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P79273

- ACADS_PIG

UniProt

P79273 - ACADS_PIG

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Protein

Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Gene
ACADS
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei161 – 1611Substrate; via carbonyl oxygen By similarity
Binding sitei297 – 2971FAD By similarity
Binding sitei297 – 2971FAD; shared with dimeric partner By similarity
Binding sitei308 – 3081FAD By similarity
Active sitei393 – 3931Proton acceptor By similarity
Binding sitei394 – 3941Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi152 – 16110FAD By similarity
Nucleotide bindingi185 – 1873FAD By similarity
Nucleotide bindingi366 – 3705FAD By similarity
Nucleotide bindingi366 – 3705FAD; shared with dimeric partner By similarity
Nucleotide bindingi395 – 3973FAD By similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. butyryl-CoA dehydrogenase activity Source: UniProtKB-EC
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.1)
Short name:
SCAD
Alternative name(s):
Butyryl-CoA dehydrogenase
Gene namesi
Name:ACADS
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion By similarityAdd
BLAST
Chaini25 – 413389Short-chain specific acyl-CoA dehydrogenase, mitochondrialPRO_0000000500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511N6-acetyllysine; alternate By similarity
Modified residuei51 – 511N6-succinyllysine; alternate By similarity
Modified residuei72 – 721N6-acetyllysine By similarity
Modified residuei129 – 1291N6-acetyllysine; alternate By similarity
Modified residuei129 – 1291N6-succinyllysine; alternate By similarity
Modified residuei208 – 2081N6-acetyllysine By similarity
Modified residuei262 – 2621N6-acetyllysine; alternate By similarity
Modified residuei262 – 2621N6-succinyllysine; alternate By similarity
Modified residuei306 – 3061N6-acetyllysine; alternate By similarity
Modified residuei306 – 3061N6-succinyllysine; alternate By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP79273.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010581.

Structurei

3D structure databases

ProteinModelPortaliP79273.
SMRiP79273. Positions 34-413.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2724Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000131659.
HOVERGENiHBG000224.
KOiK00248.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79273-1 [UniParc]FASTAAdd to Basket

« Hide

MAAALLARAC GPVRGALWPR DCRRLHTIFQ SVELPETYQM LRQTCRDFAE    50
KELVPIAAQV DKEHRFPEAQ VKKMGELGLM AMDVPEELSG AGLDYLAYTI 100
AMEEISRGCA STGVIMSVNN FLYLGPILKF GSKEQKQQWI TPFTSGDKVG 150
CFALSEPGNG SDAGAAATTA QADHDSWVLS GTKAWITNAW EASAAVVFAS 200
TDRSLQNKGI SAFLVPMPTA GLTLGKKEDK LGIRASSTAN LIFEDCRIPK 250
ENLLGEPGMG FKIAMKTLDM GRIGIASKAL GISQAALDCA VNYAENRRAF 300
GVPLTKLQGI QFKLADMALA LESARLLTWR AAMLKDNKKN PFIKEPAMAK 350
LAASEAATAI THQAIQILGG MGYVTEMPAE RHYRDARITE IYEGTSEIQR 400
LVIAGHLLKS YRS 413
Length:413
Mass (Da):44,851
Last modified:May 1, 1997 - v1
Checksum:iB8C480ADEFDF7E98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89477 mRNA. Translation: BAA13964.1.
RefSeqiNP_999063.1. NM_213898.1.
UniGeneiSsc.14531.

Genome annotation databases

GeneIDi396932.
KEGGissc:396932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89477 mRNA. Translation: BAA13964.1 .
RefSeqi NP_999063.1. NM_213898.1.
UniGenei Ssc.14531.

3D structure databases

ProteinModelPortali P79273.
SMRi P79273. Positions 34-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000010581.

Proteomic databases

PaxDbi P79273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396932.
KEGGi ssc:396932.

Organism-specific databases

CTDi 35.

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000131659.
HOVERGENi HBG000224.
KOi K00248.

Enzyme and pathway databases

UniPathwayi UPA00660 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of the pig short-chain acyl-CoA dehydrogenase gene and assignment to chromosome 14q16.2-q23.2."
    Suzuki H., Itoh T., Kimura M., Murakami Y., Hamasima N., Yasue H.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiACADS_PIG
AccessioniPrimary (citable) accession number: P79273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: March 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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