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P79089

- IDHP_ASPNG

UniProt

P79089 - IDHP_ASPNG

Protein

Isocitrate dehydrogenase [NADP], mitochondrial

Gene

icdA

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei166 – 1661SubstrateBy similarity
    Binding sitei171 – 1711NADPBy similarity
    Binding sitei198 – 1981SubstrateBy similarity
    Binding sitei221 – 2211SubstrateBy similarity
    Sitei228 – 2281Critical for catalysisBy similarity
    Sitei299 – 2991Critical for catalysisBy similarity
    Metal bindingi339 – 3391Magnesium or manganeseBy similarity
    Binding sitei347 – 3471NADPBy similarity
    Metal bindingi362 – 3621Magnesium or manganeseBy similarity
    Binding sitei415 – 4151NADP; via amide nitrogen and carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi164 – 1663NADPBy similarity
    Nucleotide bindingi397 – 4026NADPBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. isocitrate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icdA
    OrganismiAspergillus niger
    Taxonomic identifieri5061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 498Isocitrate dehydrogenase [NADP], mitochondrialPRO_0000014423
    Transit peptidei1 – ?Mitochondrion

    Proteomic databases

    PRIDEiP79089.

    Structurei

    3D structure databases

    ProteinModelPortaliP79089.
    SMRiP79089. Positions 92-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni183 – 1897Substrate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0538.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P79089-1 [UniParc]FASTAAdd to Basket

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    MSSVRFSSAL ARRSFAVASP PLSAPLSSSA RRFLSSSSST ISSSSSSVST    50
    RSPRSLTSAS SLLSSRTASA RWTGLSSLNL TQSRTMATEI PKIKVKNPVV 100
    ELDGDEMTRI IWQEIREKLI LPYLDVDLKY YDLGLEYRDQ TDDQVTVEAA 150
    EAIKKYGVGV KCATITPDEA RVEEFKLKKM WLSPNGTIRN ILGGTVFREP 200
    IIIPAIPRLV PGWNKPIIIG RHAFGDQYRA TDRVIPGPGK LELVYTPVNG 250
    EPETVKVYDF QGGGIAQTQY NTDESIRGFA HASFQMALLK GLPLYMSTKN 300
    TILKRYDGRF KDIFQEIYES TYQKDFEAKN LWYEHRLIDD MVAQMIKSEG 350
    GFVMALKNYD GDVQSDIVAQ GFGSLGLMTS TLVTPTGEAF ESEAAHGTVT 400
    RHYREHQKGR ETSTNPIASI FAWTRGLIQR GKLDETPDVV TFAEELERAC 450
    IEVVNDEGIM TKDLALACGR KEREAWVTTR EYMAAVERRL KANLKSRL 498
    Length:498
    Mass (Da):55,559
    Last modified:May 1, 1997 - v1
    Checksum:i60FAB99B0A315CF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000262 Genomic DNA. Translation: BAA19074.1.
    AB000261 mRNA. Translation: BAA19073.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000262 Genomic DNA. Translation: BAA19074.1 .
    AB000261 mRNA. Translation: BAA19073.1 .

    3D structure databases

    ProteinModelPortali P79089.
    SMRi P79089. Positions 92-496.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P79089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0538.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of Aspergillus niger icdA gene encoding mitochondrial NADP+-specific isocitrate dehydrogenase."
      Kirimura K., Yoda M., Kumagai M., Ishii Y., Kino K., Usami S.
      J. Biosci. Bioeng. 93:136-144(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: WU-2223L.

    Entry informationi

    Entry nameiIDHP_ASPNG
    AccessioniPrimary (citable) accession number: P79089
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3