Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi60Manganese 2By similarity1
Metal bindingi61Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi439Manganese 2By similarity1
Metal bindingi494Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Alternative name(s):
Magnesium-dependent calcium inhibitable phosphatase
Short name:
MCPP
Protein phosphatase 1B
Protein phosphatase 2C isoform gamma
Short name:
PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene namesi
Name:PPM1G
Synonyms:PPM1C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:33213 PPM1G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000577492 – 543Protein phosphatase 1GAdd BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei22Omega-N-methylarginineBy similarity1
Modified residuei122PhosphothreonineBy similarity1
Modified residuei183PhosphoserineBy similarity1
Modified residuei381N6-acetyllysineBy similarity1
Modified residuei525PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP79126
PRIDEiP79126

Expressioni

Gene expression databases

BgeeiENSBTAG00000019522

Interactioni

Subunit structurei

Interacts with NOL3; may dephosphorylate NOL3.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026003

Structurei

3D structure databases

ProteinModelPortaliP79126
SMRiP79126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 503PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST478

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 320Glu-richPROSITE-ProRule annotationAdd BLAST63

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0699 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00910000144272
HOGENOMiHOG000233896
HOVERGENiHBG053647
InParanoidiP79126
KOiK17499
OMAiGWRNSQE
OrthoDBiEOG091G0D0W
TreeFamiTF354280

Family and domain databases

CDDicd00143 PP2Cc, 2 hits
Gene3Di3.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 2 hits
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 2 hits
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYLSQPNT VKCSGDGVGA SRLPLPYGFS AMQGWRVSME DAHNCIPELD
60 70 80 90 100
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA
110 120 130 140 150
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT
160 170 180 190 200
MTIEELLTRY GQNCHKGAPH SKSGAGTGEE PGSQGLNGEA GPEDPSRETS
210 220 230 240 250
AEENGPTAKA HTGLSSNSEC GTEAGQGGEP GTPTGEAGPS CSSASDKLPR
260 270 280 290 300
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE
310 320 330 340 350
AEEDDEEEEM MVPGMEGKEE PGSDSGTTAV VALIRGKQLI VANAGDSRCV
360 370 380 390 400
VSEAGKALDM SYDHKPEDEV ELARIKNAGG KVTMDGRVNG GLNLSRAIGD
410 420 430 440 450
HFYKRNKNLP PEEQMISALP DIKVLTLTDD HEFMVIACDG IWNVMSSQEV
460 470 480 490 500
IDFIQSKISQ RDENGELRLL SSIVEELLDQ CLAPDTSGDG TGCDNMTCII
510 520 530 540
ICFKPRNTAA PQPESGKRKL EEVLSTEGAE ENGNSDKKKA KRD
Length:543
Mass (Da):58,607
Last modified:May 15, 2007 - v2
Checksum:iDFBDFEDBA2B673A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47P → Q in AAB39357 (Ref. 1) Curated1
Sequence conflicti203E → V in AAB39357 (Ref. 1) Curated1
Sequence conflicti252A → D in AAB39357 (Ref. 1) Curated1
Sequence conflicti476E → Y in AAB39357 (Ref. 1) Curated1
Sequence conflicti531E → Q in AAB39357 (Ref. 1) Curated1
Sequence conflicti534N → H in AAB39357 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81159 mRNA Translation: AAB39357.1
BC103458 mRNA Translation: AAI03459.1
RefSeqiNP_777226.2, NM_174801.4
UniGeneiBt.49531

Genome annotation databases

EnsembliENSBTAT00000026003; ENSBTAP00000026003; ENSBTAG00000019522
GeneIDi286880
KEGGibta:286880

Similar proteinsi

Entry informationi

Entry nameiPPM1G_BOVIN
AccessioniPrimary (citable) accession number: P79126
Secondary accession number(s): Q3ZBB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 15, 2007
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health