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Protein

Galectin-10

Gene

CLC

Organism
Pongo pygmaeus (Bornean orangutan)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-10
Short name:
Gal-10
Alternative name(s):
Charcot-Leyden crystal protein homolog
Short name:
CLC
Gene namesi
Name:CLC
OrganismiPongo pygmaeus (Bornean orangutan)
Taxonomic identifieri9600 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000076962‹1 – ›68Galectin-10Add BLAST›68

Interactioni

Subunit structurei

Interacts with CEL.By similarity

Structurei

3D structure databases

ProteinModelPortaliP79238.
SMRiP79238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – ›68GalectinPROSITE-ProRule annotationAdd BLAST›68

Phylogenomic databases

HOGENOMiHOG000015090.

Family and domain databases

InterProiView protein in InterPro
IPR013320. ConA-like_dom_sf.
IPR030648. Galectin_10.
IPR001079. Galectin_CRD.
PANTHERiPTHR11346:SF15. PTHR11346:SF15. 1 hit.
PfamiView protein in Pfam
PF00337. Gal-bind_lectin. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS51304. GALECTIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

P79238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EPYLQVDFHT EMKEESGIAF HFQVHFGCYV VMNSREYGAW KKPVESKNMP
60
FQDGQEFDLS ISVLPDKY
Length:68
Mass (Da):8,006
Last modified:May 1, 1997 - v1
Checksum:iA3B10878EED127B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei681

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U67984 Genomic DNA. Translation: AAB41695.1.

Similar proteinsi

Entry informationi

Entry nameiLEG10_PONPY
AccessioniPrimary (citable) accession number: P79238
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 22, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program