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Protein

Tip elongation protein 1

Gene

tip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2.2 Publications

GO - Molecular functioni

  • microtubule binding Source: PomBase
  • microtubule plus-end binding Source: PomBase

GO - Biological processi

  • cellular protein localization Source: PomBase
  • cytoplasmic microtubule organization Source: PomBase
  • establishment of cell polarity regulating cell shape Source: PomBase
  • microtubule cytoskeleton organization Source: PomBase
  • nuclear migration involved in conjugation with cellular fusion Source: PomBase
  • protein localization to cell cortex of cell tip Source: PomBase

Names & Taxonomyi

Protein namesi
Recommended name:
Tip elongation protein 1
Alternative name(s):
Protein noc1
Gene namesi
Name:tip1
Synonyms:noc1
ORF Names:SPAC3C7.12
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3C7.12
PomBaseiSPAC3C7.12 tip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835441 – 461Tip elongation protein 1Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82Phosphoserine1 Publication1
Modified residuei84Phosphoserine1 Publication1
Modified residuei289Phosphoserine1 Publication1
Modified residuei294Phosphoserine1 Publication1
Modified residuei305Phosphoserine1 Publication1
Modified residuei367Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP79065
PaxDbiP79065
PRIDEiP79065

PTM databases

iPTMnetiP79065

Interactioni

Subunit structurei

Monomer. Interacts with tea1 and tea2. Interacts with tea4 in the presence of tea1.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • microtubule binding Source: PomBase
  • microtubule plus-end binding Source: PomBase

Protein-protein interaction databases

BioGridi279479, 109 interactors
DIPiDIP-35371N
IntActiP79065, 8 interactors
STRINGi4896.SPAC3C7.12.1

Structurei

3D structure databases

ProteinModelPortaliP79065
SMRiP79065
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 69CAP-GlyPROSITE-ProRule annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili134 – 418Sequence analysisAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi77 – 119Ser-richAdd BLAST43

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiP79065
OMAiNIGKNDG
OrthoDBiEOG092C2WGB
PhylomeDBiP79065

Family and domain databases

Gene3Di2.30.30.190, 1 hit
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
PfamiView protein in Pfam
PF01302 CAP_GLY, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 1 hit
SUPFAMiSSF74924 SSF74924, 1 hit
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 1 hit
PS50245 CAP_GLY_2, 1 hit

Sequencei

Sequence statusi: Complete.

P79065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPLGSVVEV ITGERGFVRY AGEVENRKGV YVGLELLPEF AEFGKNRGVV
60 70 80 90 100
DGREYFKTKN NEKTGIFVPF DKCKLASSIS SSPSPKIDGT AASIGMGFPP
110 120 130 140 150
MSPNLQSSIP RLTNVSSSSN LSMNTISSTA LTPTEKILQK RIEDLLYERQ
160 170 180 190 200
NHQQQLEEVL ATVDQLQSLV TNFNDQQDEV DELRERITLK EERIQQMRNE
210 220 230 240 250
ASQRRFEFKT TIECLEESSN RAIETYENRI AELEAQLEMY MSGKSEDDLL
260 270 280 290 300
FSLQQERDYA LNQVEILQER VDTLMKQKAN SSTANEKLSH MESSSPTLTN
310 320 330 340 350
ASFESPKRGK GSNDLPENHP QRRQTLEFYE IEIEVLREKV EKLQALSDEK
360 370 380 390 400
DFYISKLEKS LDRNDTTPVP SDEKLSNYAA EKENLVSRIS ELEHTIEQLT
410 420 430 440 450
INNERDNERM SPAEFELETT QEVEENDSDS HDDEETWCEV CETNNHSLQE
460
CPTVFGSTDE A
Length:461
Mass (Da):52,607
Last modified:May 1, 1997 - v1
Checksum:i66CCDB96146F86D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59915 mRNA Translation: AAC33366.1
CU329670 Genomic DNA Translation: CAB16742.1
PIRiT38698
RefSeqiNP_593613.1, NM_001019044.2

Genome annotation databases

EnsemblFungiiSPAC3C7.12.1; SPAC3C7.12.1:pep; SPAC3C7.12
GeneIDi2543044
KEGGispo:SPAC3C7.12

Similar proteinsi

Entry informationi

Entry nameiTIP1_SCHPO
AccessioniPrimary (citable) accession number: P79065
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health