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Protein

S-arrestin

Gene

SAG

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
S-arrestin
Alternative name(s):
48 kDa protein
Retinal S-antigen
Short name:
S-AG
Rod photoreceptor arrestin
Gene namesi
Name:SAG
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Pathology & Biotechi

Involvement in diseasei

S-antigen induces autoimmune uveitis.

Keywords - Diseasei

Autoimmune uveitis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405S-arrestinPRO_0000205188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi131 ↔ 146Curated
Modified residuei233 – 2331PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP79260.
PeptideAtlasiP79260.

Expressioni

Tissue specificityi

Retina and pineal gland. Also expressed in the anterior tissues such as the ciliary epithelium and iris epithelium.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017271.

Structurei

3D structure databases

ProteinModelPortaliP79260.
SMRiP79260. Positions 12-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
HOVERGENiHBG002399.
InParanoidiP79260.
KOiK19627.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79260-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANVQASKS TPNHVIFKKT SRDKSVTIYL GKRDYIDHVD QVEPVDGVVL
60 70 80 90 100
VDPELVKGKR VYVSLTCAFR YGQEDIDVIG LSFRRDLYFS QVQVFPPVGA
110 120 130 140 150
ASQTKLQESL IKKLGGHTYP FLLTFPDYLP CSVMLQPAPQ DVGKCCGVDF
160 170 180 190 200
EVKAFATDSA DTGEDKIPKK SSVRLLIRKV QHAPLEMGPQ PHAEAAWQFF
210 220 230 240 250
MSDKPLHLTV SLSKELYYHG EPIPVTVTVT NNTEKTVKKI KALVEQVANV
260 270 280 290 300
VLYSSDYYIK PVATEETQQK VPPNSTLTTT LTLVPLLANN RERRGIADGK
310 320 330 340 350
IKHEDTNLAS STIIKEGMDK TIMGILVSYQ IKVQLTVSGL LGELTSSEVA
360 370 380 390 400
TEVPFRLMHP QPEDPEAMDS FQDENFVFEE FARQNLKDAG ELKEEKTDQE

AAAHE
Length:405
Mass (Da):45,103
Last modified:May 1, 1997 - v1
Checksum:iF9C0C8658CBFA73E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82664 mRNA. Translation: AAB46757.2.
RefSeqiNP_999244.1. NM_214079.1.
UniGeneiSsc.296.

Genome annotation databases

GeneIDi397151.
KEGGissc:397151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82664 mRNA. Translation: AAB46757.2.
RefSeqiNP_999244.1. NM_214079.1.
UniGeneiSsc.296.

3D structure databases

ProteinModelPortaliP79260.
SMRiP79260. Positions 12-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017271.

Proteomic databases

PaxDbiP79260.
PeptideAtlasiP79260.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397151.
KEGGissc:397151.

Organism-specific databases

CTDi6295.

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
HOVERGENiHBG002399.
InParanoidiP79260.
KOiK19627.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Porcine S-antigen: cDNA sequence and expression in retina, ciliary epithelium and iris."
    Singh A.K., Kumar G., Shinohara T., Shichi H.
    Exp. Eye Res. 62:299-308(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiARRS_PIG
AccessioniPrimary (citable) accession number: P79260
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: July 6, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Arrestin binds calcium.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.