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P79126

- PPM1G_BOVIN

UniProt

P79126 - PPM1G_BOVIN

Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (15 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Manganese 1By similarity
    Metal bindingi60 – 601Manganese 2By similarity
    Metal bindingi61 – 611Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi439 – 4391Manganese 2By similarity
    Metal bindingi494 – 4941Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl
    2. peptidyl-threonine dephosphorylation Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1G (EC:3.1.3.16)
    Alternative name(s):
    Magnesium-dependent calcium inhibitable phosphatase
    Short name:
    MCPP
    Protein phosphatase 1B
    Protein phosphatase 2C isoform gamma
    Short name:
    PP2C-gamma
    Protein phosphatase magnesium-dependent 1 gamma
    Gene namesi
    Name:PPM1G
    Synonyms:PPM1C
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 11

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 543543Protein phosphatase 1GPRO_0000057749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831PhosphoserineBy similarity
    Modified residuei381 – 3811N6-acetyllysineBy similarity
    Modified residuei525 – 5251PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiP79126.

    Structurei

    3D structure databases

    ProteinModelPortaliP79126.
    SMRiP79126. Positions 308-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi258 – 32467Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi266 – 2727Poly-Glu
    Compositional biasi306 – 3094Poly-Glu

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00730000110861.
    HOGENOMiHOG000233896.
    HOVERGENiHBG053647.
    InParanoidiP79126.
    KOiK17499.
    OMAiMISAMPD.
    OrthoDBiEOG7034GD.
    TreeFamiTF354280.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79126-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAYLSQPNT VKCSGDGVGA SRLPLPYGFS AMQGWRVSME DAHNCIPELD    50
    SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA 100
    IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT 150
    MTIEELLTRY GQNCHKGAPH SKSGAGTGEE PGSQGLNGEA GPEDPSRETS 200
    AEENGPTAKA HTGLSSNSEC GTEAGQGGEP GTPTGEAGPS CSSASDKLPR 250
    VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300
    AEEDDEEEEM MVPGMEGKEE PGSDSGTTAV VALIRGKQLI VANAGDSRCV 350
    VSEAGKALDM SYDHKPEDEV ELARIKNAGG KVTMDGRVNG GLNLSRAIGD 400
    HFYKRNKNLP PEEQMISALP DIKVLTLTDD HEFMVIACDG IWNVMSSQEV 450
    IDFIQSKISQ RDENGELRLL SSIVEELLDQ CLAPDTSGDG TGCDNMTCII 500
    ICFKPRNTAA PQPESGKRKL EEVLSTEGAE ENGNSDKKKA KRD 543
    Length:543
    Mass (Da):58,607
    Last modified:May 15, 2007 - v2
    Checksum:iDFBDFEDBA2B673A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti47 – 471P → Q in AAB39357. 1 PublicationCurated
    Sequence conflicti203 – 2031E → V in AAB39357. 1 PublicationCurated
    Sequence conflicti252 – 2521A → D in AAB39357. 1 PublicationCurated
    Sequence conflicti476 – 4761E → Y in AAB39357. 1 PublicationCurated
    Sequence conflicti531 – 5311E → Q in AAB39357. 1 PublicationCurated
    Sequence conflicti534 – 5341N → H in AAB39357. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81159 mRNA. Translation: AAB39357.1.
    BC103458 mRNA. Translation: AAI03459.1.
    RefSeqiNP_777226.2. NM_174801.4.
    UniGeneiBt.49531.

    Genome annotation databases

    EnsembliENSBTAT00000026003; ENSBTAP00000026003; ENSBTAG00000019522.
    GeneIDi286880.
    KEGGibta:286880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U81159 mRNA. Translation: AAB39357.1 .
    BC103458 mRNA. Translation: AAI03459.1 .
    RefSeqi NP_777226.2. NM_174801.4.
    UniGenei Bt.49531.

    3D structure databases

    ProteinModelPortali P79126.
    SMRi P79126. Positions 308-504.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P79126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000026003 ; ENSBTAP00000026003 ; ENSBTAG00000019522 .
    GeneIDi 286880.
    KEGGi bta:286880.

    Organism-specific databases

    CTDi 5496.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00730000110861.
    HOGENOMi HOG000233896.
    HOVERGENi HBG053647.
    InParanoidi P79126.
    KOi K17499.
    OMAi MISAMPD.
    OrthoDBi EOG7034GD.
    TreeFami TF354280.

    Miscellaneous databases

    NextBioi 20806526.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characteristics of a Mg-dependent, calcium-inhibitable serine/threonine protein phosphatase revealed by its cDNA."
      Huang C.Y., Qin K.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiPPM1G_BOVIN
    AccessioniPrimary (citable) accession number: P79126
    Secondary accession number(s): Q3ZBB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 15, 2007
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3