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P79075 (PYRF_CYBFA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Uridine 5'-monophosphate synthase
Short name=UMP synthase
Gene names
Name:URA3
OrganismCyberlindnera fabianii (Yeast) (Hansenula fabianii)
Taxonomic identifier36022 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Sequence similarities

Belongs to the OMP decarboxylase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134662

Regions

Region60 – 623Substrate binding By similarity
Region92 – 10110Substrate binding By similarity

Sites

Active site941Proton donor By similarity
Binding site381Substrate By similarity
Binding site2181Substrate By similarity
Binding site2361Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P79075 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: A694E609AB061BDB

FASTA26528,986
        10         20         30         40         50         60 
MVTTLSYTQR AEAHPSPLAK RLFTVMEQKK SNLCASIDVK TTDEFLSLVD TLGPYICLVK 

        70         80         90        100        110        120 
THIDIIDDFS FEGTIVPLKK LAEKHNFLIF EDRKFADIGK TVKNQYASGV FKIAQWSDIT 

       130        140        150        160        170        180 
NAHGVTGAGI VKGLKEAAQE TTDEPRGLLM LAELSSKGSL ATGEYTKQTV DIAKTDKDFV 

       190        200        210        220        230        240 
IGFIAQRDMG GHDEGFDWLI MTPGVGLDDK GDGLGQQYRG VDEVVAGGSD IIIVGRGLFG 

       250        260 
KGRDPAVEGE RYRSAGWNAY LKRCQ 

« Hide

References

[1]"Transformation system for a wastewater treatment yeast, Hansenula fabianii J640: isolation of the orotidine-5'-phosphate decarboxylase gene (URA3) and uracil auxotrophic mutants."
Kato M., Iefuji H., Miyake K., Iimura Y.
Appl. Microbiol. Biotechnol. 48:621-625(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: J640.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB001561 Genomic DNA. Translation: BAA19409.1.

3D structure databases

ProteinModelPortalP79075.
SMRP79075. Positions 6-264.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_CYBFA
AccessionPrimary (citable) accession number: P79075
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways