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P79126

- PPM1G_BOVIN

UniProt

P79126 - PPM1G_BOVIN

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Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Manganese 1By similarity
Metal bindingi60 – 601Manganese 2By similarity
Metal bindingi61 – 611Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi439 – 4391Manganese 2By similarity
Metal bindingi494 – 4941Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. cell cycle arrest Source: Ensembl
  2. peptidyl-threonine dephosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Alternative name(s):
Magnesium-dependent calcium inhibitable phosphatase
Short name:
MCPP
Protein phosphatase 1B
Protein phosphatase 2C isoform gamma
Short name:
PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene namesi
Name:PPM1G
Synonyms:PPM1C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 11

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Protein phosphatase 1GPRO_0000057749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831PhosphoserineBy similarity
Modified residuei381 – 3811N6-acetyllysineBy similarity
Modified residuei525 – 5251PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP79126.

Expressioni

Gene expression databases

ExpressionAtlasiP79126. baseline.

Structurei

3D structure databases

ProteinModelPortaliP79126.
SMRiP79126. Positions 308-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 32467Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi266 – 2727Poly-Glu
Compositional biasi306 – 3094Poly-Glu

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00760000119393.
HOGENOMiHOG000233896.
HOVERGENiHBG053647.
InParanoidiP79126.
KOiK17499.
OMAiMISAMPD.
OrthoDBiEOG7034GD.
TreeFamiTF354280.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79126-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAYLSQPNT VKCSGDGVGA SRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA
110 120 130 140 150
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCHKGAPH SKSGAGTGEE PGSQGLNGEA GPEDPSRETS
210 220 230 240 250
AEENGPTAKA HTGLSSNSEC GTEAGQGGEP GTPTGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDEEEEM MVPGMEGKEE PGSDSGTTAV VALIRGKQLI VANAGDSRCV
360 370 380 390 400
VSEAGKALDM SYDHKPEDEV ELARIKNAGG KVTMDGRVNG GLNLSRAIGD
410 420 430 440 450
HFYKRNKNLP PEEQMISALP DIKVLTLTDD HEFMVIACDG IWNVMSSQEV
460 470 480 490 500
IDFIQSKISQ RDENGELRLL SSIVEELLDQ CLAPDTSGDG TGCDNMTCII
510 520 530 540
ICFKPRNTAA PQPESGKRKL EEVLSTEGAE ENGNSDKKKA KRD
Length:543
Mass (Da):58,607
Last modified:May 15, 2007 - v2
Checksum:iDFBDFEDBA2B673A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471P → Q in AAB39357. 1 PublicationCurated
Sequence conflicti203 – 2031E → V in AAB39357. 1 PublicationCurated
Sequence conflicti252 – 2521A → D in AAB39357. 1 PublicationCurated
Sequence conflicti476 – 4761E → Y in AAB39357. 1 PublicationCurated
Sequence conflicti531 – 5311E → Q in AAB39357. 1 PublicationCurated
Sequence conflicti534 – 5341N → H in AAB39357. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U81159 mRNA. Translation: AAB39357.1.
BC103458 mRNA. Translation: AAI03459.1.
RefSeqiNP_777226.2. NM_174801.4.
UniGeneiBt.49531.

Genome annotation databases

EnsembliENSBTAT00000026003; ENSBTAP00000026003; ENSBTAG00000019522.
GeneIDi286880.
KEGGibta:286880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U81159 mRNA. Translation: AAB39357.1 .
BC103458 mRNA. Translation: AAI03459.1 .
RefSeqi NP_777226.2. NM_174801.4.
UniGenei Bt.49531.

3D structure databases

ProteinModelPortali P79126.
SMRi P79126. Positions 308-504.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P79126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000026003 ; ENSBTAP00000026003 ; ENSBTAG00000019522 .
GeneIDi 286880.
KEGGi bta:286880.

Organism-specific databases

CTDi 5496.

Phylogenomic databases

eggNOGi COG0631.
GeneTreei ENSGT00760000119393.
HOGENOMi HOG000233896.
HOVERGENi HBG053647.
InParanoidi P79126.
KOi K17499.
OMAi MISAMPD.
OrthoDBi EOG7034GD.
TreeFami TF354280.

Miscellaneous databases

NextBioi 20806526.

Gene expression databases

ExpressionAtlasi P79126. baseline.

Family and domain databases

Gene3Di 3.60.40.10. 2 hits.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characteristics of a Mg-dependent, calcium-inhibitable serine/threonine protein phosphatase revealed by its cDNA."
    Huang C.Y., Qin K.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiPPM1G_BOVIN
AccessioniPrimary (citable) accession number: P79126
Secondary accession number(s): Q3ZBB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 15, 2007
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3