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P79303 (UGPA_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name=UDPGP
Short name=UGPase
Gene names
Name:UGP2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activity

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Subunit structure

Homooctamer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the UDPGP type 1 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionNucleotidyltransferase
Transferase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionUTP:glucose-1-phosphate uridylyltransferase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508UTP--glucose-1-phosphate uridylyltransferase
PRO_0000185754

Regions

Region457 – 50852Oligomerization By similarity

Sites

Active site3961 By similarity
Metal binding1271Magnesium By similarity
Metal binding2531Magnesium By similarity

Amino acid modifications

Modified residue131Phosphoserine By similarity
Modified residue4381N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P79303 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 327F66CD91783965

FASTA50856,953
        10         20         30         40         50         60 
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH TKKDLDGFRK 

        70         80         90        100        110        120 
LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS 

       130        140        150        160        170        180 
MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYNTDVPLV LMNSFNTDED TKKILQKYNH 

       190        200        210        220        230        240 
CRVKIYTFNQ SRYPRINKES LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI 

       250        260        270        280        290        300 
GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGRPCEFVM EATNKARADV KGGTLTQYEG 

       310        320        330        340        350        360 
KLRLVEIAQV PKPHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNPKTLD 

       370        380        390        400        410        420 
GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 

       430        440        450        460        470        480 
KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIX 

       490        500 
NHGDRIDIPP GAVLENKIVS GNLRILDH

« Hide

References

[1]"cDNA sequencing of the porcine UDP glucose pyrophosphorylase gene."
Looft C., Paul S.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X99312 mRNA. Translation: CAA67690.1.
RefSeqNP_999145.1. NM_213980.1.
UniGeneSsc.5264.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000008931.

Proteomic databases

PaxDbP79303.
PRIDEP79303.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397040.
KEGGssc:397040.

Organism-specific databases

CTD7360.

Phylogenomic databases

eggNOGCOG4284.
HOGENOMHOG000113618.
HOVERGENHBG055396.
KOK00963.
OrthoDBEOG4RFKSC.

Family and domain databases

InterProIPR002618. UDPGP_trans.
IPR016267. UDPGP_trans_subgr.
[Graphical view]
PANTHERPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFPIRSF000806. UDPGP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUGPA_PIG
AccessionPrimary (citable) accession number: P79303
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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