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P79102

- CP3AS_BOVIN

UniProt

P79102 - CP3AS_BOVIN

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Protein

Cytochrome P450 3A28

Gene

CYP3A28

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A28 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA28
Gene namesi
Name:CYP3A28
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Cytochrome P450 3A28PRO_0000051807Add
BLAST

Proteomic databases

PRIDEiP79102.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliP79102.
SMRiP79102. Positions 30-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG108567.
InParanoidiP79102.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79102-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELIPSFSME TWVLLATSLV LLYIYGTYSY GLFKKLGIPG PRPVPYFGST
60 70 80 90 100
MAYHKGIPEF DNQCFKKYGK MWGFYEGRQP MLAITDPDII KTVLVKECYS
110 120 130 140 150
VFTNRRIFGP MGIMKYAISL AWDEQWKRIR TLLSPAFTSG KLKEMFPIIG
160 170 180 190 200
QYGDMLVRNL RKEAEKGNPV NMKDMFGAYS MDVITGTAFG VNIDSLNNPH
210 220 230 240 250
DPFVEHSKNL LRFRPFDPFI LSIILFPFLN PVFEILNITL FPKSTVDFFT
260 270 280 290 300
KSVKKIKESR LTDKQMNRVD LLQLMINSQN SKEIDNHKAL SDIELVAQST
310 320 330 340 350
IFIFGGYETT SSTLSFIIYE LTTHPHVQQK LQEEIDATFP NKAPPTYDAL
360 370 380 390 400
VQMEYLDMVV NETLRMFPIA GRLERVCKKD VEIHGVTIPK GTTVLVPLFV
410 420 430 440 450
LHNNPELWPE PEEFRPERFS KNNKDSINPY VYLPFGTGPR NCLGMRFAIM
460 470 480 490 500
NIKLALVRIL QNFSFKPCKE TQIPLKLYTQ GLTQPEQPVI LKVVPRGLGP

QVEPDFL
Length:507
Mass (Da):58,152
Last modified:May 1, 1997 - v1
Checksum:iFDFD8465CC96DF57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10214 mRNA. Translation: CAA71266.1.
UniGeneiBt.82.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10214 mRNA. Translation: CAA71266.1 .
UniGenei Bt.82.

3D structure databases

ProteinModelPortali P79102.
SMRi P79102. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P79102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG2124.
HOVERGENi HBG108567.
InParanoidi P79102.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells."
    Natsuhori M., van Raak M., Ligtenberg M., Kleij L., ten Berge D., Zweers-Zeilmaker W.M., de Groene E.M., van Miert A.S.J.P.A., Witkamp R.F., Horbach G.J.M.J.
    Environ. Toxicol. Pharmacol. 3:17-24(1997)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hereford.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AS_BOVIN
AccessioniPrimary (citable) accession number: P79102
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3