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P79089

- IDHP_ASPNG

UniProt

P79089 - IDHP_ASPNG

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Protein

Isocitrate dehydrogenase [NADP], mitochondrial

Gene
icdA
Organism
Aspergillus niger
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei166 – 1661Substrate By similarity
Binding sitei171 – 1711NADP By similarity
Binding sitei198 – 1981Substrate By similarity
Binding sitei221 – 2211Substrate By similarity
Sitei228 – 2281Critical for catalysis By similarity
Sitei299 – 2991Critical for catalysis By similarity
Metal bindingi339 – 3391Magnesium or manganese By similarity
Binding sitei347 – 3471NADP By similarity
Metal bindingi362 – 3621Magnesium or manganese By similarity
Binding sitei415 – 4151NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi164 – 1663NADP By similarity
Nucleotide bindingi397 – 4026NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. isocitrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icdA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 498Isocitrate dehydrogenase [NADP], mitochondrialPRO_0000014423
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PRIDEiP79089.

Structurei

3D structure databases

ProteinModelPortaliP79089.
SMRiP79089. Positions 92-496.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni183 – 1897Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0538.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79089-1 [UniParc]FASTAAdd to Basket

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MSSVRFSSAL ARRSFAVASP PLSAPLSSSA RRFLSSSSST ISSSSSSVST    50
RSPRSLTSAS SLLSSRTASA RWTGLSSLNL TQSRTMATEI PKIKVKNPVV 100
ELDGDEMTRI IWQEIREKLI LPYLDVDLKY YDLGLEYRDQ TDDQVTVEAA 150
EAIKKYGVGV KCATITPDEA RVEEFKLKKM WLSPNGTIRN ILGGTVFREP 200
IIIPAIPRLV PGWNKPIIIG RHAFGDQYRA TDRVIPGPGK LELVYTPVNG 250
EPETVKVYDF QGGGIAQTQY NTDESIRGFA HASFQMALLK GLPLYMSTKN 300
TILKRYDGRF KDIFQEIYES TYQKDFEAKN LWYEHRLIDD MVAQMIKSEG 350
GFVMALKNYD GDVQSDIVAQ GFGSLGLMTS TLVTPTGEAF ESEAAHGTVT 400
RHYREHQKGR ETSTNPIASI FAWTRGLIQR GKLDETPDVV TFAEELERAC 450
IEVVNDEGIM TKDLALACGR KEREAWVTTR EYMAAVERRL KANLKSRL 498
Length:498
Mass (Da):55,559
Last modified:May 1, 1997 - v1
Checksum:i60FAB99B0A315CF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000262 Genomic DNA. Translation: BAA19074.1.
AB000261 mRNA. Translation: BAA19073.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB000262 Genomic DNA. Translation: BAA19074.1 .
AB000261 mRNA. Translation: BAA19073.1 .

3D structure databases

ProteinModelPortali P79089.
SMRi P79089. Positions 92-496.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P79089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0538.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of Aspergillus niger icdA gene encoding mitochondrial NADP+-specific isocitrate dehydrogenase."
    Kirimura K., Yoda M., Kumagai M., Ishii Y., Kino K., Usami S.
    J. Biosci. Bioeng. 93:136-144(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: WU-2223L.

Entry informationi

Entry nameiIDHP_ASPNG
AccessioniPrimary (citable) accession number: P79089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 13, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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