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Protein

Aromatase 3

Gene

CYP19A3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase 3 (EC:1.14.14.14)
Alternative name(s):
CYPXIXA3
Cytochrome P-450AROM
Cytochrome P450 19 type III
Estrogen synthase
Gene namesi
Name:CYP19A3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Aromatase 3PRO_0000051960Add
BLAST

Expressioni

Tissue specificityi

Ovary.

Gene expression databases

GenevisibleiP79304. SS.

Structurei

3D structure databases

ProteinModelPortaliP79304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.
InParanoidiP79304.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLEMLNPMN ISSMVSEAVL FGSIAILLLI GLLLWVWNYE DTSSIPGPGY
60 70 80 90 100
FLGIGPLISH FRFLWMGIGS ACNYYNKMYG EFMRVWIGGE ETLIISKSSS
110 120 130 140 150
IFHIMKHNHY TCRFGSKLGL ECIGMHEKGI MFNNNPALWK AVRPFFTKAL
160 170 180 190 200
SGPGLVRMVT VCADSITKHL DKLEEVRNDL GYVDVLTLMR RIMLDTSNNL
210 220 230 240 250
FLGIPLDESA LVHKVQGYFD AWQALLLKPD IFFKISWLYR KYEKSVKDLK
260 270 280 290 300
DAMEILIEEK RHRISTAEKL EDSMDFTTQL IFAEKRGELT KENVNQCVLE
310 320 330 340 350
MMIAAPDTMS ITVFFMLFLI ANHPQVEEEL MKEIYTVVGE RDIRNDDMQK
360 370 380 390 400
LKVVENFIYE SMRYQPVVDF VMRKALEDDV IDGYPVKKGT NIILNIGRMH
410 420 430 440 450
RLEFFPKPNE FTLENFAKNV PYRYFQPFGF GPRACAGKYI AMVMMKVILV
460 470 480 490 500
TLLRRFQVQT QQGQCVEKMQ KKNDLSLHPH ETSGLLEMIF IPRNSDKCLE

H
Length:501
Mass (Da):57,915
Last modified:August 1, 1999 - v2
Checksum:iAFC6C150BD6E41F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92246 mRNA. Translation: AAB51388.1.
AH006584 Genomic DNA. Translation: AAC48733.1.
RefSeqiNP_999596.1. NM_214431.1.
UniGeneiSsc.14541.

Genome annotation databases

GeneIDi403333.
KEGGissc:403333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92246 mRNA. Translation: AAB51388.1.
AH006584 Genomic DNA. Translation: AAC48733.1.
RefSeqiNP_999596.1. NM_214431.1.
UniGeneiSsc.14541.

3D structure databases

ProteinModelPortaliP79304.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403333.
KEGGissc:403333.

Organism-specific databases

CTDi403333.

Phylogenomic databases

HOVERGENiHBG050750.
InParanoidiP79304.
KOiK07434.

Gene expression databases

GenevisibleiP79304. SS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Functional ovarian and placental isoforms of porcine aromatase."
    Corbin C.J., Khalil M.W., Conley A.J.
    Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Ovary.
  2. "Porcine aromatases: studies on tissue-specific, functionally distinct isozymes from a single gene?"
    Conley A.J., Corbin C.J., Smith T., Hinshelwood M., Liu Z., Simpson E.
    J. Steroid Biochem. Mol. Biol. 61:407-413(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Ovary.
  3. "Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase."
    Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A.
    DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-96.
    Tissue: Liver.

Entry informationi

Entry nameiCP193_PIG
AccessioniPrimary (citable) accession number: P79304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1999
Last modified: June 24, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.