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Protein

Fibroblast growth factor 7

Gene

FGF7

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-CFA-109704. PI3K Cascade.
R-CFA-1257604. PIP3 activates AKT signaling.
R-CFA-190377. FGFR2b ligand binding and activation.
R-CFA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-CFA-5654695. PI-3K cascade:FGFR2.
R-CFA-5654699. SHC-mediated cascade:FGFR2.
R-CFA-5654700. FRS-mediated FGFR2 signaling.
R-CFA-5654727. Negative regulation of FGFR2 signaling.
R-CFA-5673001. RAF/MAP kinase cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 7
Short name:
FGF-7
Alternative name(s):
Heparin-binding growth factor 7
Short name:
HBGF-7
Keratinocyte growth factor
Gene namesi
Name:FGF7
Synonyms:KGF
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 30

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131By similarityAdd
BLAST
Chaini32 – 194163Fibroblast growth factor 7PRO_0000008963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP79150.

Interactioni

Subunit structurei

Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000021986.

Structurei

3D structure databases

ProteinModelPortaliP79150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP79150.
KOiK04358.
OMAiNCSKHER.
OrthoDBiEOG7992S1.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79150-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE
60 70 80 90 100
RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI
110 120 130 140 150
RTVAVGIVAI KGVESEYYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT
160 170 180 190
YASAKWTHSG GEMFVALNQK GVPVRGKKTK KEQKTAHFLP MAIT
Length:194
Mass (Da):22,476
Last modified:May 1, 1997 - v1
Checksum:i8B4E56304B8F14D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80800 mRNA. Translation: AAB38972.1.
RefSeqiNP_001003237.1. NM_001003237.1.
XP_005638232.1. XM_005638175.2.
UniGeneiCfa.3776.

Genome annotation databases

EnsembliENSCAFT00000023682; ENSCAFP00000021986; ENSCAFG00000014923.
GeneIDi403915.
KEGGicfa:403915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U80800 mRNA. Translation: AAB38972.1.
RefSeqiNP_001003237.1. NM_001003237.1.
XP_005638232.1. XM_005638175.2.
UniGeneiCfa.3776.

3D structure databases

ProteinModelPortaliP79150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000021986.

Proteomic databases

PaxDbiP79150.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000023682; ENSCAFP00000021986; ENSCAFG00000014923.
GeneIDi403915.
KEGGicfa:403915.

Organism-specific databases

CTDi2252.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP79150.
KOiK04358.
OMAiNCSKHER.
OrthoDBiEOG7992S1.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-CFA-109704. PI3K Cascade.
R-CFA-1257604. PIP3 activates AKT signaling.
R-CFA-190377. FGFR2b ligand binding and activation.
R-CFA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-CFA-5654695. PI-3K cascade:FGFR2.
R-CFA-5654699. SHC-mediated cascade:FGFR2.
R-CFA-5654700. FRS-mediated FGFR2 signaling.
R-CFA-5654727. Negative regulation of FGFR2 signaling.
R-CFA-5673001. RAF/MAP kinase cascade.

Miscellaneous databases

NextBioi20817407.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028247. FGF7.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF20. PTHR11486:SF20. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Keratinocyte growth factor (KGF/FGF-7) has a paracrine role in canine prostate: molecular cloning of mRNA encoding canine KGF."
    Canatan H., Chang W.Y., Sugimoto Y., Shidaifat F., Kulp S.K., Brueggemeier R.W., Lin Y.C.
    DNA Cell Biol. 15:247-254(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFGF7_CANLF
AccessioniPrimary (citable) accession number: P79150
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1997
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.