Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P79102 (CP3AS_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A28

EC=1.14.14.1
Alternative name(s):
CYPIIIA28
Gene names
Name:CYP3A28
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Cytochrome P450 3A28
PRO_0000051807

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P79102 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: FDFD8465CC96DF57

FASTA50758,152
        10         20         30         40         50         60 
MELIPSFSME TWVLLATSLV LLYIYGTYSY GLFKKLGIPG PRPVPYFGST MAYHKGIPEF 

        70         80         90        100        110        120 
DNQCFKKYGK MWGFYEGRQP MLAITDPDII KTVLVKECYS VFTNRRIFGP MGIMKYAISL 

       130        140        150        160        170        180 
AWDEQWKRIR TLLSPAFTSG KLKEMFPIIG QYGDMLVRNL RKEAEKGNPV NMKDMFGAYS 

       190        200        210        220        230        240 
MDVITGTAFG VNIDSLNNPH DPFVEHSKNL LRFRPFDPFI LSIILFPFLN PVFEILNITL 

       250        260        270        280        290        300 
FPKSTVDFFT KSVKKIKESR LTDKQMNRVD LLQLMINSQN SKEIDNHKAL SDIELVAQST 

       310        320        330        340        350        360 
IFIFGGYETT SSTLSFIIYE LTTHPHVQQK LQEEIDATFP NKAPPTYDAL VQMEYLDMVV 

       370        380        390        400        410        420 
NETLRMFPIA GRLERVCKKD VEIHGVTIPK GTTVLVPLFV LHNNPELWPE PEEFRPERFS 

       430        440        450        460        470        480 
KNNKDSINPY VYLPFGTGPR NCLGMRFAIM NIKLALVRIL QNFSFKPCKE TQIPLKLYTQ 

       490        500 
GLTQPEQPVI LKVVPRGLGP QVEPDFL 

« Hide

References

[1]"Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells."
Natsuhori M., van Raak M., Ligtenberg M., Kleij L., ten Berge D., Zweers-Zeilmaker W.M., de Groene E.M., van Miert A.S.J.P.A., Witkamp R.F., Horbach G.J.M.J.
Environ. Toxicol. Pharmacol. 3:17-24(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hereford.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y10214 mRNA. Translation: CAA71266.1.
UniGeneBt.82.

3D structure databases

ProteinModelPortalP79102.
SMRP79102. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP79102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG2124.
HOVERGENHBG108567.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AS_BOVIN
AccessionPrimary (citable) accession number: P79102
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: January 22, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families