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Protein

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Gene

PAFAH2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.2 Publications

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei236Nucleophile1 Publication1
Active sitei259Charge relay systemPROSITE-ProRule annotation1
Active sitei314Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-BTA-418346 Platelet homeostasis

Protein family/group databases

ESTHERibovin-paf2 PAF-Acetylhydrolase

Chemistry databases

SwissLipidsiSLP:000000690

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic1 Publication (EC:3.1.1.472 Publications)
Alternative name(s):
Serine-dependent phospholipase A2By similarity
Short name:
SD-PLA2Curated
Gene namesi
Name:PAFAH2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:32552 PAFAH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi236S → C: Loss of catalytic activity. Loss of protection against reactive oxygen species (ROS)-induced apoptosis. No defect in ROS-induced membrane translocation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000903822 – 392Platelet-activating factor acetylhydrolase 2, cytoplasmicAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP79106
PeptideAtlasiP79106
PRIDEiP79106

Expressioni

Tissue specificityi

Expressed at highest levels in liver and at lower levels in other tissues.1 Publication

Gene expression databases

BgeeiENSBTAG00000005105

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006727

Structurei

3D structure databases

ProteinModelPortaliP79106
SMRiP79106
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Phylogenomic databases

eggNOGiKOG3847 Eukaryota
ENOG4111FH0 LUCA
GeneTreeiENSGT00390000005233
HOGENOMiHOG000008053
HOVERGENiHBG001322
InParanoidiP79106
KOiK01062
OMAiCMELASR
OrthoDBiEOG091G08C2
TreeFamiTF313831

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR005065 PAF_acetylhydro-like
IPR016715 PAF_acetylhydro_eukaryote
PANTHERiPTHR10272 PTHR10272, 1 hit
PfamiView protein in Pfam
PF03403 PAF-AH_p_II, 1 hit
PIRSFiPIRSF018169 PAF_acetylhydrolase, 1 hit
SUPFAMiSSF53474 SSF53474, 2 hits
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVNQSVSFP PVTGPHLVGC GDVMEGQSLQ GSFFRLFYPC QEAEETSEQP
60 70 80 90 100
LWIPRYEYCA GLAEYLKFNK RWGGLLFNLG VGSCRLPVSW NGPFKTKDSG
110 120 130 140 150
YPLIIFSHGM GAFRTVYSAF CMELASRGFV VAVPEHRDGS AAATCFCKQT
160 170 180 190 200
PEENQPDNEA LKEEWIPHRQ IEEGEKEFYV RNYQVHQRVS ECVRVLKILQ
210 220 230 240 250
EVTAGQAVLN ILPGGLDLMT LKGGIDVSRV AVMGHSFGGA TAILALAKEM
260 270 280 290 300
QFRCAVALDA WMFPLEHDFY PTARGPIFFI NAEKFQTVET VNLMKKICDQ
310 320 330 340 350
HHQSRIITVL GSVHRSLTDF VFVAGNWISK FFSSHTRGSL DPYEGQETVV
360 370 380 390
RAMLAFLQKH LDLKEDYDQW NNFIEGIGPS LTPGAPHHLS SL
Length:392
Mass (Da):43,865
Last modified:May 1, 1997 - v1
Checksum:i1DEACA2ADFA4CEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87559 mRNA Translation: BAA13419.1
BT020849 mRNA Translation: AAX08866.1
BC105148 mRNA Translation: AAI05149.1
RefSeqiNP_776995.1, NM_174570.2
XP_015315520.1, XM_015460034.1
UniGeneiBt.103232
Bt.4013

Genome annotation databases

EnsembliENSBTAT00000006727; ENSBTAP00000006727; ENSBTAG00000005105
ENSBTAT00000065543; ENSBTAP00000056542; ENSBTAG00000005105
GeneIDi282299
KEGGibta:282299

Similar proteinsi

Entry informationi

Entry nameiPAFA2_BOVIN
AccessioniPrimary (citable) accession number: P79106
Secondary accession number(s): Q5E9S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health