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P79134

- ANXA6_BOVIN

UniProt

P79134 - ANXA6_BOVIN

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Protein

Annexin A6

Gene

ANXA6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

GO - Molecular functioni

  1. actin filament binding Source: AgBase
  2. calcium channel activity Source: AgBase
  3. calcium-dependent phospholipid binding Source: AgBase
  4. calcium-dependent protein binding Source: AgBase
  5. calcium ion binding Source: InterPro
  6. cholesterol binding Source: Ensembl
  7. chondroitin sulfate binding Source: AgBase
  8. enzyme binding Source: AgBase
  9. GTP binding Source: Ensembl
  10. heparin binding Source: AgBase
  11. identical protein binding Source: AgBase
  12. ligand-gated ion channel activity Source: Ensembl
  13. receptor activity Source: AgBase

GO - Biological processi

  1. biomineral tissue development Source: AgBase
  2. calcium ion import Source: AgBase
  3. calcium ion transmembrane transport Source: GOC
  4. calcium ion transport Source: AgBase
  5. growth plate cartilage chondrocyte differentiation Source: AgBase
  6. protein homooligomerization Source: Ensembl
  7. regulation of muscle contraction Source: AgBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
Annexin VI
Annexin-6
Gene namesi
Name:ANXA6
Synonyms:ANX6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Cytoplasm By similarity. Melanosome By similarity

GO - Cellular componenti

  1. chromaffin granule membrane Source: AgBase
  2. cytoplasm Source: AgBase
  3. extracellular vesicular exosome Source: Ensembl
  4. focal adhesion Source: AgBase
  5. integral component of membrane Source: AgBase
  6. late endosome membrane Source: Ensembl
  7. lysosomal membrane Source: Ensembl
  8. membrane Source: AgBase
  9. membrane-bounded vesicle Source: AgBase
  10. mitochondrial crista Source: AgBase
  11. perinuclear region of cytoplasm Source: AgBase
  12. plasma membrane Source: AgBase
  13. stress fiber Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 673672Annexin A6PRO_0000067493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei30 – 301PhosphotyrosineBy similarity
Modified residuei63 – 631N6-acetyllysineBy similarity
Modified residuei68 – 681N6-acetyllysineBy similarity
Modified residuei75 – 751N6-acetyllysineBy similarity
Modified residuei81 – 811N6-acetyllysineBy similarity
Modified residuei201 – 2011PhosphotyrosineBy similarity
Modified residuei306 – 3061N6-acetyllysineBy similarity
Modified residuei370 – 3701N6-acetyllysineBy similarity
Modified residuei418 – 4181N6-acetyllysineBy similarity
Modified residuei483 – 4831N6-acetyllysineBy similarity
Modified residuei620 – 6201N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylated in response to growth factor stimulation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP79134.
PRIDEiP79134.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019719.

Structurei

Secondary structure

1
673
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 6615
Helixi70 – 778
Helixi81 – 9010
Helixi93 – 10513
Beta strandi106 – 1094
Helixi112 – 12110
Helixi124 – 13815
Helixi142 – 1476
Helixi153 – 16311
Helixi174 – 18714
Turni188 – 1903
Beta strandi191 – 1933
Helixi196 – 20510
Helixi208 – 22215
Helixi226 – 2305
Helixi236 – 25015
Helixi252 – 26413
Beta strandi265 – 2684
Helixi271 – 28010
Turni281 – 2855
Helixi286 – 29611
Beta strandi297 – 2993
Helixi301 – 3088
Helixi311 – 32111
Helixi333 – 34816
Helixi365 – 37410
Beta strandi377 – 3804
Helixi383 – 3908
Helixi395 – 40915
Helixi413 – 4208
Helixi423 – 43311
Helixi436 – 44712
Beta strandi449 – 4524
Helixi455 – 4628
Helixi467 – 48014
Beta strandi481 – 4833
Helixi485 – 4928
Helixi495 – 50410
Helixi516 – 52914
Helixi546 – 5538
Helixi556 – 57015
Helixi574 – 5818
Helixi584 – 61128
Beta strandi613 – 6164
Helixi619 – 62810
Turni629 – 6335
Helixi634 – 64512
Helixi649 – 6568
Helixi659 – 66911

