Reviewed, UniProtKB/Swiss-Prot P79274 (ACADL_PIG)

Names and origin

Protein names

Recommended name:
    Long-chain specific acyl-CoA dehydrogenase, mitochondrial
      Short name=LCAD
    EC=1.3.99.13

Gene names

Name:

ACADL

Organism

Sus scrofa (Pig)

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
Cofactor	FAD.
Pathway	Lipid metabolism; mitochondrial fatty acid beta-oxidation.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion matrix.
Miscellaneous	A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
Sequence similarities	Belongs to the acyl-CoA dehydrogenase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro long-chain-acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 30	30	Mitochondrion By similarity
	Chain	31 – 430	400	Long-chain specific acyl-CoA dehydrogenase, mitochondrial		PRO_0000000512

Sequences

	Sequence		Length	Mass (Da)
	P79274-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 15772DA595AA6B16	FASTA	430	47,957
	10 20 30 40 50 60 MATRLLRGSL RLWGGLCAPR LPTASRCSHS GGEERLESPS AKKLTDIGIR RIFSSEHDIF 70 80 90 100 110 120 RESVRKFFQE EVIPHHAEWE KAGEVSRELW EKAGKQGLLG INIAERHGGI GGDLYSAAIV 130 140 150 160 170 180 WEEQAYSNCT GPGFSLHSDI VMPYIANYGS EEQIKHFIPQ MTAGKCIGAI AMTEPGAGSD 190 200 210 220 230 240 LQGVRTNAKK DGSDWILNGS KVFITNGWLS DVVIVVAVTN REARSPAHGI SLFLVENGMK 250 260 270 280 290 300 GFVKGRKLHK IGLKAQDTAE LFFEDVRLPA SALLGEENKG FYYLMQELPQ ERLLIAELAV 310 320 330 340 350 360 SASEFMFEET RNYVKQRKAF GKTVAHIQTV QHKLAELKTH ICVTRAFVDS CLQLHETKRL 370 380 390 400 410 420 ESAAASMAKY WASELQNSVA YDCVQLHGGW GYMWEYPIAR AYVDARVQPI YGGTNEIMKE 430 LIAREIVHDK

References

[1]	Suzuki H., Hamasima N., Kimura M., Yasue H. Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D89478 mRNA. Translation: BAA13965.1.
RefSeq	NP_999062.1.
UniGene	Ssc.14530
3D structure databases
HSSP	HSSP built from PDB template 1IVH based on UniProtKB P26440.
ModBase	Search...
Genome annotation databases
GeneID	396931.
KEGG	ssc:396931.
Organism-specific databases
CTD	396931.
Phylogenomic databases
HOVERGEN	P79274.
Enzyme and pathway databases
BRENDA	1.3.99.13. 249.
Family and domain databases
InterPro	IPR006089. Acyl-CoA_DH_CS. IPR006092. Acyl-CoA_DH_N. IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
Pfam	PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. PF02771. Acyl-CoA_dh_N. 1 hit. [Graphical view]
PROSITE	PS00072. ACYL_COA_DH_1. 1 hit. PS00073. ACYL_COA_DH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACADL_PIG

Accession

Primary (citable) accession number: P79274

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	September 1, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)