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Protein

Pleiotrophin

Gene

PTN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Binds to cell-surface target proteins via their chondroitin sulfate groups. Down-regulates PTPRZ1 activity.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Pleiotrophin
Short name:
PTN
Alternative name(s):
Pleiotrophic factor beta
Short name:
PTF-beta
Gene namesi
Name:PTN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 18

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000023942633 – 168PleiotrophinAdd BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 76By similarity
Disulfide bondi55 ↔ 85By similarity
Disulfide bondi62 ↔ 89By similarity
Disulfide bondi99 ↔ 131By similarity
Disulfide bondi109 ↔ 141By similarity

Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP79281.
PRIDEiP79281.

Expressioni

Gene expression databases

BgeeiENSSSCG00000016522.
GenevisibleiP79281. SS.

Interactioni

Subunit structurei

Interacts with ALK and NEK6. Interacts with PTPRZ1 (probably via chondroitin sulfate groups).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017506.

Structurei

3D structure databases

ProteinModelPortaliP79281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni92 – 99Chondroitin sulfate bindingBy similarity8
Regioni123 – 131Chondroitin sulfate bindingBy similarity9
Regioni147 – 168Chondroitin sulfate A bindingBy similarityAdd BLAST22

Sequence similaritiesi

Belongs to the pleiotrophin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWNA. Eukaryota.
ENOG4111ZWP. LUCA.
GeneTreeiENSGT00390000007640.
HOGENOMiHOG000231473.
HOVERGENiHBG008317.
InParanoidiP79281.
KOiK16642.
OMAiGEDICNS.
OrthoDBiEOG091G0VCN.
TreeFamiTF332376.

Family and domain databases

Gene3Di2.20.60.10. 1 hit.
InterProiView protein in InterPro
IPR000762. Midkine_heparin-bd_GF.
IPR020090. PTN/MK_C_dom.
IPR020091. PTN/MK_diS.
IPR020089. PTN/MK_N_dom.
IPR020092. PTN_MK_heparin-bd_GF_CS.
PANTHERiPTHR13850. PTHR13850. 1 hit.
PfamiView protein in Pfam
PF01091. PTN_MK_C. 1 hit.
PF05196. PTN_MK_N. 1 hit.
PRINTSiPR00269. PTNMIDKINE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005592. PTN_MK_hepar_bd. 1 hit.
SMARTiView protein in SMART
SM00193. PTN. 1 hit.
SUPFAMiSSF57288. SSF57288. 2 hits.
PROSITEiView protein in PROSITE
PS00619. PTN_MK_1. 1 hit.
PS00620. PTN_MK_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTPQFLQQR RKFAAAFLAF IFLLAVVDTA EAGKKEKPEK KVKKSDCGEW
60 70 80 90 100
QWSVCVPTSG DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK
110 120 130 140 150
YQFQAWGECD LNTALKTRTG SLKRALHNAD CQKTVTISKP CGKVTKPKPQ
160
AESKKKKKEG KKQEKMLD
Length:168
Mass (Da):18,910
Last modified:May 1, 1997 - v1
Checksum:iBFA2A91DA2C6DCA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89546 mRNA. Translation: BAA13972.1.
RefSeqiNP_999501.1. NM_214336.1.
XP_013841040.1. XM_013985586.1.
UniGeneiSsc.12975.

Genome annotation databases

EnsembliENSSSCT00000017990; ENSSSCP00000017506; ENSSSCG00000016522.
GeneIDi397609.
KEGGissc:397609.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPTN_PIG
AccessioniPrimary (citable) accession number: P79281
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: May 1, 1997
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families