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AVCX-ray2.90A46-673[»]
ProteinModelPortaliP79134.
SMRiP79134. Positions 10-671.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP79134.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 8961Annexin 1Add
BLAST
Repeati101 – 16161Annexin 2Add
BLAST
Repeati185 – 24561Annexin 3Add
BLAST
Repeati260 – 32061Annexin 4Add
BLAST
Repeati372 – 43261Annexin 5Add
BLAST
Repeati444 – 50461Annexin 6Add
BLAST
Repeati533 – 59361Annexin 7Add
BLAST
Repeati608 – 66861Annexin 8Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 8 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG267770.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP79134.
KOiK17094.
OMAiEKSLYSM.
OrthoDBiEOG74XS72.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79134-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKPAQGAKY RGSIRDFPDF NPSQDAETLY NAMKGFGSDK EAILELITSR
60 70 80 90 100
SNRQRQEICQ NYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYADAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQIHQL VAAYKDAYER DLEADITGDT
160 170 180 190 200
SGHFRKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STAEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKTLLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVAR
360 370 380 390 400
VELKGTVRPA GDFNPDADAK ALRKAMKGLG TDEDTIIDII AHRSNAQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMADLKSE LSGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI QAINKAYKED YHKSLEDALS SDTSGHFKRI
510 520 530 540 550
LISLATGNRE EGGEDRERAR EDAQVAAEIL EIADTTSGDK SSLETRFMMI
560 570 580 590 600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDVF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGH FLKALLAICG GED
Length:673
Mass (Da):75,907
Last modified:November 13, 2007 - v2
Checksum:iAC85A55BEFDF236B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411D → E in AAB47570. 1 PublicationCurated
Sequence conflicti181 – 1811V → L in AAB47570. 1 PublicationCurated
Sequence conflicti391 – 3911A → T in AAB47570. 1 PublicationCurated
Sequence conflicti484 – 4841S → T in AAB47570. 1 PublicationCurated
Sequence conflicti558 – 5581H → D in AAB47570. 1 PublicationCurated
Sequence conflicti567 – 5671I → V in AAB47570. 1 PublicationCurated
Sequence conflicti618 – 6181D → E in AAB47570. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151391 mRNA. Translation: AAI51392.1.
U87539 mRNA. Translation: AAB47570.1.
RefSeqiNP_001096694.1. NM_001103224.1.
XP_005209618.1. XM_005209561.1.
UniGeneiBt.5267.

Genome annotation databases

EnsembliENSBTAT00000019719; ENSBTAP00000019719; ENSBTAG00000014809.
GeneIDi327685.
KEGGibta:327685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151391 mRNA. Translation: AAI51392.1 .
U87539 mRNA. Translation: AAB47570.1 .
RefSeqi NP_001096694.1. NM_001103224.1.
XP_005209618.1. XM_005209561.1.
UniGenei Bt.5267.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AVC X-ray 2.90 A 46-673 [» ]
ProteinModelPortali P79134.
SMRi P79134. Positions 10-671.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000019719.

Proteomic databases

PaxDbi P79134.
PRIDEi P79134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000019719 ; ENSBTAP00000019719 ; ENSBTAG00000014809 .
GeneIDi 327685.
KEGGi bta:327685.

Organism-specific databases

CTDi 309.

Phylogenomic databases

eggNOGi NOG267770.
GeneTreei ENSGT00760000118972.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P79134.
KOi K17094.
OMAi EKSLYSM.
OrthoDBi EOG74XS72.
TreeFami TF105452.

Miscellaneous databases

EvolutionaryTracei P79134.
NextBioi 20810150.

Family and domain databases

Gene3Di 1.10.220.10. 8 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view ]
Pfami PF00191. Annexin. 8 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTi SM00335. ANX. 8 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.
  2. Comera C., Creutz C.E.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-673.
    Tissue: Liver.
  3. "Crystal structure of bovine annexin VI in a calcium-bound state."
    Avila-Sakar A.J., Creutz C.E., Kretsinger R.H.
    Biochim. Biophys. Acta 1387:103-116(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 56-673 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiANXA6_BOVIN
AccessioniPrimary (citable) accession number: P79134
Secondary accession number(s): A7YY61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3