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Protein

Interleukin-8

Gene

CXCL8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-375276. Peptide ligand-binding receptors.
R-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000512023 – 101Interleukin-8Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 61By similarity
Disulfide bondi36 ↔ 77By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP79255.
PRIDEiP79255.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019716.
ExpressionAtlasiP79255. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026275.

Structurei

3D structure databases

ProteinModelPortaliP79255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP79255.
KOiK10030.
OMAiPRCANSE.
OrthoDBiEOG091G13J8.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF15. PTHR10179:SF15. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKLAVALL AAFLLSAALC EAAVLSRMST ELRCQCIKTH STPFHPKFIK
60 70 80 90 100
ELRVIESGPH CENSEIIVKL TNGNEVCLNP KEKWVQKVVQ VFVKRAEKQD

P
Length:101
Mass (Da):11,291
Last modified:May 1, 1997 - v1
Checksum:i061A530507906736
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45H → Y in AAV97702 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82598 mRNA. Translation: AAB37483.1.
AF232704 mRNA. Translation: AAF37575.1.
AY849380 Genomic DNA. Translation: AAV97702.1.
EU276073 mRNA. Translation: ABX72071.1.
BC103310 mRNA. Translation: AAI03311.1.
RefSeqiNP_776350.1. NM_173925.2.
UniGeneiBt.49740.

Genome annotation databases

EnsembliENSBTAT00000026275; ENSBTAP00000026275; ENSBTAG00000019716.
GeneIDi280828.
KEGGibta:280828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82598 mRNA. Translation: AAB37483.1.
AF232704 mRNA. Translation: AAF37575.1.
AY849380 Genomic DNA. Translation: AAV97702.1.
EU276073 mRNA. Translation: ABX72071.1.
BC103310 mRNA. Translation: AAI03311.1.
RefSeqiNP_776350.1. NM_173925.2.
UniGeneiBt.49740.

3D structure databases

ProteinModelPortaliP79255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026275.

Proteomic databases

PaxDbiP79255.
PRIDEiP79255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026275; ENSBTAP00000026275; ENSBTAG00000019716.
GeneIDi280828.
KEGGibta:280828.

Organism-specific databases

CTDi3576.

Phylogenomic databases

eggNOGiENOG410J24U. Eukaryota.
ENOG410Z1BP. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP79255.
KOiK10030.
OMAiPRCANSE.
OrthoDBiEOG091G13J8.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-BTA-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-BTA-375276. Peptide ligand-binding receptors.
R-BTA-380108. Chemokine receptors bind chemokines.
R-BTA-418594. G alpha (i) signalling events.

Gene expression databases

BgeeiENSBTAG00000019716.
ExpressionAtlasiP79255. baseline and differential.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF15. PTHR10179:SF15. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL8_BOVIN
AccessioniPrimary (citable) accession number: P79255
Secondary accession number(s): A9QWR1, Q3ZBG3, Q5MAD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.