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P79106

- PAFA2_BOVIN

UniProt

P79106 - PAFA2_BOVIN

Protein

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Gene

PAFAH2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.

    Catalytic activityi

    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei236 – 2361NucleophileBy similarity
    Active sitei259 – 2591Charge relay systemPROSITE-ProRule annotation
    Active sitei314 – 3141Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC:3.1.1.47)
    Alternative name(s):
    Serine-dependent phospholipase A2
    Short name:
    SD-PLA2
    Gene namesi
    Name:PAFAH2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Platelet-activating factor acetylhydrolase 2, cytoplasmicPRO_0000090382Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed at highest levels in liver and at lower levels in other tissues.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000006727.

    Structurei

    3D structure databases

    ProteinModelPortaliP79106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serine esterase family.Curated

    Phylogenomic databases

    eggNOGiCOG4188.
    GeneTreeiENSGT00390000005233.
    HOGENOMiHOG000008053.
    HOVERGENiHBG001322.
    InParanoidiP79106.
    KOiK01062.
    OMAiQFRCAVA.
    OrthoDBiEOG7MSMQ5.
    TreeFamiTF313831.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view]
    PANTHERiPTHR10272. PTHR10272. 1 hit.
    PfamiPF03403. PAF-AH_p_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79106-1 [UniParc]FASTAAdd to Basket

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    MGVNQSVSFP PVTGPHLVGC GDVMEGQSLQ GSFFRLFYPC QEAEETSEQP    50
    LWIPRYEYCA GLAEYLKFNK RWGGLLFNLG VGSCRLPVSW NGPFKTKDSG 100
    YPLIIFSHGM GAFRTVYSAF CMELASRGFV VAVPEHRDGS AAATCFCKQT 150
    PEENQPDNEA LKEEWIPHRQ IEEGEKEFYV RNYQVHQRVS ECVRVLKILQ 200
    EVTAGQAVLN ILPGGLDLMT LKGGIDVSRV AVMGHSFGGA TAILALAKEM 250
    QFRCAVALDA WMFPLEHDFY PTARGPIFFI NAEKFQTVET VNLMKKICDQ 300
    HHQSRIITVL GSVHRSLTDF VFVAGNWISK FFSSHTRGSL DPYEGQETVV 350
    RAMLAFLQKH LDLKEDYDQW NNFIEGIGPS LTPGAPHHLS SL 392
    Length:392
    Mass (Da):43,865
    Last modified:May 1, 1997 - v1
    Checksum:i1DEACA2ADFA4CEA8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87559 mRNA. Translation: BAA13419.1.
    BT020849 mRNA. Translation: AAX08866.1.
    BC105148 mRNA. Translation: AAI05149.1.
    RefSeqiNP_776995.1. NM_174570.2.
    UniGeneiBt.103232.
    Bt.4013.

    Genome annotation databases

    EnsembliENSBTAT00000006727; ENSBTAP00000006727; ENSBTAG00000005105.
    ENSBTAT00000065543; ENSBTAP00000056542; ENSBTAG00000005105.
    GeneIDi282299.
    KEGGibta:282299.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87559 mRNA. Translation: BAA13419.1 .
    BT020849 mRNA. Translation: AAX08866.1 .
    BC105148 mRNA. Translation: AAI05149.1 .
    RefSeqi NP_776995.1. NM_174570.2.
    UniGenei Bt.103232.
    Bt.4013.

    3D structure databases

    ProteinModelPortali P79106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000006727.

    Protocols and materials databases

    DNASUi 282299.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000006727 ; ENSBTAP00000006727 ; ENSBTAG00000005105 .
    ENSBTAT00000065543 ; ENSBTAP00000056542 ; ENSBTAG00000005105 .
    GeneIDi 282299.
    KEGGi bta:282299.

    Organism-specific databases

    CTDi 5051.

    Phylogenomic databases

    eggNOGi COG4188.
    GeneTreei ENSGT00390000005233.
    HOGENOMi HOG000008053.
    HOVERGENi HBG001322.
    InParanoidi P79106.
    KOi K01062.
    OMAi QFRCAVA.
    OrthoDBi EOG7MSMQ5.
    TreeFami TF313831.

    Miscellaneous databases

    NextBioi 20806100.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view ]
    PANTHERi PTHR10272. PTHR10272. 1 hit.
    Pfami PF03403. PAF-AH_p_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase."
      Hattori K., Adachi H., Matsuzawa A., Yamamoto K., Tsujimoto M., Aoki J., Hattori M., Arai H., Inoue K.
      J. Biol. Chem. 271:33032-33038(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    4. Cited for: REVIEW.

    Entry informationi

    Entry nameiPAFA2_BOVIN
    AccessioniPrimary (citable) accession number: P79106
    Secondary accession number(s): Q5E9S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3