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Protein

Interleukin-8

Gene

CXCL8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-375276. Peptide ligand-binding receptors.
R-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • intracellular Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 10179Interleukin-8PRO_0000005120Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 61By similarity
Disulfide bondi36 ↔ 77By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP79255.
PRIDEiP79255.

Expressioni

Gene expression databases

ExpressionAtlasiP79255. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026275.

Structurei

3D structure databases

ProteinModelPortaliP79255.
SMRiP79255. Positions 31-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP79255.
KOiK10030.
OMAiPRCANSE.
OrthoDBiEOG7GTT6P.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF15. PTHR10179:SF15. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKLAVALL AAFLLSAALC EAAVLSRMST ELRCQCIKTH STPFHPKFIK
60 70 80 90 100
ELRVIESGPH CENSEIIVKL TNGNEVCLNP KEKWVQKVVQ VFVKRAEKQD

P
Length:101
Mass (Da):11,291
Last modified:May 1, 1997 - v1
Checksum:i061A530507906736
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451H → Y in AAV97702 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82598 mRNA. Translation: AAB37483.1.
AF232704 mRNA. Translation: AAF37575.1.
AY849380 Genomic DNA. Translation: AAV97702.1.
EU276073 mRNA. Translation: ABX72071.1.
BC103310 mRNA. Translation: AAI03311.1.
RefSeqiNP_776350.1. NM_173925.2.
UniGeneiBt.49740.

Genome annotation databases

EnsembliENSBTAT00000026275; ENSBTAP00000026275; ENSBTAG00000019716.
GeneIDi280828.
KEGGibta:280828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82598 mRNA. Translation: AAB37483.1.
AF232704 mRNA. Translation: AAF37575.1.
AY849380 Genomic DNA. Translation: AAV97702.1.
EU276073 mRNA. Translation: ABX72071.1.
BC103310 mRNA. Translation: AAI03311.1.
RefSeqiNP_776350.1. NM_173925.2.
UniGeneiBt.49740.

3D structure databases

ProteinModelPortaliP79255.
SMRiP79255. Positions 31-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026275.

Proteomic databases

PaxDbiP79255.
PRIDEiP79255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026275; ENSBTAP00000026275; ENSBTAG00000019716.
GeneIDi280828.
KEGGibta:280828.

Organism-specific databases

CTDi3576.

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP79255.
KOiK10030.
OMAiPRCANSE.
OrthoDBiEOG7GTT6P.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-375276. Peptide ligand-binding receptors.
R-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Gene expression databases

ExpressionAtlasiP79255. baseline and differential.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF15. PTHR10179:SF15. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and sequencing of bovine interleukin 8 cDNA isolated from lipopolysaccharide stimulated monocytes in vitro."
    Galligan C.L., Yoshimura T., Coomber B.L.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Estimating probability of parentage in U.S. beef and dairy cattle with single nucleotide polymorphisms."
    Heaton M.P., Clawson M.L., Snelling W.M., Keele J.W., Harhay G.P., Wiedmann R.T., Bennett G.L., Smith T.P.L., Stone R.T., Freking B.A., Van Tassell C.P., Sonstegard T.S., Gasbarre L.C., Carr J., DiBello P., Kumar M., Lee M.S., Murthy J.
    , Otto J., Salisbury B., Schulz V., Tracy R., Hawk D.A., Kalbfleisch T., Laegreid W.W.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "U.S. veterinary immune reagent network: expressed bovine gene sequences."
    U.S. Veterinary Immune Reagent Network
    Hudgens T., Tompkins D., Baldwin C.L.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Belted Galloway.
    Tissue: Peripheral blood.
  5. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiIL8_BOVIN
AccessioniPrimary (citable) accession number: P79255
Secondary accession number(s): A9QWR1, Q3ZBG3, Q5MAD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.