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Protein

Acrosin

Gene

bovine proacrosine

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.UniRule annotation

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Charge relay systemUniRule annotation1
Active sitei103Charge relay systemUniRule annotation1
Active sitei201Charge relay systemUniRule annotation1

GO - Molecular functioni

  • amidase activity Source: UniProtKB
  • copper ion binding Source: UniProtKB
  • drug binding Source: UniProtKB
  • fucose binding Source: UniProtKB
  • mannose binding Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • acrosome reaction Source: UniProtKB
  • activation of adenylate cyclase activity Source: UniProtKB
  • single fertilization Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BRENDAi3.4.21.10 908

Protein family/group databases

MEROPSiS01.223

Names & Taxonomyi

Protein namesi
Recommended name:
AcrosinUniRule annotation (EC:3.4.21.10UniRule annotation)
Gene namesi
Name:bovine proacrosineImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiP79343

Interactioni

Subunit structurei

Heavy chain (catalytic) and a light chain linked by two disulfide bonds.UniRule annotation

Protein-protein interaction databases

CORUMiP79343
IntActiP79343, 1 interactor
MINTiP79343

Structurei

3D structure databases

ProteinModelPortaliP79343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 251Peptidase S1InterPro annotationAdd BLAST249

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000033792
HOVERGENiHBG013304

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR012267 Pept_S1A_acrosin
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PANTHERiPTHR24252 PTHR24252, 1 hit
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001141 Acrosin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

P79343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIIGGQDAA HGSWPWMVSL QIFTYHNNRR YHVCWGLLLN AHWLLTAAHC
60 70 80 90 100
FRIKKKVTDW RLIFGAKEVE WGSNKPVKPP LQERYVEKII IHEKYSASSE
110 120 130 140 150
ANDIALIKIT PPVICGHFIG PGCLPQFRAG PPRVPQTCWV AGWGFLRENA
160 170 180 190 200
RRTSPVLQEA HVDLIDLDLC NSTRWYNGRI RSTNVCAGYP EGKIDTCQGD
210 220 230 240 250
SGGPLMCKDS VENSYVVVGI TSWGVGCSRA KRPGVYTSTW SYLNWIASKI
260 270 280 290 300
GSNTVHMIQL PTAPPASTPA AQASPGSVQP SIRPPWFFQH VPQPPPSQQA
310 320 330 340 350
IAVAQPSRPS SPRPSVPPAP RPPRPPPPQP STRPPQALSF AKRLQQLIEV
360 370
LKGKTFLNEK SNYEMETTGL PGQHASS
Length:377
Mass (Da):41,722
Last modified:May 1, 1997 - v1
Checksum:iDF0BB014860430CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68212 Genomic DNA Translation: CAA48294.1
UniGeneiBt.45050

Similar proteinsi

Entry informationi

Entry nameiP79343_BOVIN
AccessioniPrimary (citable) accession number: P79343
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health