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P79134

- ANXA6_BOVIN

UniProt

P79134 - ANXA6_BOVIN

Protein

Annexin A6

Gene

ANXA6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

    GO - Molecular functioni

    1. actin filament binding Source: AgBase
    2. calcium channel activity Source: AgBase
    3. calcium-dependent phospholipid binding Source: AgBase
    4. calcium-dependent protein binding Source: AgBase
    5. calcium ion binding Source: InterPro
    6. chondroitin sulfate binding Source: AgBase
    7. enzyme binding Source: AgBase
    8. heparin binding Source: AgBase
    9. identical protein binding Source: AgBase
    10. receptor activity Source: AgBase

    GO - Biological processi

    1. biomineral tissue development Source: AgBase
    2. calcium ion import Source: AgBase
    3. calcium ion transmembrane transport Source: GOC
    4. calcium ion transport Source: AgBase
    5. growth plate cartilage chondrocyte differentiation Source: AgBase
    6. regulation of muscle contraction Source: AgBase

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A6
    Alternative name(s):
    Annexin VI
    Annexin-6
    Gene namesi
    Name:ANXA6
    Synonyms:ANX6
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    Cytoplasm By similarity. Melanosome By similarity

    GO - Cellular componenti

    1. chromaffin granule membrane Source: AgBase
    2. cytoplasm Source: AgBase
    3. extracellular vesicular exosome Source: Ensembl
    4. focal adhesion Source: AgBase
    5. integral component of membrane Source: AgBase
    6. melanosome Source: UniProtKB-SubCell
    7. membrane Source: AgBase
    8. membrane-bounded vesicle Source: AgBase
    9. mitochondrial crista Source: AgBase
    10. perinuclear region of cytoplasm Source: AgBase
    11. plasma membrane Source: AgBase
    12. stress fiber Source: AgBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 673672Annexin A6PRO_0000067493Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei30 – 301PhosphotyrosineBy similarity
    Modified residuei63 – 631N6-acetyllysineBy similarity
    Modified residuei68 – 681N6-acetyllysineBy similarity
    Modified residuei75 – 751N6-acetyllysineBy similarity
    Modified residuei81 – 811N6-acetyllysineBy similarity
    Modified residuei201 – 2011PhosphotyrosineBy similarity
    Modified residuei306 – 3061N6-acetyllysineBy similarity
    Modified residuei370 – 3701N6-acetyllysineBy similarity
    Modified residuei418 – 4181N6-acetyllysineBy similarity
    Modified residuei483 – 4831N6-acetyllysineBy similarity
    Modified residuei620 – 6201N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylated in response to growth factor stimulation.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP79134.
    PRIDEiP79134.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000019719.

