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Protein

Acyl-CoA desaturase

Gene

Ole 1

Organism
Cutaneotrichosporon curvatus (Oleaginous yeast) (Cryptococcus curvatus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stearyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.UniRule annotation

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Expected to bind 2 Fe2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processElectron transportUniRule annotation, Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturaseUniRule annotation (EC:1.14.19.1UniRule annotation)
Gene namesi
Name:Ole 1Imported
OrganismiCutaneotrichosporon curvatus (Oleaginous yeast) (Cryptococcus curvatus)Imported
Taxonomic identifieri57679 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTrichosporonalesTrichosporonaceaeCutaneotrichosporon

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Transmembranei106 – 127HelicalSequence analysisAdd BLAST22
Transmembranei139 – 158HelicalSequence analysisAdd BLAST20
Transmembranei219 – 240HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliP79077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini367 – 449Cytochrome b5 heme-bindingInterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR009160. Acyl-CoA_deSatase_haem/ster-bd.
IPR015876. Acyl-CoA_DS.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR005804. FA_desaturase_dom.
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
PIRSFiPIRSF000345. OLE1. 1 hit.
PRINTSiPR00363. CYTOCHROMEB5.
PR00075. FACDDSATRASE.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P79077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASTATAPP ATAPAVANPT PAAASAAAAA PAATKDKAET IDPESEHFVV
60 70 80 90 100
SQNYVTRTVE NMTMLPPVTW SNLLQNIQWI SFTALTVPPA MAIYGLCTLE
110 120 130 140 150
LQRKTVIWAI VYYFMTGLGI TAGYHRLWAH RAYNASAPLQ YFLALCGAGS
160 170 180 190 200
VQGSIKWWSR GHRAHHRYTD TKLDPYSAHE GFWWAHVGWM LVKPRGKIGV
210 220 230 240 250
ADISDLSRNP VVKWQHNNYV MLMVLMGLVF PTLVAGLGWG DWKGGLLFAG
260 270 280 290 300
AARLVFVHHS TFCVNSLAHW LGETPFDNKH TPKDHFITAL VTVGEGYHNF
310 320 330 340 350
HHQFPMDFRN AIKWYQYDPT KWFIWTMSNV GLASHLKKFP DNEIKKGQYT
360 370 380 390 400
MKLQMLQEQS GSIQWPKHSN DLPVISWEDF QAEAKERSLV AIHGFIHDCS
410 420 430 440 450
SFLEDHPGGI HLIKKAIGTD ATTAFFGGVY DHSNAAHNLL AMMRVGILDG
460 470 480 490
GMEVESLKLE NLQRSMSVSS MESDAASSAS SVSVSSISPR WPH
Length:493
Mass (Da):54,718
Last modified:May 1, 1997 - v1
Checksum:i852620CC2CB32D1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10422 Genomic DNA. Translation: CAA71449.1.
PIRiS71634.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiP79077_CUTCU
AccessioniPrimary (citable) accession number: P79077
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: May 10, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)