P79304 (CP193_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 19 type III
EC=1.14.14.1

Alternative name(s):
Aromatase
CYPXIXA3
Cytochrome P-450AROM
Estrogen synthase

Gene names

Name:

CYP19A3

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Tissue specificity	Ovary.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Cytochrome P450 19 type III		PRO_0000051960
Sites
	Metal binding	435	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79304 [UniParc]. Last modified August 1, 1999. Version 2. Checksum: AFC6C150BD6E41F9	FASTA	501	57,915
	10 20 30 40 50 60 MVLEMLNPMN ISSMVSEAVL FGSIAILLLI GLLLWVWNYE DTSSIPGPGY FLGIGPLISH 70 80 90 100 110 120 FRFLWMGIGS ACNYYNKMYG EFMRVWIGGE ETLIISKSSS IFHIMKHNHY TCRFGSKLGL 130 140 150 160 170 180 ECIGMHEKGI MFNNNPALWK AVRPFFTKAL SGPGLVRMVT VCADSITKHL DKLEEVRNDL 190 200 210 220 230 240 GYVDVLTLMR RIMLDTSNNL FLGIPLDESA LVHKVQGYFD AWQALLLKPD IFFKISWLYR 250 260 270 280 290 300 KYEKSVKDLK DAMEILIEEK RHRISTAEKL EDSMDFTTQL IFAEKRGELT KENVNQCVLE 310 320 330 340 350 360 MMIAAPDTMS ITVFFMLFLI ANHPQVEEEL MKEIYTVVGE RDIRNDDMQK LKVVENFIYE 370 380 390 400 410 420 SMRYQPVVDF VMRKALEDDV IDGYPVKKGT NIILNIGRMH RLEFFPKPNE FTLENFAKNV 430 440 450 460 470 480 PYRYFQPFGF GPRACAGKYI AMVMMKVILV TLLRRFQVQT QQGQCVEKMQ KKNDLSLHPH 490 500 ETSGLLEMIF IPRNSDKCLE H

References

[1]	"Functional ovarian and placental isoforms of porcine aromatase." Corbin C.J., Khalil M.W., Conley A.J. Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Ovary.
[2]	"Porcine aromatases: studies on tissue-specific, functionally distinct isozymes from a single gene?" Conley A.J., Corbin C.J., Smith T., Hinshelwood M., Liu Z., Simpson E. J. Steroid Biochem. Mol. Biol. 61:407-413(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Ovary.
[3]	"Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase." Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A. DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-96. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U92246 mRNA. Translation: AAB51388.1. AH006584 Genomic DNA. Translation: AAC48733.1.
RefSeq	NP_999596.1. NM_214431.1.
UniGene	Ssc.14541.
3D structure databases
ProteinModelPortal	P79304.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403333.
KEGG	ssc:403333.
Organism-specific databases
CTD	403333.
Phylogenomic databases
HOVERGEN	HBG050750.
KO	K07434.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP193_PIG

Accession

Primary (citable) accession number: P79304

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1999
Last modified:	April 3, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program