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P79202

- CP11A_SHEEP

UniProt

P79202 - CP11A_SHEEP

Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

CYP11A1

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

    Catalytic activityi

    Cholesterol + 6 reduced adrenodoxin + 3 O2 = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.

    Cofactori

    Heme group.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi461 – 4611Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. cholesterol monooxygenase (side-chain-cleaving) activity Source: UniProtKB
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. C21-steroid hormone biosynthetic process Source: UniProtKB
    2. cholesterol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Steroidogenesis, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00229.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholesterol side-chain cleavage enzyme, mitochondrial (EC:1.14.15.6)
    Alternative name(s):
    CYPXIA1
    Cholesterol desmolase
    Cytochrome P450 11A1
    Cytochrome P450(scc)
    Gene namesi
    Name:CYP11A1
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3939Mitochondrion1 PublicationAdd
    BLAST
    Chaini40 – 520481Cholesterol side-chain cleavage enzyme, mitochondrialPRO_0000003591Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with FDX1/adrenodoxin.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP79202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG051098.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P79202-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLARGLPFRS ALVKACPPLL NTGREGWGHH RVGTGEGAGI STRTPRPYSE    50
    IPSPGDNGWI NLYHFWRKKG SQRIHFHHIE NFQKYGPIYR EKLGNLESVY 100
    IIHPEGVAHL FKFEGSYPQR YDIPPWLAYH RYYQKPIGVL FKKSGAWKKD 150
    RVVLNTEVMA PEAIKNFIPL LNPVSQDFVS LLHKRIKQQG SGKFVGDIKE 200
    DLFRFAFESI TNVMFGERLG MLEDTVDTEA QKFIDAVYKM FHTSVPLLNL 250
    PPELYRLFRT KTWRDHVAAW DTIFNKAEKY TEIFYQDLRQ KTEFRNYPGI 300
    LYHLLKSEKM LLEDVKANIT EMLAGGVDTT SMTLQWHLYE MARSLNVQEM 350
    LRKEVLNARR QAEGDISKML QMVPLLKASI KETLRLHPIS VTLQRYPESD 400
    LVLQDYLIPA KTLVQVAIYA MGRDPAFFSN PDKFDPTRWL GKDKDLIHFR 450
    NLGFGWGVRQ CVGRRIAELE MTLFLIHILE NFRVEMQQIG DVNTIFNLIL 500
    TPDKPIFLVF RPFNQGPPQA 520
    Length:520
    Mass (Da):60,357
    Last modified:May 1, 1997 - v1
    Checksum:iDF8989FB8A87E8AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50057 mRNA. Translation: BAA08775.1.
    RefSeqiNP_001087258.1. NM_001093789.1.
    UniGeneiOar.5829.

    Genome annotation databases

    GeneIDi100048994.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50057 mRNA. Translation: BAA08775.1 .
    RefSeqi NP_001087258.1. NM_001093789.1.
    UniGenei Oar.5829.

    3D structure databases

    ProteinModelPortali P79202.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100048994.

    Organism-specific databases

    CTDi 1583.

    Phylogenomic databases

    HOVERGENi HBG051098.

    Enzyme and pathway databases

    UniPathwayi UPA00229 .

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and nucleotide sequences of cDNA clones of sheep and goat adrenocortical cytochromes P450scc (CYP11A1)."
      Okuyama E., Okazaki T., Furukawa A., Wu R.-F., Ichikawa Y.
      J. Steroid Biochem. Mol. Biol. 57:179-185(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adrenal cortex.
    2. "Purification and comparative characterization of cytochrome P-450scc (CYP XIA1) from sheep adrenocortical mitochondria."
      Miyatake A., Tsubaki M., Hori H., Ichikawa Y.
      Biochim. Biophys. Acta 1215:176-182(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 40-62.
      Tissue: Adrenal cortex.

    Entry informationi

    Entry nameiCP11A_SHEEP
    AccessioniPrimary (citable) accession number: P79202
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3