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Protein

ATP-dependent helicase rhp16

Gene

rhp16

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi281 – 288ATPPROSITE-ProRule annotation8
Zinc fingeri609 – 652RING-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

  • nucleotide-excision repair Source: PomBase
  • pyrimidine dimer repair by nucleotide-excision repair Source: PomBase

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase rhp16 (EC:3.6.4.-)
Alternative name(s):
DNA repair protein rhp16
RAD16 homolog
Gene namesi
Name:rhp16
ORF Names:SPCC330.01c, SPCC613.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

PomBaseiSPCC330.01c rhp16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000561311 – 861ATP-dependent helicase rhp16Add BLAST861

Proteomic databases

MaxQBiP79051
PaxDbiP79051
PRIDEiP79051

Interactioni

Protein-protein interaction databases

STRINGi4896.SPCC330.01c.1

Structurei

3D structure databases

ProteinModelPortaliP79051
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 442Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini695 – 848Helicase C-terminalPROSITE-ProRule annotationAdd BLAST154

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi393 – 396DEAH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri609 – 652RING-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

HOGENOMiHOG000179829
InParanoidiP79051
KOiK15083
OrthoDBiEOG092C0L0F
PhylomeDBiP79051

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.30.40.10, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
IPR018957 Znf_C3HC4_RING-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
PF00097 zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

P79051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTSCNKINS NSNKGKENMH FVLDDNGDSK GNASNQQVER DDKLDMETTR
60 70 80 90 100
WNGKEFEEPL STNKKLIIQS NNTSSQHSTP PLSISDTSTH TGSSTDNVEA
110 120 130 140 150
NPNTGFSSAR KRSLRSSNLK KKFVPLSSPE ESNESEFIDD DESDEVASII
160 170 180 190 200
DIKEDETFDS KVEIPEAAPS SSTESDEESI PLSYQSKRRR VSARASSSAS
210 220 230 240 250
SSSRTQAKSI PSHERTHYRL IRQHPELEHV WEKLEEEAPR EVKQIEQPKE
260 270 280 290 300
LVLNLLPFQR EGVYWLKRQE DSSFGGGILA DEMGMGKTIQ TIALLLSEPR
310 320 330 340 350
GKPTLVVAPV VAIMQWKEEI DTHTNKALST YLYYGQARDI SGEELSSYDV
360 370 380 390 400
VLTSYNVIES VYRKERSGFR RKNGVVKEKS LLHQMEFYRI ILDEAHGIKS
410 420 430 440 450
RTCNTARAVC GLRTTRKICL SGTPLQNRIG ELFSLLRFLR ADPFAYYYCL
460 470 480 490 500
QCECKSLHWR FSDRSNCDEC GHKPMSHTCY FNAEMLKPIQ KFGYEGPGKL
510 520 530 540 550
AFKKVHSLLK HIMLRRTKLE RADDLGLPPR VVEVRKDLFN EEEEDVYQSL
560 570 580 590 600
YMDSKRKFNT YLAEGVVLNN YANIFQLITR MRQMADHPDL VLASKRKTVD
610 620 630 640 650
IENQENIVCK ICDEVAQDAI ESRCHHTFCR LCVTEYINAA GDGENVNCPS
660 670 680 690 700
CFIPLSIDLS APALEDFSEE KFKNASILNR IDMNSWRSST KIEALVEELY
710 720 730 740 750
LLRKKDRTLK SIVFSQFTSM LDLIHWRLRK AGFNCVKLDG GMTPKARAAT
760 770 780 790 800
IEAFSNDINI TIFLVSLKAG GVALNLTEAS QVFMMDPWWN GAVQWQAMDR
810 820 830 840 850
IHRIGQKRPI KVITLCIENS IESKIIELQE KKAQMIHATI DQDEKALNQL
860
SVEDMQFLFS N
Length:861
Mass (Da):98,003
Last modified:June 1, 2001 - v2
Checksum:i092EF1E4E0D16052
GO

Sequence cautioni

The sequence CAA21065 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100 – 105ANPNTG → VKSQYR in AAB49515 (PubMed:8879272).Curated6
Sequence conflicti111 – 123KRSLR…LKKKF → NVIKVLEFEKV in AAB49515 (PubMed:8879272).CuratedAdd BLAST13
Sequence conflicti425 – 426LQ → FE in AAB49515 (PubMed:8879272).Curated2
Sequence conflicti506 – 514HSLLKHIML → DSLSMV in AAB49515 (PubMed:8879272).Curated9
Sequence conflicti522 – 527ADDLGL → RIPWI in AAB49515 (PubMed:8879272).Curated6
Sequence conflicti536 – 537KD → R in AAB49515 (PubMed:8879272).Curated2
Sequence conflicti808 – 809RP → GR in AAB49515 (PubMed:8879272).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S83324 Genomic DNA Translation: AAB49515.1
CU329672 Genomic DNA Translation: CAA21065.1 Different initiation.
AB027876 Genomic DNA Translation: BAA87180.1
PIRiT41479
T52472
RefSeqiNP_587701.1, NM_001022696.2

Genome annotation databases

GeneIDi2538860
KEGGispo:SPCC330.01c

Similar proteinsi

Entry informationi

Entry nameiRHP16_SCHPO
AccessioniPrimary (citable) accession number: P79051
Secondary accession number(s): O74911, Q9UU12, Q9UU98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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