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P79148 (ADRB1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-1 adrenergic receptor
Alternative name(s):
Beta-1 adrenoreceptor
Short name=Beta-1 adrenoceptor
Gene names
Name:ADRB1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis ›

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

Subunit structure

Interacts with GOPC, MAGI3 and DLG4 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression By similarity.

Domain

The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor By similarity.

Post-translational modification

Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Beta-1 adrenergic receptor
PRO_0000069116

Regions

Topological domain1 – 5555Extracellular By similarity
Transmembrane56 – 8429Helical; Name=1; By similarity
Topological domain85 – 939Cytoplasmic By similarity
Transmembrane94 – 12027Helical; Name=2; By similarity
Topological domain121 – 13212Extracellular By similarity
Transmembrane133 – 15422Helical; Name=3; By similarity
Topological domain155 – 17218Cytoplasmic By similarity
Transmembrane173 – 19624Helical; Name=4; By similarity
Topological domain197 – 22226Extracellular By similarity
Transmembrane223 – 24826Helical; Name=5; By similarity
Topological domain249 – 31668Cytoplasmic By similarity
Transmembrane317 – 34630Helical; Name=6; By similarity
Topological domain347 – 3515Extracellular By similarity
Transmembrane352 – 37423Helical; Name=7; By similarity
Topological domain375 – 47399Cytoplasmic By similarity
Region218 – 23215Agonist and antagonist binding By similarity
Region334 – 3418Agonist and antagonist binding By similarity
Region360 – 3645Agonist and antagonist binding By similarity
Motif470 – 4734PDZ-Binding By similarity

Sites

Binding site1381Agonist or antagonist By similarity
Binding site1431Agonist or antagonist By similarity

Amino acid modifications

Modified residue3091Phosphoserine; by PKA Potential
Lipidation3891S-palmitoyl cysteine By similarity
Glycosylation151N-linked (GlcNAc...) Probable
Disulfide bond131 ↔ 216 By similarity
Disulfide bond209 ↔ 215 By similarity

Sequences

Sequence LengthMass (Da)Tools
P79148 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 361357F7DF9DBD7E

FASTA47350,061
        10         20         30         40         50         60 
MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVPASPSA SPLAPTSEGP APLSQQWTAG 

        70         80         90        100        110        120 
IGLLMALIVL LIVAGNVLVI AAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVM 

       130        140        150        160        170        180 
RGRWEYGSFL CELWTSVDVL CVTASIETLC VIALDRYLAI TAPFRYQSLL TRARARALVC 

       190        200        210        220        230        240 
TVWAISALVS FLPILMHWWR AGGDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM 

       250        260        270        280        290        300 
AFVYLRVFRE AQKQVKKIDS CERRFLGGPA RPPAPPPAPA PAPPPAPGSP RPAAAAPLAN 

       310        320        330        340        350        360 
GRVGRRRPSR LVALREQKAL KTLGIIMGVF TLCWLPFFLA NVVKAFHRDL VPDRLFVFFN 

       370        380        390        400        410        420 
WLGYANSAFN PIIYCRSPDF RRAFQRLLCC ARRAARGSHG AAGDPPRARP PPSPGAASDD 

       430        440        450        460        470 
DDDDEDDAGA GAGAAPPARL LEPWAGCNGG AAADSDSSLD GAGSPAGASE SRV

« Hide

References

[1]"Molecular cloning of the dog beta 1 and beta 2 adrenergic receptors."
Huang R.-R.C., Rapoport D., Schaeffer M.-T., Cascieri M.A., Fong T.M.
J. Recept. Signal Transduct. 17:599-607(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U73207 Genomic DNA. Translation: AAB93648.1.
RefSeqNP_001008713.1. NM_001008713.1.
UniGeneCfa.23465.

3D structure databases

ProteinModelPortalP79148.
SMRP79148. Positions 56-388.
ModBaseSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000035025.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493972.
KEGGcfa:493972.

Organism-specific databases

CTD153.

Phylogenomic databases

eggNOGNOG262978.
HOGENOMHOG000239242.
HOVERGENHBG106962.
KOK04141.
OrthoDBEOG4WQ12W.

Family and domain databases

InterProIPR000507. Adrgc_rcpt_B1.
IPR002233. Adrnrgc_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20865510.

Entry information

Entry nameADRB1_CANFA
AccessionPrimary (citable) accession number: P79148
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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