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P79238 (LEG10_PONPY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galectin-10

Short name=Gal-10
Alternative name(s):
Charcot-Leyden crystal protein homolog
Short name=CLC
Gene names
Name:CLC
OrganismPongo pygmaeus (Bornean orangutan)
Taxonomic identifier9600 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Protein attributes

Sequence length68 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) By similarity.

Subunit structure

Interacts with CEL By similarity.

Subcellular location

Cytoplasmcytosol By similarity. Cytoplasmic granule By similarity. Note: Localized in granules from where it may be secreted or transported to other locations in the cell By similarity.

Sequence similarities

Contains 1 galectin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›68›68Galectin-10
PRO_0000076962

Regions

Domain‹1 – ›68›68Galectin

Experimental info

Non-terminal residue11
Non-terminal residue681

Sequences

Sequence LengthMass (Da)Tools
P79238 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A3B10878EED127B8

FASTA688,006
        10         20         30         40         50         60 
EPYLQVDFHT EMKEESGIAF HFQVHFGCYV VMNSREYGAW KKPVESKNMP FQDGQEFDLS 


ISVLPDKY 

« Hide

References

[1]"The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes."
Dyer K.D., Handen J.S., Rosenberg H.F.
Genomics 40:217-221(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U67984 Genomic DNA. Translation: AAB41695.1.

3D structure databases

ProteinModelPortalP79238.
SMRP79238. Positions 1-68.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG307598.
HOGENOMHOG000015090.
InParanoidP79238.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS51304. GALECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLEG10_PONPY
AccessionPrimary (citable) accession number: P79238
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 13, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families