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P79303

- UGPA_PIG

UniProt

P79303 - UGPA_PIG

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi127 – 1271MagnesiumBy similarity
Metal bindingi253 – 2531MagnesiumBy similarity
Active sitei396 – 3961By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508UTP--glucose-1-phosphate uridylyltransferasePRO_0000185754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei438 – 4381N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP79303.
PRIDEiP79303.

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008931.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni457 – 50852OligomerizationBy similarityAdd
BLAST
Regioni502 – 5032Critical for end-to-end subunit interactionBy similarity

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000113618.
HOVERGENiHBG055396.
InParanoidiP79303.
KOiK00963.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

P79303-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTAPSHEFEH
60 70 80 90 100
TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN
110 120 130 140 150
ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN
160 170 180 190 200
KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES
210 220 230 240 250
LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS
260 270 280 290 300
NIDNLGATVD LYILNHLMNP PNGRPCEFVM EATNKARADV KGGTLTQYEG
310 320 330 340 350
KLRLVEIAQV PKPHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM
360 370 380 390 400
EIIVNPKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD
410 420 430 440 450
LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP
460 470 480 490 500
DMLELDHLTV SGDVTFGKNV SLKGTVIIIX NHGDRIDIPP GAVLENKIVS

GNLRILDH
Length:508
Mass (Da):56,953
Last modified:January 23, 2007 - v3
Checksum:i327F66CD91783965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99312 mRNA. Translation: CAA67690.1.
RefSeqiNP_999145.1. NM_213980.1.
UniGeneiSsc.5264.

Genome annotation databases

GeneIDi397040.
KEGGissc:397040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99312 mRNA. Translation: CAA67690.1 .
RefSeqi NP_999145.1. NM_213980.1.
UniGenei Ssc.5264.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000008931.

Proteomic databases

PaxDbi P79303.
PRIDEi P79303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397040.
KEGGi ssc:397040.

Organism-specific databases

CTDi 7360.

Phylogenomic databases

eggNOGi COG4284.
HOGENOMi HOG000113618.
HOVERGENi HBG055396.
InParanoidi P79303.
KOi K00963.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
PIRSFi PIRSF000806. UDPGP. 1 hit.
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "cDNA sequencing of the porcine UDP glucose pyrophosphorylase gene."
    Looft C., Paul S.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Muscle.

Entry informationi

Entry nameiUGPA_PIG
AccessioniPrimary (citable) accession number: P79303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3