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P79106 (PAFA2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic

EC=3.1.1.47
Alternative name(s):
Serine-dependent phospholipase A2
Short name=SD-PLA2
Gene names
Name:PAFAH2
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.

Catalytic activity

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Subunit structure

Monomer.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed at highest levels in liver and at lower levels in other tissues.

Sequence similarities

Belongs to the serine esterase family.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Platelet-activating factor acetylhydrolase 2, cytoplasmic
PRO_0000090382

Sites

Active site2361Nucleophile By similarity
Active site2591Charge relay system By similarity
Active site3141Charge relay system By similarity

Sequences

Sequence LengthMass (Da)Tools
P79106 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 1DEACA2ADFA4CEA8

FASTA39243,865
        10         20         30         40         50         60 
MGVNQSVSFP PVTGPHLVGC GDVMEGQSLQ GSFFRLFYPC QEAEETSEQP LWIPRYEYCA 

        70         80         90        100        110        120 
GLAEYLKFNK RWGGLLFNLG VGSCRLPVSW NGPFKTKDSG YPLIIFSHGM GAFRTVYSAF 

       130        140        150        160        170        180 
CMELASRGFV VAVPEHRDGS AAATCFCKQT PEENQPDNEA LKEEWIPHRQ IEEGEKEFYV 

       190        200        210        220        230        240 
RNYQVHQRVS ECVRVLKILQ EVTAGQAVLN ILPGGLDLMT LKGGIDVSRV AVMGHSFGGA 

       250        260        270        280        290        300 
TAILALAKEM QFRCAVALDA WMFPLEHDFY PTARGPIFFI NAEKFQTVET VNLMKKICDQ 

       310        320        330        340        350        360 
HHQSRIITVL GSVHRSLTDF VFVAGNWISK FFSSHTRGSL DPYEGQETVV RAMLAFLQKH 

       370        380        390 
LDLKEDYDQW NNFIEGIGPS LTPGAPHHLS SL 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase."
Hattori K., Adachi H., Matsuzawa A., Yamamoto K., Tsujimoto M., Aoki J., Hattori M., Arai H., Inoue K.
J. Biol. Chem. 271:33032-33038(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Kidney.
[2]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Ileum.
[4]"Platelet-activating factor acetylhydrolases."
Stafforini D.M., McIntyre T.M., Zimmerman G.A., Prescott S.M.
J. Biol. Chem. 272:17895-17898(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87559 mRNA. Translation: BAA13419.1.
BT020849 mRNA. Translation: AAX08866.1.
BC105148 mRNA. Translation: AAI05149.1.
RefSeqNP_776995.1. NM_174570.2.
UniGeneBt.103232.
Bt.4013.

3D structure databases

ProteinModelPortalP79106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000006727.

Protocols and materials databases

DNASU282299.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000006727; ENSBTAP00000006727; ENSBTAG00000005105.
ENSBTAT00000065543; ENSBTAP00000056542; ENSBTAG00000005105.
GeneID282299.
KEGGbta:282299.

Organism-specific databases

CTD5051.

Phylogenomic databases

eggNOGCOG4188.
GeneTreeENSGT00390000005233.
HOGENOMHOG000008053.
HOVERGENHBG001322.
InParanoidP79106.
KOK01062.
OMAQFRCAVA.
OrthoDBEOG7MSMQ5.
TreeFamTF313831.

Family and domain databases

InterProIPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERPTHR10272. PTHR10272. 1 hit.
PfamPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFPIRSF018169. PAF_acetylhydrolase. 1 hit.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806100.

Entry information

Entry namePAFA2_BOVIN
AccessionPrimary (citable) accession number: P79106
Secondary accession number(s): Q5E9S1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: February 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families