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P79238

- LEG10_PONPY

UniProt

P79238 - LEG10_PONPY

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Protein
Galectin-10
Gene
CLC
Organism
Pongo pygmaeus (Bornean orangutan)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg) By similarity.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB

GO - Biological processi

  1. T cell apoptotic process Source: UniProtKB
  2. regulation of T cell anergy Source: UniProtKB
  3. regulation of T cell cytokine production Source: UniProtKB
  4. regulation of activated T cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-10
Short name:
Gal-10
Alternative name(s):
Charcot-Leyden crystal protein homolog
Short name:
CLC
Gene namesi
Name:CLC
OrganismiPongo pygmaeus (Bornean orangutan)
Taxonomic identifieri9600 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Subcellular locationi

Cytoplasmcytosol By similarity. Cytoplasmic granule By similarity
Note: Localized in granules from where it may be secreted or transported to other locations in the cell By similarity.

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›68›68Galectin-10
PRO_0000076962Add
BLAST

Interactioni

Subunit structurei

Interacts with CEL By similarity.

Structurei

3D structure databases

ProteinModelPortaliP79238.
SMRiP79238. Positions 1-68.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – ›68›68Galectin
Add
BLAST

Sequence similaritiesi

Contains 1 galectin domain.

Phylogenomic databases

eggNOGiNOG307598.
HOGENOMiHOG000015090.
InParanoidiP79238.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51304. GALECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P79238-1 [UniParc]FASTAAdd to Basket

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EPYLQVDFHT EMKEESGIAF HFQVHFGCYV VMNSREYGAW KKPVESKNMP   50
FQDGQEFDLS ISVLPDKY 68
Length:68
Mass (Da):8,006
Last modified:May 1, 1997 - v1
Checksum:iA3B10878EED127B8
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei68 – 681

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67984 Genomic DNA. Translation: AAB41695.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U67984 Genomic DNA. Translation: AAB41695.1 .

3D structure databases

ProteinModelPortali P79238.
SMRi P79238. Positions 1-68.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG307598.
HOGENOMi HOG000015090.
InParanoidi P79238.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view ]
Pfami PF00337. Gal-bind_lectin. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51304. GALECTIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genomic structure of the human Charcot-Leyden crystal protein gene is analogous to those of the galectin genes."
    Dyer K.D., Handen J.S., Rosenberg H.F.
    Genomics 40:217-221(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLEG10_PONPY
AccessioniPrimary (citable) accession number: P79238
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: November 13, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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