGGiocu:100009239

Similar proteinsi

Entry informationi

Entry nameiSOX_RABIT
AccessioniPrimary (citable) accession number: P79371
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health