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P79304

- CP193_PIG

UniProt

P79304 - CP193_PIG

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Protein

Aromatase 3

Gene
CYP19A3
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase 3 (EC:1.14.14.14)
Alternative name(s):
CYPXIXA3
Cytochrome P-450AROM
Cytochrome P450 19 type III
Estrogen synthase
Gene namesi
Name:CYP19A3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Aromatase 3PRO_0000051960Add
BLAST

Expressioni

Tissue specificityi

Ovary.

Structurei

3D structure databases

ProteinModelPortaliP79304.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG050750.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79304-1 [UniParc]FASTAAdd to Basket

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MVLEMLNPMN ISSMVSEAVL FGSIAILLLI GLLLWVWNYE DTSSIPGPGY    50
FLGIGPLISH FRFLWMGIGS ACNYYNKMYG EFMRVWIGGE ETLIISKSSS 100
IFHIMKHNHY TCRFGSKLGL ECIGMHEKGI MFNNNPALWK AVRPFFTKAL 150
SGPGLVRMVT VCADSITKHL DKLEEVRNDL GYVDVLTLMR RIMLDTSNNL 200
FLGIPLDESA LVHKVQGYFD AWQALLLKPD IFFKISWLYR KYEKSVKDLK 250
DAMEILIEEK RHRISTAEKL EDSMDFTTQL IFAEKRGELT KENVNQCVLE 300
MMIAAPDTMS ITVFFMLFLI ANHPQVEEEL MKEIYTVVGE RDIRNDDMQK 350
LKVVENFIYE SMRYQPVVDF VMRKALEDDV IDGYPVKKGT NIILNIGRMH 400
RLEFFPKPNE FTLENFAKNV PYRYFQPFGF GPRACAGKYI AMVMMKVILV 450
TLLRRFQVQT QQGQCVEKMQ KKNDLSLHPH ETSGLLEMIF IPRNSDKCLE 500
H 501
Length:501
Mass (Da):57,915
Last modified:August 1, 1999 - v2
Checksum:iAFC6C150BD6E41F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92246 mRNA. Translation: AAB51388.1.
AH006584 Genomic DNA. Translation: AAC48733.1.
RefSeqiNP_999596.1. NM_214431.1.
UniGeneiSsc.14541.

Genome annotation databases

GeneIDi403333.
KEGGissc:403333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92246 mRNA. Translation: AAB51388.1 .
AH006584 Genomic DNA. Translation: AAC48733.1 .
RefSeqi NP_999596.1. NM_214431.1.
UniGenei Ssc.14541.

3D structure databases

ProteinModelPortali P79304.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403333.
KEGGi ssc:403333.

Organism-specific databases

CTDi 403333.

Phylogenomic databases

HOVERGENi HBG050750.
KOi K07434.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional ovarian and placental isoforms of porcine aromatase."
    Corbin C.J., Khalil M.W., Conley A.J.
    Mol. Cell. Endocrinol. 113:29-37(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Ovary.
  2. "Porcine aromatases: studies on tissue-specific, functionally distinct isozymes from a single gene?"
    Conley A.J., Corbin C.J., Smith T., Hinshelwood M., Liu Z., Simpson E.
    J. Steroid Biochem. Mol. Biol. 61:407-413(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Ovary.
  3. "Closely related genes encode developmental and tissue isoforms of porcine cytochrome P450 aromatase."
    Choi I., Troyer D.L., Cornwell D.L., Kirby-Dobbels K.R., Collante W.R., Simmen F.A.
    DNA Cell Biol. 16:769-777(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-96.
    Tissue: Liver.

Entry informationi

Entry nameiCP193_PIG
AccessioniPrimary (citable) accession number: P79304
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1999
Last modified: January 22, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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