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Protein

Annexin A6

Gene

ANXA6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

Miscellaneous

Seems to bind one calcium ion with high affinity.

GO - Molecular functioni

  • actin filament binding Source: AgBase
  • calcium channel activity Source: AgBase
  • calcium-dependent phospholipid binding Source: AgBase
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • cholesterol binding Source: Ensembl
  • chondroitin sulfate binding Source: AgBase
  • enzyme binding Source: AgBase
  • GTP binding Source: Ensembl
  • heparin binding Source: AgBase
  • identical protein binding Source: AgBase
  • ligand-gated ion channel activity Source: Ensembl
  • phosphatidylserine binding Source: AgBase
  • protein homodimerization activity Source: Ensembl
  • signaling receptor activity Source: AgBase

GO - Biological processi

  • apoptotic signaling pathway Source: Ensembl
  • biomineral tissue development Source: AgBase
  • calcium ion import Source: AgBase
  • calcium ion transmembrane transport Source: AgBase
  • calcium ion transport Source: AgBase
  • growth plate cartilage chondrocyte differentiation Source: AgBase
  • mitochondrial calcium ion homeostasis Source: Ensembl
  • negative regulation of sequestering of calcium ion Source: AgBase
  • protein homooligomerization Source: Ensembl
  • regulation of muscle contraction Source: AgBase

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
Annexin VI
Annexin-6
Gene namesi
Name:ANXA6
Synonyms:ANX6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:25968 ANXA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674932 – 673Annexin A6Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei30PhosphotyrosineBy similarity1
Modified residuei63N6-acetyllysineBy similarity1
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei201PhosphotyrosineBy similarity1
Modified residuei306N6-acetyllysineBy similarity1
Modified residuei370N6-acetyllysineBy similarity1
Modified residuei418N6-acetyllysineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei483N6-acetyllysineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei620N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated in response to growth factor stimulation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP79134
PeptideAtlasiP79134
PRIDEiP79134

Expressioni

Gene expression databases

BgeeiENSBTAG00000014809

Interactioni

GO - Molecular functioni

  • actin filament binding Source: AgBase
  • calcium-dependent protein binding Source: AgBase
  • enzyme binding Source: AgBase
  • identical protein binding Source: AgBase
  • protein homodimerization activity Source: Ensembl

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019719

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 32Combined sources11
Beta strandi35 – 37Combined sources3
Helixi40 – 47Combined sources8
Helixi52 – 66Combined sources15
Helixi70 – 77Combined sources8
Helixi81 – 90Combined sources10
Helixi93 – 105Combined sources13
Beta strandi106 – 109Combined sources4
Helixi112 – 121Combined sources10
Helixi124 – 138Combined sources15
Helixi142 – 147Combined sources6
Helixi153 – 163Combined sources11
Helixi174 – 187Combined sources14
Turni188 – 190Combined sources3
Beta strandi191 – 193Combined sources3
Helixi196 – 205Combined sources10
Helixi208 – 222Combined sources15
Helixi226 – 230Combined sources5
Helixi236 – 250Combined sources15
Helixi252 – 264Combined sources13
Beta strandi265 – 268Combined sources4
Helixi271 – 280Combined sources10
Turni281 – 285Combined sources5
Helixi286 – 296Combined sources11
Beta strandi297 – 299Combined sources3
Helixi301 – 308Combined sources8
Helixi311 – 321Combined sources11
Helixi333 – 348Combined sources16
Helixi365 – 374Combined sources10
Beta strandi377 – 380Combined sources4
Helixi383 – 390Combined sources8
Helixi395 – 409Combined sources15
Helixi413 – 420Combined sources8
Helixi423 – 433Combined sources11
Helixi436 – 447Combined sources12
Beta strandi449 – 452Combined sources4
Helixi455 – 462Combined sources8
Helixi467 – 480Combined sources14
Beta strandi481 – 483Combined sources3
Helixi485 – 492Combined sources8
Helixi495 – 504Combined sources10
Helixi516 – 529Combined sources14
Helixi546 – 553Combined sources8
Helixi556 – 570Combined sources15
Helixi574 – 581Combined sources8
Helixi584 – 611Combined sources28
Beta strandi613 – 616Combined sources4
Helixi619 – 628Combined sources10
Turni629 – 633Combined sources5
Helixi634 – 645Combined sources12
Helixi649 – 656Combined sources8
Helixi659 – 669Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVCX-ray2.90A1-673[»]
ProteinModelPortaliP79134
SMRiP79134
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP79134

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 89Annexin 1Add BLAST61
Repeati101 – 161Annexin 2Add BLAST61
Repeati185 – 245Annexin 3Add BLAST61
Repeati260 – 320Annexin 4Add BLAST61
Repeati372 – 432Annexin 5Add BLAST61
Repeati444 – 504Annexin 6Add BLAST61
Repeati533 – 593Annexin 7Add BLAST61
Repeati608 – 668Annexin 8Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP79134
KOiK17094
OMAiLGTRDNT
OrthoDBiEOG091G0H6H
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 8 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002393 ANX6
PANTHERiPTHR10502:SF19 PTHR10502:SF19, 2 hits
PfamiView protein in Pfam
PF00191 Annexin, 8 hits
PRINTSiPR00196 ANNEXIN
PR00202 ANNEXINVI
SMARTiView protein in SMART
SM00335 ANX, 8 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPAQGAKY RGSIRDFPDF NPSQDAETLY NAMKGFGSDK EAILELITSR
60 70 80 90 100
SNRQRQEICQ NYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYADAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQIHQL VAAYKDAYER DLEADITGDT
160 170 180 190 200
SGHFRKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STAEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKTLLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVAR
360 370 380 390 400
VELKGTVRPA GDFNPDADAK ALRKAMKGLG TDEDTIIDII AHRSNAQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMADLKSE LSGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI QAINKAYKED YHKSLEDALS SDTSGHFKRI
510 520 530 540 550
LISLATGNRE EGGEDRERAR EDAQVAAEIL EIADTTSGDK SSLETRFMMI
560 570 580 590 600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDVF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGH FLKALLAICG GED
Length:673
Mass (Da):75,907
Last modified:November 13, 2007 - v2
Checksum:iAC85A55BEFDF236B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141D → E in AAB47570 (Ref. 2) Curated1
Sequence conflicti181V → L in AAB47570 (Ref. 2) Curated1
Sequence conflicti391A → T in AAB47570 (Ref. 2) Curated1
Sequence conflicti484S → T in AAB47570 (Ref. 2) Curated1
Sequence conflicti558H → D in AAB47570 (Ref. 2) Curated1
Sequence conflicti567I → V in AAB47570 (Ref. 2) Curated1
Sequence conflicti618D → E in AAB47570 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151391 mRNA Translation: AAI51392.1
U87539 mRNA Translation: AAB47570.1
RefSeqiNP_001096694.1, NM_001103224.1
XP_005209618.1, XM_005209561.3
XP_010805730.1, XM_010807428.2
UniGeneiBt.5267

Genome annotation databases

EnsembliENSBTAT00000019719; ENSBTAP00000019719; ENSBTAG00000014809
GeneIDi327685
KEGGibta:327685

Similar proteinsi

Entry informationi

Entry nameiANXA6_BOVIN
AccessioniPrimary (citable) accession number: P79134
Secondary accession number(s): A7YY61
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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