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P79102

- CP3AS_BOVIN

UniProt

P79102 - CP3AS_BOVIN

Protein

Cytochrome P450 3A28

Gene

CYP3A28

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A28 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA28
    Gene namesi
    Name:CYP3A28
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Cytochrome P450 3A28PRO_0000051807Add
    BLAST

    Proteomic databases

    PRIDEiP79102.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliP79102.
    SMRiP79102. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOVERGENiHBG108567.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P79102-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELIPSFSME TWVLLATSLV LLYIYGTYSY GLFKKLGIPG PRPVPYFGST    50
    MAYHKGIPEF DNQCFKKYGK MWGFYEGRQP MLAITDPDII KTVLVKECYS 100
    VFTNRRIFGP MGIMKYAISL AWDEQWKRIR TLLSPAFTSG KLKEMFPIIG 150
    QYGDMLVRNL RKEAEKGNPV NMKDMFGAYS MDVITGTAFG VNIDSLNNPH 200
    DPFVEHSKNL LRFRPFDPFI LSIILFPFLN PVFEILNITL FPKSTVDFFT 250
    KSVKKIKESR LTDKQMNRVD LLQLMINSQN SKEIDNHKAL SDIELVAQST 300
    IFIFGGYETT SSTLSFIIYE LTTHPHVQQK LQEEIDATFP NKAPPTYDAL 350
    VQMEYLDMVV NETLRMFPIA GRLERVCKKD VEIHGVTIPK GTTVLVPLFV 400
    LHNNPELWPE PEEFRPERFS KNNKDSINPY VYLPFGTGPR NCLGMRFAIM 450
    NIKLALVRIL QNFSFKPCKE TQIPLKLYTQ GLTQPEQPVI LKVVPRGLGP 500
    QVEPDFL 507
    Length:507
    Mass (Da):58,152
    Last modified:May 1, 1997 - v1
    Checksum:iFDFD8465CC96DF57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10214 mRNA. Translation: CAA71266.1.
    UniGeneiBt.82.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10214 mRNA. Translation: CAA71266.1 .
    UniGenei Bt.82.

    3D structure databases

    ProteinModelPortali P79102.
    SMRi P79102. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P79102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOVERGENi HBG108567.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells."
      Natsuhori M., van Raak M., Ligtenberg M., Kleij L., ten Berge D., Zweers-Zeilmaker W.M., de Groene E.M., van Miert A.S.J.P.A., Witkamp R.F., Horbach G.J.M.J.
      Environ. Toxicol. Pharmacol. 3:17-24(1997)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hereford.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AS_BOVIN
    AccessioniPrimary (citable) accession number: P79102
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3