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P79152 (CP3AJ_CAPAE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A19

EC=1.14.14.1
Alternative name(s):
CYPIIIA19
Gene names
Name:CYP3A19
OrganismCapra aegagrus (Wild goat)
Taxonomic identifier9923 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Protein attributes

Sequence length218 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 218›218Cytochrome P450 3A19
PRO_0000051802

Sites

Metal binding1531Iron (heme axial ligand) By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P79152 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 24D22DA1CAF2DC00

FASTA21824,852
        10         20         30         40         50         60 
RHEVELVAQT TIFIFGGYET TSTSLSFIIY ELATHPDVQQ KLQEEIDATF PNKAPPTYDA 

        70         80         90        100        110        120 
LVQMEYLDMV VNETLRMFPI AGRLERLCKK DVEIHGVSIP KGTTVMVPLF VLHNNPEFWP 

       130        140        150        160        170        180 
EPEEFRPERF SKKNKDGINP YVYLPFGTGP RNCVGMRFAL MNIKLALVRI LQNFSFIPCK 

       190        200        210 
ETQIPLKLYT QGLTQPEQPV ILKVAPRGLG PQAEPDFL 

« Hide

References

[1]Zeilmaker W.M., van 't Klooster G.A.E., Gremmels-Gehrmann J.F., van Miert A.S.J.P.A., Horbach G.J.M.J.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: West-African dwarf.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76503 mRNA. Translation: CAA54038.1.

3D structure databases

ProteinModelPortalP79152.
SMRP79152. Positions 3-207.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG108567.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AJ_CAPAE
AccessionPrimary (citable) accession number: P79152
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: December 11, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families