    Structurei

    Secondary structure

    1
    673
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi52 – 6615
    Helixi70 – 778
    Helixi81 – 9010
    Helixi93 – 10513
    Beta strandi106 – 1094
    Helixi112 – 12110
    Helixi124 – 13815
    Helixi142 – 1476
    Helixi153 – 16311
    Helixi174 – 18714
    Turni188 – 1903
    Beta strandi191 – 1933
    Helixi196 – 20510
    Helixi208 – 22215
    Helixi226 – 2305
    Helixi236 – 25015
    Helixi252 – 26413
    Beta strandi265 – 2684
    Helixi271 – 28010
    Turni281 – 2855
    Helixi286 – 29611
    Beta strandi297 – 2993
    Helixi301 – 3088
    Helixi311 – 32111
    Helixi333 – 34816
    Helixi365 – 37410
    Beta strandi377 – 3804
    Helixi383 – 3908
    Helixi395 – 40915
    Helixi413 – 4208
    Helixi423 – 43311
    Helixi436 – 44712
    Beta strandi449 – 4524
    Helixi455 – 4628
    Helixi467 – 48014
    Beta strandi481 – 4833
    Helixi485 – 4928
    Helixi495 – 50410
    Helixi516 – 52914
    Helixi546 – 5538
    Helixi556 – 57015
    Helixi574 – 5818
    Helixi584 – 61128
    Beta strandi613 – 6164
    Helixi619 – 62810
    Turni629 – 6335
    Helixi634 – 64512
    Helixi649 – 6568
    Helixi659 – 66911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AVCX-ray2.90A46-673[»]
    ProteinModelPortaliP79134.
    SMRiP79134. Positions 10-671.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP79134.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 8961Annexin 1Add
    BLAST
    Repeati101 – 16161Annexin 2Add
    BLAST
    Repeati185 – 24561Annexin 3Add
    BLAST
    Repeati260 – 32061Annexin 4Add
    BLAST
    Repeati372 – 43261Annexin 5Add
    BLAST
    Repeati444 – 50461Annexin 6Add
    BLAST
    Repeati533 – 59361Annexin 7Add
    BLAST
    Repeati608 – 66861Annexin 8Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 8 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    GeneTreeiENSGT00740000115434.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiP79134.
    KOiK17094.
    OMAiEKSLYSM.
    OrthoDBiEOG74XS72.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 8 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002393. AnnexinVI.
    [Graphical view]
    PfamiPF00191. Annexin. 8 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00202. ANNEXINVI.
    SMARTiSM00335. ANX. 8 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P79134-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKPAQGAKY RGSIRDFPDF NPSQDAETLY NAMKGFGSDK EAILELITSR    50
    SNRQRQEICQ NYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYADAKE 100
    IKDAISGIGT DEKCLIEILA SRTNEQIHQL VAAYKDAYER DLEADITGDT 150
    SGHFRKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI 200
    YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR 250
    STAEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 300
    LYSMIKNDTS GEYKKTLLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVAR 350
    VELKGTVRPA GDFNPDADAK ALRKAMKGLG TDEDTIIDII AHRSNAQRQQ 400
    IRQTFKSHFG RDLMADLKSE LSGDLARLIL GLMMPPAHYD AKQLKKAMEG 450
    AGTDEKALIE ILATRTNAEI QAINKAYKED YHKSLEDALS SDTSGHFKRI 500
    LISLATGNRE EGGEDRERAR EDAQVAAEIL EIADTTSGDK SSLETRFMMI 550
    LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDVF VAIVQSVKNK 600
    PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH 650
    QAIEGDTSGH FLKALLAICG GED 673
    Length:673
    Mass (Da):75,907
    Last modified:November 13, 2007 - v2
    Checksum:iAC85A55BEFDF236B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1411D → E in AAB47570. 1 PublicationCurated
    Sequence conflicti181 – 1811V → L in AAB47570. 1 PublicationCurated
    Sequence conflicti391 – 3911A → T in AAB47570. 1 PublicationCurated
    Sequence conflicti484 – 4841S → T in AAB47570. 1 PublicationCurated
    Sequence conflicti558 – 5581H → D in AAB47570. 1 PublicationCurated
    Sequence conflicti567 – 5671I → V in AAB47570. 1 PublicationCurated
    Sequence conflicti618 – 6181D → E in AAB47570. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151391 mRNA. Translation: AAI51392.1.
    U87539 mRNA. Translation: AAB47570.1.
    RefSeqiNP_001096694.1. NM_001103224.1.
    XP_005209618.1. XM_005209561.1.
    UniGeneiBt.5267.

    Genome annotation databases

    EnsembliENSBTAT00000019719; ENSBTAP00000019719; ENSBTAG00000014809.
    GeneIDi327685.
    KEGGibta:327685.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151391 mRNA. Translation: AAI51392.1 .
    U87539 mRNA. Translation: AAB47570.1 .
    RefSeqi NP_001096694.1. NM_001103224.1.
    XP_005209618.1. XM_005209561.1.
    UniGenei Bt.5267.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AVC X-ray 2.90 A 46-673 [» ]
    ProteinModelPortali P79134.
    SMRi P79134. Positions 10-671.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000019719.

    Proteomic databases

    PaxDbi P79134.
    PRIDEi P79134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000019719 ; ENSBTAP00000019719 ; ENSBTAG00000014809 .
    GeneIDi 327685.
    KEGGi bta:327685.

    Organism-specific databases

    CTDi 309.

    Phylogenomic databases

    eggNOGi NOG267770.
    GeneTreei ENSGT00740000115434.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi P79134.
    KOi K17094.
    OMAi EKSLYSM.
    OrthoDBi EOG74XS72.
    TreeFami TF105452.

    Miscellaneous databases

    EvolutionaryTracei P79134.
    NextBioi 20810150.

    Family and domain databases

    Gene3Di 1.10.220.10. 8 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002393. AnnexinVI.
    [Graphical view ]
    Pfami PF00191. Annexin. 8 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00202. ANNEXINVI.
    SMARTi SM00335. ANX. 8 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Ascending colon.
    2. Comera C., Creutz C.E.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-673.
      Tissue: Liver.
    3. "Crystal structure of bovine annexin VI in a calcium-bound state."
      Avila-Sakar A.J., Creutz C.E., Kretsinger R.H.
      Biochim. Biophys. Acta 1387:103-116(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 56-673 IN COMPLEX WITH CALCIUM.

    Entry informationi

    Entry nameiANXA6_BOVIN
    AccessioniPrimary (citable) accession number: P79134
    Secondary accession number(s): A7YY61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Seems to bind one calcium ion with high affinity.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3