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P79089

- IDHP_ASPNG

UniProt

P79089 - IDHP_ASPNG

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Protein

Isocitrate dehydrogenase [NADP], mitochondrial

Gene

icdA

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei166 – 1661SubstrateBy similarity
Binding sitei171 – 1711NADPBy similarity
Binding sitei198 – 1981SubstrateBy similarity
Binding sitei221 – 2211SubstrateBy similarity
Sitei228 – 2281Critical for catalysisBy similarity
Sitei299 – 2991Critical for catalysisBy similarity
Metal bindingi339 – 3391Magnesium or manganeseBy similarity
Binding sitei347 – 3471NADPBy similarity
Metal bindingi362 – 3621Magnesium or manganeseBy similarity
Binding sitei415 – 4151NADP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi164 – 1663NADPBy similarity
Nucleotide bindingi397 – 4026NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. isocitrate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icdA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 498Isocitrate dehydrogenase [NADP], mitochondrialPRO_0000014423
Transit peptidei1 – ?Mitochondrion

Proteomic databases

PRIDEiP79089.

Structurei

3D structure databases

ProteinModelPortaliP79089.
SMRiP79089. Positions 92-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni183 – 1897Substrate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0538.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSVRFSSAL ARRSFAVASP PLSAPLSSSA RRFLSSSSST ISSSSSSVST
60 70 80 90 100
RSPRSLTSAS SLLSSRTASA RWTGLSSLNL TQSRTMATEI PKIKVKNPVV
110 120 130 140 150
ELDGDEMTRI IWQEIREKLI LPYLDVDLKY YDLGLEYRDQ TDDQVTVEAA
160 170 180 190 200
EAIKKYGVGV KCATITPDEA RVEEFKLKKM WLSPNGTIRN ILGGTVFREP
210 220 230 240 250
IIIPAIPRLV PGWNKPIIIG RHAFGDQYRA TDRVIPGPGK LELVYTPVNG
260 270 280 290 300
EPETVKVYDF QGGGIAQTQY NTDESIRGFA HASFQMALLK GLPLYMSTKN
310 320 330 340 350
TILKRYDGRF KDIFQEIYES TYQKDFEAKN LWYEHRLIDD MVAQMIKSEG
360 370 380 390 400
GFVMALKNYD GDVQSDIVAQ GFGSLGLMTS TLVTPTGEAF ESEAAHGTVT
410 420 430 440 450
RHYREHQKGR ETSTNPIASI FAWTRGLIQR GKLDETPDVV TFAEELERAC
460 470 480 490
IEVVNDEGIM TKDLALACGR KEREAWVTTR EYMAAVERRL KANLKSRL
Length:498
Mass (Da):55,559
Last modified:May 1, 1997 - v1
Checksum:i60FAB99B0A315CF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000262 Genomic DNA. Translation: BAA19074.1.
AB000261 mRNA. Translation: BAA19073.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000262 Genomic DNA. Translation: BAA19074.1 .
AB000261 mRNA. Translation: BAA19073.1 .

3D structure databases

ProteinModelPortali P79089.
SMRi P79089. Positions 92-496.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P79089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0538.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of Aspergillus niger icdA gene encoding mitochondrial NADP+-specific isocitrate dehydrogenase."
    Kirimura K., Yoda M., Kumagai M., Ishii Y., Kino K., Usami S.
    J. Biosci. Bioeng. 93:136-144(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: WU-2223L.

Entry informationi

Entry nameiIDHP_ASPNG
AccessioniPrimary (citable) accession number: P79089
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3