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Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi60Manganese 2By similarity1
Metal bindingi61Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi439Manganese 2By similarity1
Metal bindingi494Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Alternative name(s):
Magnesium-dependent calcium inhibitable phosphatase
Short name:
MCPP
Protein phosphatase 1B
Protein phosphatase 2C isoform gamma
Short name:
PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene namesi
Name:PPM1G
Synonyms:PPM1C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

  • Cytoplasm Curated
  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000577492 – 543Protein phosphatase 1GAdd BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei22Omega-N-methylarginineBy similarity1
Modified residuei122PhosphothreonineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei381N6-acetyllysineBy similarity1
Modified residuei525PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP79126.
PRIDEiP79126.

Expressioni

Gene expression databases

BgeeiENSBTAG00000019522.

Interactioni

Subunit structurei

Interacts with NOL3; may dephosphorylate NOL3.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026003.

Structurei

3D structure databases

ProteinModelPortaliP79126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 503PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST478

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 320Glu-richPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0699. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00860000133868.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiP79126.
KOiK17499.
OMAiHNCILNF.
OrthoDBiEOG091G0D0W.
TreeFamiTF354280.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLSQPNT VKCSGDGVGA SRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA
110 120 130 140 150
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCHKGAPH SKSGAGTGEE PGSQGLNGEA GPEDPSRETS
210 220 230 240 250
AEENGPTAKA HTGLSSNSEC GTEAGQGGEP GTPTGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDEEEEM MVPGMEGKEE PGSDSGTTAV VALIRGKQLI VANAGDSRCV
360 370 380 390 400
VSEAGKALDM SYDHKPEDEV ELARIKNAGG KVTMDGRVNG GLNLSRAIGD
410 420 430 440 450
HFYKRNKNLP PEEQMISALP DIKVLTLTDD HEFMVIACDG IWNVMSSQEV
460 470 480 490 500
IDFIQSKISQ RDENGELRLL SSIVEELLDQ CLAPDTSGDG TGCDNMTCII
510 520 530 540
ICFKPRNTAA PQPESGKRKL EEVLSTEGAE ENGNSDKKKA KRD
Length:543
Mass (Da):58,607
Last modified:May 15, 2007 - v2
Checksum:iDFBDFEDBA2B673A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47P → Q in AAB39357 (Ref. 1) Curated1
Sequence conflicti203E → V in AAB39357 (Ref. 1) Curated1
Sequence conflicti252A → D in AAB39357 (Ref. 1) Curated1
Sequence conflicti476E → Y in AAB39357 (Ref. 1) Curated1
Sequence conflicti531E → Q in AAB39357 (Ref. 1) Curated1
Sequence conflicti534N → H in AAB39357 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81159 mRNA. Translation: AAB39357.1.
BC103458 mRNA. Translation: AAI03459.1.
RefSeqiNP_777226.2. NM_174801.4.
UniGeneiBt.49531.

Genome annotation databases

EnsembliENSBTAT00000026003; ENSBTAP00000026003; ENSBTAG00000019522.
GeneIDi286880.
KEGGibta:286880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81159 mRNA. Translation: AAB39357.1.
BC103458 mRNA. Translation: AAI03459.1.
RefSeqiNP_777226.2. NM_174801.4.
UniGeneiBt.49531.

3D structure databases

ProteinModelPortaliP79126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026003.

Proteomic databases

PaxDbiP79126.
PRIDEiP79126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000026003; ENSBTAP00000026003; ENSBTAG00000019522.
GeneIDi286880.
KEGGibta:286880.

Organism-specific databases

CTDi5496.

Phylogenomic databases

eggNOGiKOG0699. Eukaryota.
COG0631. LUCA.
GeneTreeiENSGT00860000133868.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiP79126.
KOiK17499.
OMAiHNCILNF.
OrthoDBiEOG091G0D0W.
TreeFamiTF354280.

Gene expression databases

BgeeiENSBTAG00000019522.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPM1G_BOVIN
AccessioniPrimary (citable) accession number: P79126
Secondary accession number(s): Q3ZBB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 15, 2007
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.