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Protein

Long-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene

ACADL

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Long-chain-acyl-CoA + electron-transfer flavoprotein = long-chain-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

Pathwayi: mitochondrial fatty acid beta-oxidation

This protein is involved in the pathway mitochondrial fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway mitochondrial fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-SSC-77285. Beta oxidation of myristoyl-CoA to lauroyl-CoA.
R-SSC-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.8)
Short name:
LCAD
Gene namesi
Name:ACADL
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 15

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 430400Long-chain specific acyl-CoA dehydrogenase, mitochondrialPRO_0000000512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421N6-acetyllysineBy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei55 – 551PhosphoserineBy similarity
Modified residuei66 – 661N6-acetyllysine; alternateBy similarity
Modified residuei66 – 661N6-succinyllysine; alternateBy similarity
Modified residuei81 – 811N6-acetyllysine; alternateBy similarity
Modified residuei81 – 811N6-succinyllysine; alternateBy similarity
Modified residuei92 – 921N6-acetyllysineBy similarity
Modified residuei95 – 951N6-acetyllysineBy similarity
Modified residuei165 – 1651N6-succinyllysineBy similarity
Modified residuei240 – 2401N6-succinyllysineBy similarity
Modified residuei254 – 2541N6-acetyllysine; alternateBy similarity
Modified residuei254 – 2541N6-succinyllysine; alternateBy similarity
Modified residuei279 – 2791N6-acetyllysine; alternateBy similarity
Modified residuei279 – 2791N6-succinyllysine; alternateBy similarity
Modified residuei318 – 3181N6-acetyllysineBy similarity
Modified residuei322 – 3221N6-acetyllysine; alternateBy similarity
Modified residuei322 – 3221N6-succinyllysine; alternateBy similarity
Modified residuei358 – 3581N6-acetyllysineBy similarity
Modified residuei362 – 3621PhosphoserineBy similarity

Post-translational modificationi

Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP79274.
PeptideAtlasiP79274.

Expressioni

Gene expression databases

GenevisibleiP79274. SS.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017114.

Structurei

3D structure databases

ProteinModelPortaliP79274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0141. Eukaryota.
ENOG410XNMY. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131659.
HOVERGENiHBG104903.
InParanoidiP79274.
KOiK00255.
OMAiKAGEAGM.
OrthoDBiEOG77126W.
TreeFamiTF105054.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRLLRGSL RLWGGLCAPR LPTASRCSHS GGEERLESPS AKKLTDIGIR
60 70 80 90 100
RIFSSEHDIF RESVRKFFQE EVIPHHAEWE KAGEVSRELW EKAGKQGLLG
110 120 130 140 150
INIAERHGGI GGDLYSAAIV WEEQAYSNCT GPGFSLHSDI VMPYIANYGS
160 170 180 190 200
EEQIKHFIPQ MTAGKCIGAI AMTEPGAGSD LQGVRTNAKK DGSDWILNGS
210 220 230 240 250
KVFITNGWLS DVVIVVAVTN REARSPAHGI SLFLVENGMK GFVKGRKLHK
260 270 280 290 300
IGLKAQDTAE LFFEDVRLPA SALLGEENKG FYYLMQELPQ ERLLIAELAV
310 320 330 340 350
SASEFMFEET RNYVKQRKAF GKTVAHIQTV QHKLAELKTH ICVTRAFVDS
360 370 380 390 400
CLQLHETKRL ESAAASMAKY WASELQNSVA YDCVQLHGGW GYMWEYPIAR
410 420 430
AYVDARVQPI YGGTNEIMKE LIAREIVHDK
Length:430
Mass (Da):47,957
Last modified:May 1, 1997 - v1
Checksum:i15772DA595AA6B16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89478 mRNA. Translation: BAA13965.1.
RefSeqiNP_999062.1. NM_213897.1.
UniGeneiSsc.14530.

Genome annotation databases

EnsembliENSSSCT00000017589; ENSSSCP00000017114; ENSSSCG00000016156.
GeneIDi396931.
KEGGissc:396931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89478 mRNA. Translation: BAA13965.1.
RefSeqiNP_999062.1. NM_213897.1.
UniGeneiSsc.14530.

3D structure databases

ProteinModelPortaliP79274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017114.

Proteomic databases

PaxDbiP79274.
PeptideAtlasiP79274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000017589; ENSSSCP00000017114; ENSSSCG00000016156.
GeneIDi396931.
KEGGissc:396931.

Organism-specific databases

CTDi33.

Phylogenomic databases

eggNOGiKOG0141. Eukaryota.
ENOG410XNMY. LUCA.
GeneTreeiENSGT00760000119007.
HOGENOMiHOG000131659.
HOVERGENiHBG104903.
InParanoidiP79274.
KOiK00255.
OMAiKAGEAGM.
OrthoDBiEOG77126W.
TreeFamiTF105054.

Enzyme and pathway databases

UniPathwayiUPA00660.
ReactomeiR-SSC-77285. Beta oxidation of myristoyl-CoA to lauroyl-CoA.
R-SSC-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.

Gene expression databases

GenevisibleiP79274. SS.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Suzuki H., Hamasima N., Kimura M., Yasue H.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiACADL_PIG
AccessioniPrimary (citable) accession number: P79274
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.