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Protein

Regulator of G-protein signaling 20

Gene

RGS20

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionSignal transduction inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 20
Short name:
RGS20
Alternative name(s):
Retina-specific regulator of G-protein signaling 1
Short name:
Ret-RGS1
Gene namesi
Name:RGS20
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:33919. RGS20.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002042321 – 374Regulator of G-protein signaling 20Add BLAST374

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
N- and O-glycosylated in synapsomal membranes.By similarity
Serine phosphorylated in synapsomal membranes.By similarity
Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP79348.
PRIDEiP79348.

Expressioni

Tissue specificityi

Retinal-specific. Expressed throughout the retina, including photoreceptors.

Gene expression databases

BgeeiENSBTAG00000003454.
ExpressionAtlasiP79348. baseline and differential.

Interactioni

Subunit structurei

Forms a complex with G(alpha)z/i2 subunits and mu-opioid receptors; the formation of this complex results in mu-opioid receptor desensitization. Interacts with OPRM1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004487.

Structurei

3D structure databases

ProteinModelPortaliP79348.
SMRiP79348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 364RGSPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi193 – 205Poly-CysAdd BLAST13

Phylogenomic databases

eggNOGiKOG3589. Eukaryota.
ENOG410YMJD. LUCA.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiP79348.
OMAiMPPMGSE.
OrthoDBiEOG091G0BDG.
TreeFamiTF315837.

Family and domain databases

InterProiView protein in InterPro
IPR016137. RGS.
IPR036305. RGS_sf.
PfamiView protein in Pfam
PF00615. RGS. 1 hit.
PRINTSiPR01301. RGSPROTEIN.
SMARTiView protein in SMART
SM00315. RGS. 1 hit.
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiView protein in PROSITE
PS50132. RGS. 1 hit.

Sequencei

Sequence statusi: Complete.

P79348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLSQDNQQ GHQKHFSRPS RRIQFLPPPW TEAYNVNVHQ TVENEGCATA
60 70 80 90 100
MHNVKLLGSP AAPTLLSLLS GTLSGFARFF ALLLRRPPPE APLRRRDFSA
110 120 130 140 150
LIPALPAAVL SPGHEERPGR LSLLLRAALA LPGRPPGGRL PREVDASAGQ
160 170 180 190 200
SSSIPPMGSE WMEMRKRPVC AAQEPTACAP GQPGVENQGS NACCFCWCCC
210 220 230 240 250
CSCSCLTVRN QEEQRLRRTS YEARTEDLPT CEESPGPTLE EASAWAQSFD
260 270 280 290 300
KLMLTPAGRN AFREFLRTEF SEENMLFWMA CEELKKEANK ATIEEKARII
310 320 330 340 350
YEDYISILSP KEVSLDSRVR ETINRSMAEP SRNIFDDAQL QIYTLMHRDS
360 370
YPRFMNSALY KDLLRSLSEK AVEA
Length:374
Mass (Da):41,917
Last modified:January 1, 1998 - v2
Checksum:i23B39C2DC4A0617F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89254 mRNA. Translation: AAC48721.1.
RefSeqiXP_005215480.1. XM_005215423.3.
UniGeneiBt.47430.

Genome annotation databases

EnsembliENSBTAT00000004487; ENSBTAP00000004487; ENSBTAG00000003454.
GeneIDi614441.

Similar proteinsi

Entry informationi

Entry nameiRGS20_BOVIN
AccessioniPrimary (citable) accession number: P79348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome