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Protein

5-hydroxytryptamine receptor 1B

Gene

HTR1B

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei354Important for species-specific agonist sensitivityBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1B
Short name:
5-HT-1B
Short name:
5-HT1B
Short name:
5-HTR1B
Alternative name(s):
5-HT1D subtype beta
Serotonin receptor 1B
Gene namesi
Name:HTR1B
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularBy similarityAdd BLAST48
Transmembranei49 – 74Helical; Name=1By similarityAdd BLAST26
Topological domaini75 – 83CytoplasmicBy similarity9
Transmembranei84 – 109Helical; Name=2By similarityAdd BLAST26
Topological domaini110 – 122ExtracellularBy similarityAdd BLAST13
Transmembranei123 – 144Helical; Name=3By similarityAdd BLAST22
Topological domaini145 – 164CytoplasmicBy similarityAdd BLAST20
Transmembranei165 – 186Helical; Name=4By similarityAdd BLAST22
Topological domaini187 – 204ExtracellularBy similarityAdd BLAST18
Transmembranei205 – 227Helical; Name=5By similarityAdd BLAST23
Topological domaini228 – 314CytoplasmicBy similarityAdd BLAST87
Transmembranei315 – 335Helical; Name=6By similarityAdd BLAST21
Topological domaini336 – 348ExtracellularBy similarityAdd BLAST13
Transmembranei349 – 370Helical; Name=7By similarityAdd BLAST22
Topological domaini371 – 389CytoplasmicBy similarityAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689101 – 3895-hydroxytryptamine receptor 1BAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 198PROSITE-ProRule annotation
Lipidationi387S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

Phosphorylated.By similarity
Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Interactioni

Subunit structurei

Homodimer. Heterodimer with HTR1D (By similarity).By similarity

Chemistry databases

BindingDBiP79250.

Structurei

3D structure databases

ProteinModelPortaliP79250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 133Agonist bindingBy similarity10
Regioni326 – 330Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi145 – 147DRY motif; important for ligand-induced conformation changes and signalingBy similarity3
Motifi364 – 368NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Domaini

Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiP79250.
KOiK04153.

Family and domain databases

InterProiIPR002147. 5HT1B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF16. PTHR24247:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00513. 5HT1BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79250-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAAGAPCAP PPPAGSQTGA PPANLSSAPH NCSAEGYIYQ DSVALPWKVL
60 70 80 90 100
LVILLALITL ATTLSNAFVI ATVYRTRKLH TPANYLIASL AVTDLLVSIL
110 120 130 140 150
VMPISTMYTV TGRWTLGQVV CDLWLSSDIT CCTASILHLC VIALDRYWAI
160 170 180 190 200
TDAVEYSAKR TPKRAAVMIA LVWVFSISIS LPPFFWRQAK AEEEVSDCVV
210 220 230 240 250
NTDHILYTVY STVGAFYFPT LLLIALYGRI YVEARSRILK QTPNRTGKRL
260 270 280 290 300
TRAQLITDSP GSTSSVTSVN SRAPDVPSES GSPVYVNQVK VRVSDALLEK
310 320 330 340 350
KKLMAARERK ATKTLGIILG AFIVCWLPFF IISLVMPICK DACWFHLAIF
360 370 380
DFFTWLGYLN SLINPIIYTM SNEDFKQAFH KLIRFKCAG
Length:389
Mass (Da):42,930
Last modified:April 12, 2005 - v2
Checksum:i4CCB4CCB5792936D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323909 Genomic DNA. Translation: AAQ89935.1.
AB193090 mRNA. Translation: BAD60920.1.
AY204572 Genomic DNA. Translation: AAP12469.1.
S82461 mRNA. Translation: AAB37488.2.
RefSeqiNP_001006949.1. NM_001006948.1.
UniGeneiCfa.3604.

Genome annotation databases

GeneIDi403741.
KEGGicfa:403741.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323909 Genomic DNA. Translation: AAQ89935.1.
AB193090 mRNA. Translation: BAD60920.1.
AY204572 Genomic DNA. Translation: AAP12469.1.
S82461 mRNA. Translation: AAB37488.2.
RefSeqiNP_001006949.1. NM_001006948.1.
UniGeneiCfa.3604.

3D structure databases

ProteinModelPortaliP79250.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP79250.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403741.
KEGGicfa:403741.

Organism-specific databases

CTDi3351.

Phylogenomic databases

HOVERGENiHBG106962.
InParanoidiP79250.
KOiK04153.

Family and domain databases

InterProiIPR002147. 5HT1B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF16. PTHR24247:SF16. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00513. 5HT1BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT1B_CANLF
AccessioniPrimary (citable) accession number: P79250
Secondary accession number(s): Q6VVV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: April 12, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A residue in the 7th transmembrane region ('Thr-355' in human, 'Asn-351' in mouse and rat) is important for species-specific sensitivity to various agonists.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.