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P79304 (CP193_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase 3

EC=1.14.14.14
Alternative name(s):
CYPXIXA3
Cytochrome P-450AROM
Cytochrome P450 19 type III
Estrogen synthase
Gene names
Name:CYP19A3
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Tissue specificity

Ovary.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Aromatase 3
PRO_0000051960

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P79304 [UniParc].

Last modified August 1, 1999. Version 2.
Checksum: AFC6C150BD6E41F9

FASTA50157,915
        10         20         30         40         50         60 
MVLEMLNPMN ISSMVSEAVL FGSIAILLLI GLLLWVWNYE DTSSIPGPGY FLGIGPLISH 

        70         80         90        100        110        120 
FRFLWMGIGS ACNYYNKMYG EFMRVWIGGE ETLIISKSSS IFHIMKHNHY TCRFGSKLGL 

       130        140        150        160        170        180 
ECIGMHEKGI MFNNNPALWK AVRPFFTKAL SGPGLVRMVT VCADSITKHL DKLEEVRNDL 

       190        200        210        220        230        240 
GYVDVLTLMR RIMLDTSNNL FLGIPLDESA LVHKVQGYFD AWQALLLKPD IFFKISWLYR 

       250        260        270        280        290        300 
KYEKSVKDLK DAMEILIEEK RHRISTAEKL EDSMDFTTQL IFAEKRGELT KENVNQCVLE 

       310        320        330        340        350        360 
MMIAAPDTMS ITVFFMLFLI ANHPQVEEEL MKEIYTVVGE RDIRNDDMQK LKVVENFIYE 

       370        380        390        400        410        420 
SMRYQPVVDF VMRKALEDDV IDGYPVKKGT NIILNIGRMH RLEFFPKPNE FTLENFAKNV 

       430        440        450        460        470        480 
PYRYFQPFGF GPRACAGKYI AMVMMKVILV TLLRRFQVQT QQGQCVEKMQ KKNDLSLHPH 

       490        500 
ETSGLLEMIF IPRNSDKCLE H 

« Hide

References

[1]"Functional ovarian and placental isoforms of porcine aromatase."
Corbin C.J., Khalil M.W., Conley A.J.
Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Ovary.
[2]"Porcine aromatases: studies on tissue-specific, functionally distinct isozymes from a single gene?"
Conley A.J., Corbin C.J., Smith T., Hinshelwood M., Liu Z., Simpson E.
J. Steroid Biochem. Mol. Biol. 61:407-413(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Ovary.
[3]"Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase."
Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A.
DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-96.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U92246 mRNA. Translation: AAB51388.1.
AH006584 Genomic DNA. Translation: AAC48733.1.
RefSeqNP_999596.1. NM_214431.1.
UniGeneSsc.14541.

3D structure databases

ProteinModelPortalP79304.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403333.
KEGGssc:403333.

Organism-specific databases

CTD403333.

Phylogenomic databases

HOVERGENHBG050750.
KOK07434.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP193_PIG
AccessionPrimary (citable) accession number: P79304
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1999
Last modified: January 22, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families