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Protein

Protein transport protein sec61 subunit alpha

Gene

sec61

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to sec62/63 complex, secretory precursor polypeptides may engage sec61 to begin membrane penetration event. A cycle of assembly and disassembly of sec62/63 from sec61 may govern the activity of the translocase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-SPO-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein sec61 subunit alpha
Gene namesi
Name:sec61
ORF Names:SPBC354.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC354.02c.
PomBaseiSPBC354.02c. sec61.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434CytoplasmicSequence analysisAdd
BLAST
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Topological domaini56 – 7621LumenalSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Topological domaini98 – 11922CytoplasmicSequence analysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence analysisAdd
BLAST
Topological domaini141 – 1466LumenalSequence analysis
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Topological domaini168 – 24578CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 35488LumenalSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 41540CytoplasmicSequence analysisAdd
BLAST
Transmembranei416 – 43419HelicalSequence analysisAdd
BLAST
Topological domaini435 – 4406LumenalSequence analysis
Transmembranei441 – 45818HelicalSequence analysisAdd
BLAST
Topological domaini459 – 47921CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: PomBase
  • Golgi apparatus Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
  • Sec61 translocon complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Protein transport protein sec61 subunit alphaPRO_0000131787Add
BLAST

Proteomic databases

MaxQBiP79088.

PTM databases

SwissPalmiP79088.

Interactioni

Subunit structurei

Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.By similarity

Protein-protein interaction databases

BioGridi277552. 1 interaction.
MINTiMINT-4692087.

Structurei

3D structure databases

ProteinModelPortaliP79088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231249.
InParanoidiP79088.
KOiK10956.
OMAiRYIPYVT.
OrthoDBiEOG7VHT6B.
PhylomeDBiP79088.

Family and domain databases

Gene3Di1.10.3370.10. 2 hits.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 2 hits.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLRFLDLV KPFAPFLPEI AAPERKVPFK QKMLWTGVTL LIFLVMSQVP
60 70 80 90 100
LYGIVSSDSS DPLLWLRMIL AANRGTLMEL GISPIVTSSM LVQLLVGSQL
110 120 130 140 150
IEVNMELKSD REMYQLVQKF LAIIIAFGQA TAYVLTGMYG RPQDLGAGIC
160 170 180 190 200
LLLILQLAAA SLIVLLLDEL LQKGYGLGSG ISLFIATINC ENIFWKAFSP
210 220 230 240 250
TTYHIANGVQ FEGAVINFVY VMFTWDNKAA ALYQAFFRSG LTSSQIQLPN
260 270 280 290 300
LWNFFATLLV FGVVIYLQDF RVEIPIRSQK FRGYRSTFPV KLLYTSNTPI
310 320 330 340 350
MLQSALTSNL FFASRLLFNR FSSNFLVRFL GVWEQTATSG LSYYLSPPAS
360 370 380 390 400
FQDALIDPIH TLVYVFFTMF ACALFSKLWI EVSGASPRDV AKQLKSQQLV
410 420 430 440 450
MAGHREGSMY KELKRIIPTA AWLSGAVVGA LAVASDLLGA LGSGTAVLLC
460 470
TTTIYGYYEQ LQKEIKGDQY GLPVTPMMQ
Length:479
Mass (Da):53,254
Last modified:May 1, 1997 - v1
Checksum:i36E3F08E2CFD9868
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11376 mRNA. Translation: CAA72200.1.
Y11375 Genomic DNA. Translation: CAA72199.1.
CU329671 Genomic DNA. Translation: CAA17802.1.
AB027782 Genomic DNA. Translation: BAA87086.1.
PIRiT40282.
RefSeqiNP_595226.1. NM_001021132.2.

Genome annotation databases

EnsemblFungiiSPBC354.02c.1; SPBC354.02c.1:pep; SPBC354.02c.
GeneIDi2541037.
KEGGispo:SPBC354.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11376 mRNA. Translation: CAA72200.1.
Y11375 Genomic DNA. Translation: CAA72199.1.
CU329671 Genomic DNA. Translation: CAA17802.1.
AB027782 Genomic DNA. Translation: BAA87086.1.
PIRiT40282.
RefSeqiNP_595226.1. NM_001021132.2.

3D structure databases

ProteinModelPortaliP79088.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277552. 1 interaction.
MINTiMINT-4692087.

PTM databases

SwissPalmiP79088.

Proteomic databases

MaxQBiP79088.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC354.02c.1; SPBC354.02c.1:pep; SPBC354.02c.
GeneIDi2541037.
KEGGispo:SPBC354.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC354.02c.
PomBaseiSPBC354.02c. sec61.

Phylogenomic databases

HOGENOMiHOG000231249.
InParanoidiP79088.
KOiK10956.
OMAiRYIPYVT.
OrthoDBiEOG7VHT6B.
PhylomeDBiP79088.

Enzyme and pathway databases

ReactomeiR-SPO-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi20802151.
PROiP79088.

Family and domain databases

Gene3Di1.10.3370.10. 2 hits.
InterProiIPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
IPR019561. Translocon_Sec61/SecY_plug_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF10559. Plug_translocon. 1 hit.
PF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 2 hits.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of SEC61 homologues from Schizosaccharomyces pombe and Yarrowia lipolytica reveals the extent of functional conservation within this core component of the ER translocation machinery."
    Broughton J., Swennen D., Wilkinson B.M., Joyet P., Gaillardin C., Stirling C.J.
    J. Cell Sci. 110:2715-2727(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 121-179, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.

Entry informationi

Entry nameiSC61A_SCHPO
AccessioniPrimary (citable) accession number: P79088
Secondary accession number(s): Q9UU67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: April 13, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.