Reviewed, UniProtKB/Swiss-Prot P79371 (SOX_RABIT)

Names and origin

Protein names

Recommended name:
    Peroxisomal sarcosine oxidase
      Short name=PSO
    EC=1.5.3.1
    EC=1.5.3.7
Alternative name(s):
    L-pipecolate oxidase
    L-pipecolic acid oxidase

Gene names

Name:	PIPOX
Synonyms:	PSO, SOX

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Metabolizes sarcosine, L-pipecolic acid and L-proline.
Catalytic activity	Sarcosine + H(2)O + O(2) = glycine + formaldehyde + H(2)O(2). L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2).
Cofactor	Binds 1 FAD per subunit.
Subunit structure	Monomer.
Subcellular location	Peroxisome.
Tissue specificity	Kidney and liver.
Sequence similarities	Belongs to the MSOX/MTOX family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-pipecolate oxidase activity Inferred from electronic annotation. Source: EC sarcosine oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Peroxisomal sarcosine oxidase		PRO_0000213775
Regions
	Nucleotide binding	9 – 39	31	FAD Potential
	Motif	388 – 390	3	Microbody targeting signal Potential
Amino acid modifications
	Modified residue	319	1	S-8alpha-FAD cysteine Probable

Sequences

	Sequence		Length	Mass (Da)
	P79371-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: E8715FEB607A4335	FASTA	390	44,122
	10 20 30 40 50 60 MAAQKDLWDA IVIGAGIQGC FTVYHLVKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL 70 80 90 100 110 120 EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL 130 140 150 160 170 180 SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP 190 200 210 220 230 240 GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS 250 260 270 280 290 300 QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS 310 320 330 340 350 360 FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI 370 380 390 LYELSMKLTP SYDLAPFRIS RFPSLGKAHL

References

[1]	"Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase." Reuber B.E., Karl C., Reimann S.A., Mihalik S.J., Dodt G. J. Biol. Chem. 272:6766-6776(1997) [PubMed: 9045710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U82267 mRNA. Translation: AAB48443.1.
RefSeq	NP_001075851.1.
UniGene	Ocu.2126
3D structure databases
HSSP	HSSP built from PDB template 1EL5 based on UniProtKB P40859.
ModBase	Search...
Genome annotation databases
GeneID	100009239.
Phylogenomic databases
HOVERGEN	P79371.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR006281. SoxA_mon. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR01377. soxA_mon. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SOX_RABIT

Accession

Primary (citable) accession number: P79371

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	May 1, 1997
Last modified:	November 25, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)