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Protein

Acrosin

Gene

bovine proacrosine

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.UniRule annotation

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Charge relay systemUniRule annotation
Active sitei103 – 1031Charge relay systemUniRule annotation
Active sitei201 – 2011Charge relay systemUniRule annotation

GO - Molecular functioni

  • amidase activity Source: UniProtKB
  • copper ion binding Source: UniProtKB
  • drug binding Source: UniProtKB
  • fucose binding Source: UniProtKB
  • mannose binding Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • acrosome reaction Source: UniProtKB
  • activation of adenylate cyclase activity Source: UniProtKB
  • single fertilization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BRENDAi3.4.21.10. 908.

Protein family/group databases

MEROPSiS01.223.

Names & Taxonomyi

Protein namesi
Recommended name:
AcrosinUniRule annotation (EC:3.4.21.10UniRule annotation)
Gene namesi
Name:bovine proacrosineImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

GO - Cellular componenti

  • acrosomal matrix Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiP79343.

Interactioni

Subunit structurei

Heavy chain (catalytic) and a light chain linked by two disulfide bonds.UniRule annotation

Protein-protein interaction databases

IntActiP79343. 1 interaction.
MINTiMINT-6825120.

Structurei

3D structure databases

ProteinModelPortaliP79343.
SMRiP79343. Positions 3-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 251249Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotationSAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033792.
HOVERGENiHBG013304.

Family and domain databases

InterProiIPR012267. Pept_S1A_acrosin.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24252. PTHR24252. 1 hit.
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001141. Acrosin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIIGGQDAA HGSWPWMVSL QIFTYHNNRR YHVCWGLLLN AHWLLTAAHC
60 70 80 90 100
FRIKKKVTDW RLIFGAKEVE WGSNKPVKPP LQERYVEKII IHEKYSASSE
110 120 130 140 150
ANDIALIKIT PPVICGHFIG PGCLPQFRAG PPRVPQTCWV AGWGFLRENA
160 170 180 190 200
RRTSPVLQEA HVDLIDLDLC NSTRWYNGRI RSTNVCAGYP EGKIDTCQGD
210 220 230 240 250
SGGPLMCKDS VENSYVVVGI TSWGVGCSRA KRPGVYTSTW SYLNWIASKI
260 270 280 290 300
GSNTVHMIQL PTAPPASTPA AQASPGSVQP SIRPPWFFQH VPQPPPSQQA
310 320 330 340 350
IAVAQPSRPS SPRPSVPPAP RPPRPPPPQP STRPPQALSF AKRLQQLIEV
360 370
LKGKTFLNEK SNYEMETTGL PGQHASS
Length:377
Mass (Da):41,722
Last modified:May 1, 1997 - v1
Checksum:iDF0BB014860430CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68212 Genomic DNA. Translation: CAA48294.1.
UniGeneiBt.45050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68212 Genomic DNA. Translation: CAA48294.1.
UniGeneiBt.45050.

3D structure databases

ProteinModelPortaliP79343.
SMRiP79343. Positions 3-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP79343. 1 interaction.
MINTiMINT-6825120.

Protein family/group databases

MEROPSiS01.223.

Proteomic databases

PRIDEiP79343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000033792.
HOVERGENiHBG013304.

Enzyme and pathway databases

BRENDAi3.4.21.10. 908.

Miscellaneous databases

NextBioi20804890.

Family and domain databases

InterProiIPR012267. Pept_S1A_acrosin.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24252. PTHR24252. 1 hit.
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001141. Acrosin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Keime S.
    Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. "The structures of the bovine and porcine proacrosin genes and their conservation during mammals."
    Adham I.M., Kremling H., Nieter S., Zimmermann S., Hummel M., Schroeter U., Engel W.
    Biol. Chem. Hoppe-Seyler 377:261-265(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiP79343_BOVIN
AccessioniPrimary (citable) accession number: P79343
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.