P79113 (NPY2R_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuropeptide Y receptor type 2
Short name=NPY2-R

Alternative name(s):
NPY-Y2 receptor
Short name=Y2 receptor

Gene names

Name:

NPY2R

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for neuropeptide Y and peptide YY.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	neuropeptide Y receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Neuropeptide Y receptor type 2		PRO_0000069926
Regions
	Topological domain	1 – 54	54	Extracellular Potential
	Transmembrane	55 – 75	21	Helical; Name=1; Potential
	Topological domain	76 – 89	14	Cytoplasmic Potential
	Transmembrane	90 – 110	21	Helical; Name=2; Potential
	Topological domain	111 – 127	17	Extracellular Potential
	Transmembrane	128 – 148	21	Helical; Name=3; Potential
	Topological domain	149 – 168	20	Cytoplasmic Potential
	Transmembrane	169 – 189	21	Helical; Name=4; Potential
	Topological domain	190 – 219	30	Extracellular Potential
	Transmembrane	220 – 240	21	Helical; Name=5; Potential
	Topological domain	241 – 271	31	Cytoplasmic Potential
	Transmembrane	272 – 292	21	Helical; Name=6; Potential
	Topological domain	293 – 307	15	Extracellular Potential
	Transmembrane	308 – 328	21	Helical; Name=7; Potential
	Topological domain	329 – 384	56	Cytoplasmic Potential
Amino acid modifications
	Lipidation	345	1	S-palmitoyl cysteine Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Disulfide bond	126 ↔ 206		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P79113 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 468D19CBA8F29681	FASTA	384	42,943
	10 20 30 40 50 60 MKMGPLGAEA DENQTVEEMK VDQFGPGHTT LPGELAPDSE PELIDSTKLI EVQVVLILAY 70 80 90 100 110 120 CSIILLGVIG NSLVIHVVIK FKSMRTVTNF FIANLAVADL LVNTLCLPFT LTYTLMGEWK 130 140 150 160 170 180 MGPVLCHLVP YAQGLAVQVS TITLTVIALD RHRCIVYHLE SKISKQISFL IIGLAWGVSA 190 200 210 220 230 240 LLASPLAIFR EYSLIEIIPD FEIVACTEKW PGEEKGIYGT IYSLSSLLIL YVLPLGIISF 250 260 270 280 290 300 SYTRIWSKLK NHVSPGAAHD HYHQRRQKTT KMLVCVVVVF AVSWLPLHAF QLAVDIDSHV 310 320 330 340 350 360 LDLKEYKLIF TVFHIIAMCS TFANPLLYGW MNSNYRKAFL SAFRCEQRLD AIHSEVSVTF 370 380 KAKKHLQVTK NNGPNDSFTE TTNV

References

[1]	Ammar D.A., Kolakowski L.F. Jr., Eadie D.M., Wong D.J., Ma Y.Y., Yang-Feng T.L., Thompson D.A. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U50144 mRNA. Translation: AAB40600.1.
IPI	IPI00686523.
RefSeq	NP_776826.1. NM_174401.2.
UniGene	Bt.578.
3D structure databases
ProteinModelPortal	P79113.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P79113.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	281943.
KEGG	bta:281943.
Organism-specific databases
CTD	4887.
Phylogenomic databases
eggNOG	NOG267229.
HOGENOM	HOG000050229.
HOVERGEN	HBG105675.
InParanoid	P79113.
KO	K04205.
OrthoDB	EOG4JT05M.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001358. NPY2_rcpt. IPR000611. NPY_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01014. NRPEPTIDEY2R. PR01012. NRPEPTIDEYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805820.

Entry information

Entry name

NPY2R_BOVIN

Accession

Primary (citable) accession number: P79113

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program