Skip Header

Contribute Send feedback
Read comments (?) or add your own

P79089 (IDHP_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP], mitochondrial
Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icdA
OrganismAspergillus niger
Taxonomic identifier5061 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion
Chain? – 498Isocitrate dehydrogenase [NADP], mitochondrialPRO_0000014423

Regions

Nucleotide binding164 – 1663NADP By similarity
Nucleotide binding397 – 4026NADP By similarity
Region183 – 1897Substrate binding By similarity

Sites

Metal binding3391Magnesium or manganese By similarity
Metal binding3621Magnesium or manganese By similarity
Binding site1661Substrate By similarity
Binding site1711NADP By similarity
Binding site1981Substrate By similarity
Binding site2211Substrate By similarity
Binding site3471NADP By similarity
Binding site4151NADP; via amide nitrogen and carbonyl oxygen By similarity
Site2281Critical for catalysis By similarity
Site2991Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P79089 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: 60FAB99B0A315CF0

FASTA49855,559
        10         20         30         40         50         60 
MSSVRFSSAL ARRSFAVASP PLSAPLSSSA RRFLSSSSST ISSSSSSVST RSPRSLTSAS 

        70         80         90        100        110        120 
SLLSSRTASA RWTGLSSLNL TQSRTMATEI PKIKVKNPVV ELDGDEMTRI IWQEIREKLI 

       130        140        150        160        170        180 
LPYLDVDLKY YDLGLEYRDQ TDDQVTVEAA EAIKKYGVGV KCATITPDEA RVEEFKLKKM 

       190        200        210        220        230        240 
WLSPNGTIRN ILGGTVFREP IIIPAIPRLV PGWNKPIIIG RHAFGDQYRA TDRVIPGPGK 

       250        260        270        280        290        300 
LELVYTPVNG EPETVKVYDF QGGGIAQTQY NTDESIRGFA HASFQMALLK GLPLYMSTKN 

       310        320        330        340        350        360 
TILKRYDGRF KDIFQEIYES TYQKDFEAKN LWYEHRLIDD MVAQMIKSEG GFVMALKNYD 

       370        380        390        400        410        420 
GDVQSDIVAQ GFGSLGLMTS TLVTPTGEAF ESEAAHGTVT RHYREHQKGR ETSTNPIASI 

       430        440        450        460        470        480 
FAWTRGLIQR GKLDETPDVV TFAEELERAC IEVVNDEGIM TKDLALACGR KEREAWVTTR 

       490 
EYMAAVERRL KANLKSRL

« Hide

References

[1]"Cloning and expression of Aspergillus niger icdA gene encoding mitochondrial NADP+-specific isocitrate dehydrogenase."
Kirimura K., Yoda M., Kumagai M., Ishii Y., Kino K., Usami S.
J. Biosci. Bioeng. 93:136-144(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: WU-2223L.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB000262 Genomic DNA. Translation: BAA19074.1.
AB000261 mRNA. Translation: BAA19073.1.

3D structure databases

ProteinModelPortalP79089.
SMRP79089. Positions 92-496.
ModBaseSearch...

Proteomic databases

PRIDEP79089.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0538.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDHP_ASPNG
AccessionPrimary (citable) accession number: P79089
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents