ID   LEG10_PONPY             Reviewed;          68 AA.
AC   P79238;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Galectin-10;
DE            Short=Gal-10;
DE   AltName: Full=Charcot-Leyden crystal protein homolog;
DE            Short=CLC;
DE   Flags: Fragment;
GN   Name=CLC;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9119387; DOI=10.1006/geno.1996.4590;
RA   Dyer K.D., Handen J.S., Rosenberg H.F.;
RT   "The genomic structure of the human Charcot-Leyden crystal protein gene is
RT   analogous to those of the galectin genes.";
RL   Genomics 40:217-221(1997).
CC   -!- FUNCTION: Regulates immune responses through the recognition of cell-
CC       surface glycans. Essential for the anergy and suppressive function of
CC       CD25-positive regulatory T-cells (Treg) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CEL. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic
CC       granule {ECO:0000250}. Note=Localized in granules from where it may be
CC       secreted or transported to other locations in the cell. {ECO:0000250}.
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DR   EMBL; U67984; AAB41695.1; -; Genomic_DNA.
DR   AlphaFoldDB; P79238; -.
DR   SMR; P79238; -.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR   GO; GO:0046006; P:regulation of activated T cell proliferation; ISS:UniProtKB.
DR   GO; GO:0002667; P:regulation of T cell anergy; ISS:UniProtKB.
DR   GO; GO:0002724; P:regulation of T cell cytokine production; ISS:UniProtKB.
DR   GO; GO:0070231; P:T cell apoptotic process; ISS:UniProtKB.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR044156; Galectin-like.
DR   InterPro; IPR001079; Galectin_CRD.
DR   PANTHER; PTHR11346; GALECTIN; 1.
DR   PANTHER; PTHR11346:SF15; GALECTIN-10-RELATED; 1.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lectin.
FT   CHAIN           <1..>68
FT                   /note="Galectin-10"
FT                   /id="PRO_0000076962"
FT   DOMAIN          <1..>68
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   NON_TER         1
FT   NON_TER         68
SQ   SEQUENCE   68 AA;  8006 MW;  A3B10878EED127B8 CRC64;
     EPYLQVDFHT EMKEESGIAF HFQVHFGCYV VMNSREYGAW KKPVESKNMP FQDGQEFDLS
     ISVLPDKY
//