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Protein

Plasminogen activator inhibitor 1

Gene

SERPINE1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei369 – 370Reactive bond2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1
Short name:
PAI
Short name:
PAI-1
Alternative name(s):
Endothelial plasminogen activator inhibitor
Serpin E1
Gene namesi
Name:SERPINE1
Synonyms:PAI1, PLANH1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003250224 – 402Plasminogen activator inhibitor 1Add BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)Sequence analysis1
Glycosylationi352N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP79335.
PRIDEiP79335.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP79335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG106493.
InParanoidiP79335.
KOiK03982.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMSLVFACL AMGLALTFAE GSASSHHQSL AARLATDFGV KVFRQVVQAS
60 70 80 90 100
KDRNVVFSPY GVASVLAMLQ LTTAGDTQQQ IQEAMQFKIE EKGMAPALRQ
110 120 130 140 150
LYKELMGPWN KDEISTADAI FVQRDLKLVQ GFMPYFFRLF RTTVKQVDFS
160 170 180 190 200
EMDRARFIIN DWVKRHTKGM INDLLGQGAV DQLTRLVLVN ALYFNGQWKT
210 220 230 240 250
PFPEKSTHHR LFHKSDGSTV SVPMMAQTNK FNYTEFSTPD GHYYDILELP
260 270 280 290 300
YHGNTLSMFI AAPYEKEVPL SALTSILDAQ LISQWKGNMT RLTRLLVLPK
310 320 330 340 350
FSLESEVDLR RPLENLGMTD MFRPNQADFS SLSDQELLYM SQALQKVKIE
360 370 380 390 400
VNESGTVASS STAIIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM

EP
Length:402
Mass (Da):45,450
Last modified:May 1, 1997 - v1
Checksum:i13F60E5F4F8FE405
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11347 mRNA. Translation: CAA72182.1.
RefSeqiNP_999075.1. NM_213910.1.
UniGeneiSsc.9781.

Genome annotation databases

GeneIDi396945.
KEGGissc:396945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11347 mRNA. Translation: CAA72182.1.
RefSeqiNP_999075.1. NM_213910.1.
UniGeneiSsc.9781.

3D structure databases

ProteinModelPortaliP79335.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI04.020.

Proteomic databases

PeptideAtlasiP79335.
PRIDEiP79335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396945.
KEGGissc:396945.

Organism-specific databases

CTDi5054.

Phylogenomic databases

HOVERGENiHBG106493.
InParanoidiP79335.
KOiK03982.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAI1_PIG
AccessioniPrimary (citable) accession number: P79335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.