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Protein

5-hydroxytryptamine receptor 1B

Gene

HTR1B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).By similarity

Miscellaneous

A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354Important for species-specific agonist sensitivityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBehavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1B
Short name:
5-HT-1B
Short name:
5-HT1B
Short name:
5-HTR1B
Alternative name(s):
5-HT1D subtype beta
Serotonin receptor 1B
Gene namesi
Name:HTR1B
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularBy similarityAdd BLAST48
Transmembranei49 – 74Helical; Name=1By similarityAdd BLAST26
Topological domaini75 – 83CytoplasmicBy similarity9
Transmembranei84 – 109Helical; Name=2By similarityAdd BLAST26
Topological domaini110 – 122ExtracellularBy similarityAdd BLAST13
Transmembranei123 – 144Helical; Name=3By similarityAdd BLAST22
Topological domaini145 – 164CytoplasmicBy similarityAdd BLAST20
Transmembranei165 – 186Helical; Name=4By similarityAdd BLAST22
Topological domaini187 – 204ExtracellularBy similarityAdd BLAST18
Transmembranei205 – 227Helical; Name=5By similarityAdd BLAST23
Topological domaini228 – 314CytoplasmicBy similarityAdd BLAST87
Transmembranei315 – 335Helical; Name=6By similarityAdd BLAST21
Topological domaini336 – 348ExtracellularBy similarityAdd BLAST13
Transmembranei349 – 370Helical; Name=7By similarityAdd BLAST22
Topological domaini371 – 389CytoplasmicBy similarityAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689101 – 3895-hydroxytryptamine receptor 1BAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Lipidationi387S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

Phosphorylated.By similarity
Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1D (By similarity).By similarity

Chemistry databases

BindingDBiP79250

Structurei

3D structure databases

ProteinModelPortaliP79250
SMRiP79250
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 133Agonist bindingBy similarity10
Regioni326 – 330Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi145 – 147DRY motif; important for ligand-induced conformation changes and signalingBy similarity3
Motifi364 – 368NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Domaini

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962
InParanoidiP79250
KOiK04153

Family and domain databases

InterProiView protein in InterPro
IPR002147 5HT1B_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF16 PTHR24247:SF16, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00513 5HT1BRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P79250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAGAPCAP PPPAGSQTGA PPANLSSAPH NCSAEGYIYQ DSVALPWKVL
60 70 80 90 100
LVILLALITL ATTLSNAFVI ATVYRTRKLH TPANYLIASL AVTDLLVSIL
110 120 130 140 150
VMPISTMYTV TGRWTLGQVV CDLWLSSDIT CCTASILHLC VIALDRYWAI
160 170 180 190 200
TDAVEYSAKR TPKRAAVMIA LVWVFSISIS LPPFFWRQAK AEEEVSDCVV
210 220 230 240 250
NTDHILYTVY STVGAFYFPT LLLIALYGRI YVEARSRILK QTPNRTGKRL
260 270 280 290 300
TRAQLITDSP GSTSSVTSVN SRAPDVPSES GSPVYVNQVK VRVSDALLEK
310 320 330 340 350
KKLMAARERK ATKTLGIILG AFIVCWLPFF IISLVMPICK DACWFHLAIF
360 370 380
DFFTWLGYLN SLINPIIYTM SNEDFKQAFH KLIRFKCAG
Length:389
Mass (Da):42,930
Last modified:April 12, 2005 - v2
Checksum:i4CCB4CCB5792936D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323909 Genomic DNA Translation: AAQ89935.1
AB193090 mRNA Translation: BAD60920.1
AY204572 Genomic DNA Translation: AAP12469.1
S82461 mRNA Translation: AAB37488.2
RefSeqiNP_001006949.1, NM_001006948.1
UniGeneiCfa.3604

Genome annotation databases

GeneIDi403741
KEGGicfa:403741

Similar proteinsi

Entry informationi

Entry namei5HT1B_CANLF
AccessioniPrimary (citable) accession number: P79250
Secondary accession number(s): Q6VVV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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