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Protein

Major allergen Alt a 1

Gene

ALTA1

Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Alt a 1
Alternative name(s):
Allergen: Alt a 1
Gene namesi
Name:ALTA1
OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifieri5599 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei11. Alt a 1.0101.
722. Alt a 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 157139Major allergen Alt a 1PRO_0000020699Add
BLAST

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Binary interactionsi

WithEntry#Exp.IntActNotes
tlpP813703EBI-9212161,EBI-9212168From a different organism.

Protein-protein interaction databases

IntActiP79085. 3 interactions.

Structurei

Secondary structure

1
157
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 323Combined sources
Beta strandi39 – 4911Combined sources
Beta strandi52 – 543Combined sources
Beta strandi56 – 6712Combined sources
Beta strandi71 – 777Combined sources
Beta strandi87 – 926Combined sources
Beta strandi96 – 1005Combined sources
Helixi101 – 1033Combined sources
Beta strandi105 – 1117Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi117 – 1237Combined sources
Beta strandi126 – 1305Combined sources
Beta strandi132 – 1343Combined sources
Beta strandi138 – 1447Combined sources
Beta strandi146 – 1494Combined sources
Beta strandi151 – 1533Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V0RX-ray1.90A26-157[»]
4AUDX-ray2.67A/B29-157[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ALTA1 family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR032382. AltA1.
[Graphical view]
PfamiPF16541. AltA1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFTTIASLF AAAGLAAAAP LESRQDTASC PVTTEGDYVW KISEFYGRKP
60 70 80 90 100
EGTYYNSLGF NIKATNGGTL DFTCSAQADK LEDHKWYSCG ENSFMDFSFD
110 120 130 140 150
SDRSGLLLKQ KVSDDITYVA TATLPNYCRA GGNGPKDFVC QGVADAYITL

VTLPKSS
Length:157
Mass (Da):16,980
Last modified:May 1, 1997 - v1
Checksum:iAAC20D0819198246
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86752 mRNA. Translation: AAB47552.1.
U82633 mRNA. Translation: AAB40400.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86752 mRNA. Translation: AAB47552.1.
U82633 mRNA. Translation: AAB40400.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V0RX-ray1.90A26-157[»]
4AUDX-ray2.67A/B29-157[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP79085. 3 interactions.

Protein family/group databases

Allergomei11. Alt a 1.0101.
722. Alt a 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR032382. AltA1.
[Graphical view]
PfamiPF16541. AltA1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation and expression of a cDNA clone encoding an Alternaria alternata Alt a 1 subunit."
    De Vouge M.W., Thaker A.J., Curran I.H., Zhang L., Muradia G., Rode H., Vijay H.M.
    Int. Arch. Allergy Immunol. 111:385-395(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. Unger A.M., Lechenauer E., Simon B., Oberkofler H., Probst G., Achatz G., Breitenbach M.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 08-0203-Berlin.

Entry informationi

Entry nameiALTA1_ALTAL
AccessioniPrimary (citable) accession number: P79085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: May 1, 1997
Last modified: November 11, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.