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Protein

Gastrin/cholecystokinin type B receptor

Gene

CCKBR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin/cholecystokinin type B receptor
Short name:
CCK-B receptor
Short name:
CCK-BR
Alternative name(s):
Cholecystokinin-2 receptor
Short name:
CCK2-R
Gene namesi
Name:CCKBR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757ExtracellularSequence analysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini80 – 878CytoplasmicSequence analysis
Transmembranei88 – 10922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini110 – 13122ExtracellularSequence analysisAdd
BLAST
Transmembranei132 – 15019Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini151 – 17020CytoplasmicSequence analysisAdd
BLAST
Transmembranei171 – 18919Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini190 – 21930ExtracellularSequence analysisAdd
BLAST
Transmembranei220 – 24223Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini243 – 34098CytoplasmicSequence analysisAdd
BLAST
Transmembranei341 – 36222Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini363 – 38018ExtracellularSequence analysisAdd
BLAST
Transmembranei381 – 40121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini402 – 45453CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 454454Gastrin/cholecystokinin type B receptorPRO_0000069472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation
Lipidationi415 – 4151S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP79266.
PRIDEiP79266.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006892.

Chemistry

BindingDBiP79266.

Structurei

3D structure databases

ProteinModelPortaliP79266.
SMRiP79266. Positions 359-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP79266.
KOiK04195.
OrthoDBiEOG7QVM36.
TreeFamiTF315303.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLKPNRSV LGSGPGPGAS LCRSGGPLLN GSGTGNLSCE PPRIRGAGTR
60 70 80 90 100
ELELAIRVTL YAVIFLMSVG GNVLIIVVLG LSRRLRTVTN AFLLSLAVSD
110 120 130 140 150
LLLAVACMPF TLLPNLMGTF IFGTVVCKAV SYFMGVSVSV STLSLVAIAL
160 170 180 190 200
ERYSAICRPL QARVWQTRSH AARVIVATWM LSGLLMVPYP VYTAVQPAGP
210 220 230 240 250
RVLQCMHRWP SARVRQTWSV LLLLLLFFVP GVVMAVAYGL ISRELYLGLR
260 270 280 290 300
FDGDSDSESQ SRVGSQGGLP GGTGQGPAQA NGRCRSETRL AGEDGDGCYV
310 320 330 340 350
QLPRSRPALE MSALTAPTPG PGSGTRPAQA KLLAKKRVVR MLLVIVVLFF
360 370 380 390 400
LCWLPVYSAN TWRAFDGPGA HRALSGAPIS FIHLLTYASA CVNPLVYCFM
410 420 430 440 450
HRRFRQACLD TCTRCCPRPP RARPRPLPDE DPPTPSIASL SRLSYTTIST

LGPG
Length:454
Mass (Da):48,781
Last modified:May 1, 1997 - v1
Checksum:iA2846A580508ABA6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861T → S in AAI12801 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83090 mRNA. Translation: AAB46896.1.
BC112800 mRNA. Translation: AAI12801.1.
RefSeqiNP_776687.2. NM_174262.3.
UniGeneiBt.582.

Genome annotation databases

GeneIDi281665.
KEGGibta:281665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83090 mRNA. Translation: AAB46896.1.
BC112800 mRNA. Translation: AAI12801.1.
RefSeqiNP_776687.2. NM_174262.3.
UniGeneiBt.582.

3D structure databases

ProteinModelPortaliP79266.
SMRiP79266. Positions 359-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006892.

Chemistry

BindingDBiP79266.
ChEMBLiCHEMBL2720.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP79266.
PRIDEiP79266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281665.
KEGGibta:281665.

Organism-specific databases

CTDi887.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiP79266.
KOiK04195.
OrthoDBiEOG7QVM36.
TreeFamiTF315303.

Miscellaneous databases

NextBioi20805596.

Family and domain databases

InterProiIPR009126. Cholcskin_rcpt.
IPR000314. Gastrin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00527. GASTRINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, developmental expression and pharmacological characterization of the CCKB/gastrin receptor in the calf pancreas."
    Dufresne M., Escrieut C., Clerc P., le Huerou-Luron I., Prats H., Bertrand V., le Meuth V., Guilloteau P., Vaysse N., Fourmy D.
    Eur. J. Pharmacol. 297:165-179(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiGASR_BOVIN
AccessioniPrimary (citable) accession number: P79266
Secondary accession number(s): Q2KI20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.