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Protein

ATP-dependent helicase rhp16

Gene

rhp16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi281 – 2888ATPPROSITE-ProRule annotation
Zinc fingeri609 – 65244RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • nucleotide-excision repair Source: PomBase
  • protein ubiquitination Source: PomBase
  • pyrimidine dimer repair Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase rhp16 (EC:3.6.4.-)
Alternative name(s):
DNA repair protein rhp16
RAD16 homolog
Gene namesi
Name:rhp16
ORF Names:SPCC330.01c, SPCC613.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

PomBaseiSPCC330.01c. rhp16.

Subcellular locationi

GO - Cellular componenti

  • nucleotide-excision repair complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861ATP-dependent helicase rhp16PRO_0000056131Add
BLAST

Proteomic databases

MaxQBiP79051.

Interactioni

Protein-protein interaction databases

MINTiMINT-4691930.

Structurei

3D structure databases

ProteinModelPortaliP79051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini268 – 442175Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini695 – 848154Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi393 – 3964DEAH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri609 – 65244RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000179829.
InParanoidiP79051.
OrthoDBiEOG092C0L0F.
PhylomeDBiP79051.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P79051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSCNKINS NSNKGKENMH FVLDDNGDSK GNASNQQVER DDKLDMETTR
60 70 80 90 100
WNGKEFEEPL STNKKLIIQS NNTSSQHSTP PLSISDTSTH TGSSTDNVEA
110 120 130 140 150
NPNTGFSSAR KRSLRSSNLK KKFVPLSSPE ESNESEFIDD DESDEVASII
160 170 180 190 200
DIKEDETFDS KVEIPEAAPS SSTESDEESI PLSYQSKRRR VSARASSSAS
210 220 230 240 250
SSSRTQAKSI PSHERTHYRL IRQHPELEHV WEKLEEEAPR EVKQIEQPKE
260 270 280 290 300
LVLNLLPFQR EGVYWLKRQE DSSFGGGILA DEMGMGKTIQ TIALLLSEPR
310 320 330 340 350
GKPTLVVAPV VAIMQWKEEI DTHTNKALST YLYYGQARDI SGEELSSYDV
360 370 380 390 400
VLTSYNVIES VYRKERSGFR RKNGVVKEKS LLHQMEFYRI ILDEAHGIKS
410 420 430 440 450
RTCNTARAVC GLRTTRKICL SGTPLQNRIG ELFSLLRFLR ADPFAYYYCL
460 470 480 490 500
QCECKSLHWR FSDRSNCDEC GHKPMSHTCY FNAEMLKPIQ KFGYEGPGKL
510 520 530 540 550
AFKKVHSLLK HIMLRRTKLE RADDLGLPPR VVEVRKDLFN EEEEDVYQSL
560 570 580 590 600
YMDSKRKFNT YLAEGVVLNN YANIFQLITR MRQMADHPDL VLASKRKTVD
610 620 630 640 650
IENQENIVCK ICDEVAQDAI ESRCHHTFCR LCVTEYINAA GDGENVNCPS
660 670 680 690 700
CFIPLSIDLS APALEDFSEE KFKNASILNR IDMNSWRSST KIEALVEELY
710 720 730 740 750
LLRKKDRTLK SIVFSQFTSM LDLIHWRLRK AGFNCVKLDG GMTPKARAAT
760 770 780 790 800
IEAFSNDINI TIFLVSLKAG GVALNLTEAS QVFMMDPWWN GAVQWQAMDR
810 820 830 840 850
IHRIGQKRPI KVITLCIENS IESKIIELQE KKAQMIHATI DQDEKALNQL
860
SVEDMQFLFS N
Length:861
Mass (Da):98,003
Last modified:June 1, 2001 - v2
Checksum:i092EF1E4E0D16052
GO

Sequence cautioni

The sequence CAA21065 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1056ANPNTG → VKSQYR in AAB49515 (PubMed:8879272).Curated
Sequence conflicti111 – 12313KRSLR…LKKKF → NVIKVLEFEKV in AAB49515 (PubMed:8879272).CuratedAdd
BLAST
Sequence conflicti425 – 4262LQ → FE in AAB49515 (PubMed:8879272).Curated
Sequence conflicti506 – 5149HSLLKHIML → DSLSMV in AAB49515 (PubMed:8879272).Curated
Sequence conflicti522 – 5276ADDLGL → RIPWI in AAB49515 (PubMed:8879272).Curated
Sequence conflicti536 – 5372KD → R in AAB49515 (PubMed:8879272).Curated
Sequence conflicti808 – 8092RP → GR in AAB49515 (PubMed:8879272).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83324 Genomic DNA. Translation: AAB49515.1.
CU329672 Genomic DNA. Translation: CAA21065.1. Different initiation.
AB027876 Genomic DNA. Translation: BAA87180.1.
PIRiT41479.
T52472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83324 Genomic DNA. Translation: AAB49515.1.
CU329672 Genomic DNA. Translation: CAA21065.1. Different initiation.
AB027876 Genomic DNA. Translation: BAA87180.1.
PIRiT41479.
T52472.

3D structure databases

ProteinModelPortaliP79051.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4691930.

Proteomic databases

MaxQBiP79051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

PomBaseiSPCC330.01c. rhp16.

Phylogenomic databases

HOGENOMiHOG000179829.
InParanoidiP79051.
OrthoDBiEOG092C0L0F.
PhylomeDBiP79051.

Miscellaneous databases

PROiP79051.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHP16_SCHPO
AccessioniPrimary (citable) accession number: P79051
Secondary accession number(s): O74911, Q9UU12, Q9UU98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.