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P79106

- PAFA2_BOVIN

UniProt

P79106 - PAFA2_BOVIN

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Protein

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Gene

PAFAH2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei236 – 2361NucleophileBy similarity
Active sitei259 – 2591Charge relay systemPROSITE-ProRule annotation
Active sitei314 – 3141Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

  1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC:3.1.1.47)
Alternative name(s):
Serine-dependent phospholipase A2
Short name:
SD-PLA2
Gene namesi
Name:PAFAH2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Platelet-activating factor acetylhydrolase 2, cytoplasmicPRO_0000090382Add
BLAST

Expressioni

Tissue specificityi

Expressed at highest levels in liver and at lower levels in other tissues.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006727.

Structurei

3D structure databases

ProteinModelPortaliP79106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Phylogenomic databases

eggNOGiCOG4188.
GeneTreeiENSGT00390000005233.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiP79106.
KOiK01062.
OMAiQFRCAVA.
OrthoDBiEOG7MSMQ5.
TreeFamiTF313831.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79106-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGVNQSVSFP PVTGPHLVGC GDVMEGQSLQ GSFFRLFYPC QEAEETSEQP
60 70 80 90 100
LWIPRYEYCA GLAEYLKFNK RWGGLLFNLG VGSCRLPVSW NGPFKTKDSG
110 120 130 140 150
YPLIIFSHGM GAFRTVYSAF CMELASRGFV VAVPEHRDGS AAATCFCKQT
160 170 180 190 200
PEENQPDNEA LKEEWIPHRQ IEEGEKEFYV RNYQVHQRVS ECVRVLKILQ
210 220 230 240 250
EVTAGQAVLN ILPGGLDLMT LKGGIDVSRV AVMGHSFGGA TAILALAKEM
260 270 280 290 300
QFRCAVALDA WMFPLEHDFY PTARGPIFFI NAEKFQTVET VNLMKKICDQ
310 320 330 340 350
HHQSRIITVL GSVHRSLTDF VFVAGNWISK FFSSHTRGSL DPYEGQETVV
360 370 380 390
RAMLAFLQKH LDLKEDYDQW NNFIEGIGPS LTPGAPHHLS SL
Length:392
Mass (Da):43,865
Last modified:May 1, 1997 - v1
Checksum:i1DEACA2ADFA4CEA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87559 mRNA. Translation: BAA13419.1.
BT020849 mRNA. Translation: AAX08866.1.
BC105148 mRNA. Translation: AAI05149.1.
RefSeqiNP_776995.1. NM_174570.2.
UniGeneiBt.103232.
Bt.4013.

Genome annotation databases

EnsembliENSBTAT00000006727; ENSBTAP00000006727; ENSBTAG00000005105.
ENSBTAT00000065543; ENSBTAP00000056542; ENSBTAG00000005105.
GeneIDi282299.
KEGGibta:282299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87559 mRNA. Translation: BAA13419.1 .
BT020849 mRNA. Translation: AAX08866.1 .
BC105148 mRNA. Translation: AAI05149.1 .
RefSeqi NP_776995.1. NM_174570.2.
UniGenei Bt.103232.
Bt.4013.

3D structure databases

ProteinModelPortali P79106.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000006727.

Protocols and materials databases

DNASUi 282299.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000006727 ; ENSBTAP00000006727 ; ENSBTAG00000005105 .
ENSBTAT00000065543 ; ENSBTAP00000056542 ; ENSBTAG00000005105 .
GeneIDi 282299.
KEGGi bta:282299.

Organism-specific databases

CTDi 5051.

Phylogenomic databases

eggNOGi COG4188.
GeneTreei ENSGT00390000005233.
HOGENOMi HOG000008053.
HOVERGENi HBG001322.
InParanoidi P79106.
KOi K01062.
OMAi QFRCAVA.
OrthoDBi EOG7MSMQ5.
TreeFami TF313831.

Miscellaneous databases

NextBioi 20806100.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view ]
PANTHERi PTHR10272. PTHR10272. 1 hit.
Pfami PF03403. PAF-AH_p_II. 1 hit.
[Graphical view ]
PIRSFi PIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMi SSF53474. SSF53474. 2 hits.
PROSITEi PS00120. LIPASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase."
    Hattori K., Adachi H., Matsuzawa A., Yamamoto K., Tsujimoto M., Aoki J., Hattori M., Arai H., Inoue K.
    J. Biol. Chem. 271:33032-33038(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  4. Cited for: REVIEW.

Entry informationi

Entry nameiPAFA2_BOVIN
AccessioniPrimary (citable) accession number: P79106
Secondary accession number(s): Q5E9S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3