Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P79304

- CP193_PIG

UniProt

P79304 - CP193_PIG

Protein

Aromatase 3

Gene

CYP19A3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (01 Aug 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase 3 (EC:1.14.14.14)
    Alternative name(s):
    CYPXIXA3
    Cytochrome P-450AROM
    Cytochrome P450 19 type III
    Estrogen synthase
    Gene namesi
    Name:CYP19A3
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Aromatase 3PRO_0000051960Add
    BLAST

    Expressioni

    Tissue specificityi

    Ovary.

    Structurei

    3D structure databases

    ProteinModelPortaliP79304.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.
    KOiK07434.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79304-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLEMLNPMN ISSMVSEAVL FGSIAILLLI GLLLWVWNYE DTSSIPGPGY    50
    FLGIGPLISH FRFLWMGIGS ACNYYNKMYG EFMRVWIGGE ETLIISKSSS 100
    IFHIMKHNHY TCRFGSKLGL ECIGMHEKGI MFNNNPALWK AVRPFFTKAL 150
    SGPGLVRMVT VCADSITKHL DKLEEVRNDL GYVDVLTLMR RIMLDTSNNL 200
    FLGIPLDESA LVHKVQGYFD AWQALLLKPD IFFKISWLYR KYEKSVKDLK 250
    DAMEILIEEK RHRISTAEKL EDSMDFTTQL IFAEKRGELT KENVNQCVLE 300
    MMIAAPDTMS ITVFFMLFLI ANHPQVEEEL MKEIYTVVGE RDIRNDDMQK 350
    LKVVENFIYE SMRYQPVVDF VMRKALEDDV IDGYPVKKGT NIILNIGRMH 400
    RLEFFPKPNE FTLENFAKNV PYRYFQPFGF GPRACAGKYI AMVMMKVILV 450
    TLLRRFQVQT QQGQCVEKMQ KKNDLSLHPH ETSGLLEMIF IPRNSDKCLE 500
    H 501
    Length:501
    Mass (Da):57,915
    Last modified:August 1, 1999 - v2
    Checksum:iAFC6C150BD6E41F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92246 mRNA. Translation: AAB51388.1.
    AH006584 Genomic DNA. Translation: AAC48733.1.
    RefSeqiNP_999596.1. NM_214431.1.
    UniGeneiSsc.14541.

    Genome annotation databases

    GeneIDi403333.
    KEGGissc:403333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U92246 mRNA. Translation: AAB51388.1 .
    AH006584 Genomic DNA. Translation: AAC48733.1 .
    RefSeqi NP_999596.1. NM_214431.1.
    UniGenei Ssc.14541.

    3D structure databases

    ProteinModelPortali P79304.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403333.
    KEGGi ssc:403333.

    Organism-specific databases

    CTDi 403333.

    Phylogenomic databases

    HOVERGENi HBG050750.
    KOi K07434.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional ovarian and placental isoforms of porcine aromatase."
      Corbin C.J., Khalil M.W., Conley A.J.
      Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Ovary.
    2. "Porcine aromatases: studies on tissue-specific, functionally distinct isozymes from a single gene?"
      Conley A.J., Corbin C.J., Smith T., Hinshelwood M., Liu Z., Simpson E.
      J. Steroid Biochem. Mol. Biol. 61:407-413(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Ovary.
    3. "Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase."
      Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A.
      DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-96.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP193_PIG
    AccessioniPrimary (citable) accession number: P79304
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1999
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3