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P79126 (PPM1G_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1G

EC=3.1.3.16
Alternative name(s):
Magnesium-dependent calcium inhibitable phosphatase
Short name=MCPP
Protein phosphatase 1B
Protein phosphatase 2C isoform gamma
Short name=PP2C-gamma
Protein phosphatase magnesium-dependent 1 gamma
Gene names
Name:PPM1G
Synonyms:PPM1C
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length543 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the PP2C family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 543543Protein phosphatase 1G
PRO_0000057749

Regions

Compositional bias258 – 32467Asp/Glu-rich (acidic)
Compositional bias266 – 2727Poly-Glu
Compositional bias306 – 3094Poly-Glu

Sites

Metal binding601Manganese 1 By similarity
Metal binding601Manganese 2 By similarity
Metal binding611Manganese 1; via carbonyl oxygen By similarity
Metal binding4391Manganese 2 By similarity
Metal binding4941Manganese 2 By similarity

Amino acid modifications

Modified residue1831Phosphoserine By similarity
Modified residue3811N6-acetyllysine By similarity
Modified residue5251Phosphoserine By similarity

Experimental info

Sequence conflict471P → Q in AAB39357. Ref.1
Sequence conflict2031E → V in AAB39357. Ref.1
Sequence conflict2521A → D in AAB39357. Ref.1
Sequence conflict4761E → Y in AAB39357. Ref.1
Sequence conflict5311E → Q in AAB39357. Ref.1
Sequence conflict5341N → H in AAB39357. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P79126 [UniParc].

Last modified May 15, 2007. Version 2.
Checksum: DFBDFEDBA2B673A3

FASTA54358,607
        10         20         30         40         50         60 
MGAYLSQPNT VKCSGDGVGA SRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 

        70         80         90        100        110        120 
GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 

       130        140        150        160        170        180 
PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGAPH SKSGAGTGEE 

       190        200        210        220        230        240 
PGSQGLNGEA GPEDPSRETS AEENGPTAKA HTGLSSNSEC GTEAGQGGEP GTPTGEAGPS 

       250        260        270        280        290        300 
CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 

       310        320        330        340        350        360 
AEEDDEEEEM MVPGMEGKEE PGSDSGTTAV VALIRGKQLI VANAGDSRCV VSEAGKALDM 

       370        380        390        400        410        420 
SYDHKPEDEV ELARIKNAGG KVTMDGRVNG GLNLSRAIGD HFYKRNKNLP PEEQMISALP 

       430        440        450        460        470        480 
DIKVLTLTDD HEFMVIACDG IWNVMSSQEV IDFIQSKISQ RDENGELRLL SSIVEELLDQ 

       490        500        510        520        530        540 
CLAPDTSGDG TGCDNMTCII ICFKPRNTAA PQPESGKRKL EEVLSTEGAE ENGNSDKKKA 


KRD 

« Hide

References

« Hide 'large scale' references
[1]"Characteristics of a Mg-dependent, calcium-inhibitable serine/threonine protein phosphatase revealed by its cDNA."
Huang C.Y., Qin K.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U81159 mRNA. Translation: AAB39357.1.
BC103458 mRNA. Translation: AAI03459.1.
RefSeqNP_777226.2. NM_174801.4.
UniGeneBt.49531.

3D structure databases

ProteinModelPortalP79126.
SMRP79126. Positions 308-504.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP79126.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000026003; ENSBTAP00000026003; ENSBTAG00000019522.
GeneID286880.
KEGGbta:286880.

Organism-specific databases

CTD5496.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00730000110861.
HOGENOMHOG000233896.
HOVERGENHBG053647.
InParanoidP79126.
KOK17499.
OMAMISAMPD.
OrthoDBEOG7034GD.
TreeFamTF354280.

Family and domain databases

Gene3D3.60.40.10. 2 hits.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 2 hits.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 2 hits.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806526.

Entry information

Entry namePPM1G_BOVIN
AccessionPrimary (citable) accession number: P79126
Secondary accession number(s): Q3ZBB4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 15, 2007
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families