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Protein

Isocitrate dehydrogenase [NADP], mitochondrial

Gene

icdA

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166SubstrateBy similarity1
Binding sitei171NADPBy similarity1
Binding sitei198SubstrateBy similarity1
Binding sitei221SubstrateBy similarity1
Sitei228Critical for catalysisBy similarity1
Sitei299Critical for catalysisBy similarity1
Metal bindingi339Magnesium or manganeseBy similarity1
Binding sitei347NADPBy similarity1
Metal bindingi362Magnesium or manganeseBy similarity1
Binding sitei415NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi164 – 166NADPBy similarity3
Nucleotide bindingi397 – 402NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icdA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000014423? – 498Isocitrate dehydrogenase [NADP], mitochondrial
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PaxDbiP79089.
PRIDEiP79089.

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00002693.

Structurei

3D structure databases

ProteinModelPortaliP79089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 189Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVRFSSAL ARRSFAVASP PLSAPLSSSA RRFLSSSSST ISSSSSSVST
60 70 80 90 100
RSPRSLTSAS SLLSSRTASA RWTGLSSLNL TQSRTMATEI PKIKVKNPVV
110 120 130 140 150
ELDGDEMTRI IWQEIREKLI LPYLDVDLKY YDLGLEYRDQ TDDQVTVEAA
160 170 180 190 200
EAIKKYGVGV KCATITPDEA RVEEFKLKKM WLSPNGTIRN ILGGTVFREP
210 220 230 240 250
IIIPAIPRLV PGWNKPIIIG RHAFGDQYRA TDRVIPGPGK LELVYTPVNG
260 270 280 290 300
EPETVKVYDF QGGGIAQTQY NTDESIRGFA HASFQMALLK GLPLYMSTKN
310 320 330 340 350
TILKRYDGRF KDIFQEIYES TYQKDFEAKN LWYEHRLIDD MVAQMIKSEG
360 370 380 390 400
GFVMALKNYD GDVQSDIVAQ GFGSLGLMTS TLVTPTGEAF ESEAAHGTVT
410 420 430 440 450
RHYREHQKGR ETSTNPIASI FAWTRGLIQR GKLDETPDVV TFAEELERAC
460 470 480 490
IEVVNDEGIM TKDLALACGR KEREAWVTTR EYMAAVERRL KANLKSRL
Length:498
Mass (Da):55,559
Last modified:May 1, 1997 - v1
Checksum:i60FAB99B0A315CF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000262 Genomic DNA. Translation: BAA19074.1.
AB000261 mRNA. Translation: BAA19073.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000262 Genomic DNA. Translation: BAA19074.1.
AB000261 mRNA. Translation: BAA19073.1.

3D structure databases

ProteinModelPortaliP79089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00002693.

Proteomic databases

PaxDbiP79089.
PRIDEiP79089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDHP_ASPNG
AccessioniPrimary (citable) accession number: P79089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.