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P79075

- PYRF_CYBFA

UniProt

P79075 - PYRF_CYBFA

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
URA3
Organism
Cyberlindnera fabianii (Yeast) (Hansenula fabianii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Substrate By similarity
Active sitei94 – 941Proton donor By similarity
Binding sitei218 – 2181Substrate By similarity
Binding sitei236 – 2361Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA3
OrganismiCyberlindnera fabianii (Yeast) (Hansenula fabianii)
Taxonomic identifieri36022 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeCyberlindnera

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Orotidine 5'-phosphate decarboxylase
PRO_0000134662Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP79075.
SMRiP79075. Positions 6-264.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 623Substrate binding By similarity
Regioni92 – 10110Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79075-1 [UniParc]FASTAAdd to Basket

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MVTTLSYTQR AEAHPSPLAK RLFTVMEQKK SNLCASIDVK TTDEFLSLVD    50
TLGPYICLVK THIDIIDDFS FEGTIVPLKK LAEKHNFLIF EDRKFADIGK 100
TVKNQYASGV FKIAQWSDIT NAHGVTGAGI VKGLKEAAQE TTDEPRGLLM 150
LAELSSKGSL ATGEYTKQTV DIAKTDKDFV IGFIAQRDMG GHDEGFDWLI 200
MTPGVGLDDK GDGLGQQYRG VDEVVAGGSD IIIVGRGLFG KGRDPAVEGE 250
RYRSAGWNAY LKRCQ 265
Length:265
Mass (Da):28,986
Last modified:May 1, 1997 - v1
Checksum:iA694E609AB061BDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001561 Genomic DNA. Translation: BAA19409.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB001561 Genomic DNA. Translation: BAA19409.1 .

3D structure databases

ProteinModelPortali P79075.
SMRi P79075. Positions 6-264.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transformation system for a wastewater treatment yeast, Hansenula fabianii J640: isolation of the orotidine-5'-phosphate decarboxylase gene (URA3) and uracil auxotrophic mutants."
    Kato M., Iefuji H., Miyake K., Iimura Y.
    Appl. Microbiol. Biotechnol. 48:621-625(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: J640.

Entry informationi

Entry nameiPYRF_CYBFA
AccessioniPrimary (citable) accession number: P79075
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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