Reviewed,
UniProtKB/Swiss-Prot P79290 (NOS2_PIG)
Last modified
November 25, 2008.
Version 57.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Nitric oxide synthase, inducible EC=1.14.13.39 Alternative name(s): Inducible NO synthase Short name=Inducible NOS Short name=iNOS NOS type II | ||
| Gene names |
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| Organism | Sus scrofa (Pig) | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 215 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. |
| Catalytic activity | L-arginine + n NADPH + m O(2) = citrulline + nitric oxide + n NADP(+). |
| Cofactor | Heme group By similarity. Binds 1 FAD By similarity. Binds 1 FMN By similarity. Metrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme By similarity. |
| Enzyme regulation | Not stimulated by calcium/calmodulin By similarity. |
| Subunit structure | Homodimer. Binds SLC9A3R1 By similarity. |
| Tissue specificity | Detected in both stimulated and unstimulated immune cells and macrophages with little or no up-regulation following cellular stimulation with lipopolysaccharides (LPS) or concanavalin A (ConA). |
| Induction | Little by LPS or ConA in spleen cells. |
| Sequence similarities | Belongs to the NOS family. |
Ontologies
Keywords | |
|---|---|
| Ligand | Calmodulin-binding FAD FMN Heme Iron Metal-binding NADP |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | nitric oxide biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW nitric-oxide synthase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Inducible nitric oxide synthase expression in porcine immune cells." Pampusch M.S., Bennaars A.M., Harsch S., Murtaugh M.P. Vet. Immunol. Immunopathol. 61:279-289(1998) [PubMed: 9613441] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Spleen. |
Cross-references
Sequence databases | |
|---|---|
| U59390 mRNA. Translation: AAB40614.1. | |
| UniGene | Ssc.16188 |
3D structure databases | |
| HSSP | HSSP built from PDB template 4NOS based on UniProtKB P35228. |
| SMR | P79290. Positions 1-215. |
| ModBase | Search... |
Phylogenomic databases | |
| HOVERGEN | P79290. |
Family and domain databases | |
| InterPro | IPR004030. NO_synthase_oxygenase_reg. [Graphical view] |
| Pfam | PF02898. NO_synthase. 1 hit. [Graphical view] |
| PROSITE | PS60001. NOS. Partial match. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NOS2_PIG | ||||||||
| Accession | Primary (citable) accession number: P79290 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


