P79023 (AROG_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited
EC=2.5.1.54

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase
DAHP synthase
Phospho-2-keto-3-deoxyheptonate aldolase

Gene names

Name:	ARO4
ORF Names:	CaO19.4060, CaO19.11542

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate.
Enzyme regulation	Inhibited by tyrosine By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.
Sequence similarities	Belongs to the class-I DAHP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Transferase
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited		PRO_0000140850

Sequences

	Sequence		Length	Mass (Da)
	P79023 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 11E5E324C8D7B6DB	FASTA	370	40,291
	10 20 30 40 50 60 MSKTPVPTEY DDTRILGYDP LVPPALLQHE IKASAESLDV VIKGRYDSAQ ILKGNDDRCI 70 80 90 100 110 120 VIVGPCSIHD PPQALEYGKR LKKLADELKD DLVIIMRAYL EKPRTTVGWK GLINDPDVDN 130 140 150 160 170 180 SFDINRGLKI SRQLYSDLTS VVGLPIGSEM LDTISPQYFS DFLSFGAIGA RTTESQLHRE 190 200 210 220 230 240 LASGLSFPIG FKNGTDGGLA VALDAVQASS KGHHFMGVTK NGMAAITTTK GNDCCFIILR 250 260 270 280 290 300 GGKKITNYDV ESVKAAKEAI AKCTDPSIKL MVDCSHDNSR KDYRNQPQVL DSVAEQISNG 310 320 330 340 350 360 EDSIIGVMIE SNIHEGKQPM PPAGSGKEAL KYGVSITDGC VSWETTVEML TKLSQAVQTR 370 RSLKKQKVSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Sousa S., Pereira S.A., Livi G.P. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11651 / B792 / 171D.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[3]	"Aromatic amino-acid biosynthesis in Candida albicans: identification of the ARO4 gene encoding a second DAHP synthase." Pereira S.A., Livi G.P. Curr. Genet. 29:441-445(1996) [PubMed: 8625423] [Abstract] Cited for: PARTIAL NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U53216 Genomic DNA. Translation: AAB48240.1. AACQ01000243 Genomic DNA. Translation: EAK91481.1. AACQ01000242 Genomic DNA. Translation: EAK91490.1.
PIR	S68093.
RefSeq	XP_710729.1. XM_705637.1. XP_710738.1. XM_705646.1.
3D structure databases
ProteinModelPortal	P79023.
SMR	P79023. Positions 14-366.
ModBase	Search...
Protein-protein interaction databases
STRING	P79023.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3647658. 3647668.
KEGG	cal:CaO19.11542. cal:CaO19.4060.
Organism-specific databases
CGD	CAL0004867. ARO4.
Phylogenomic databases
OMA	ITTTKGN.
PhylomeDB	P79023.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01626.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROG_CANAL

Accession

Primary (citable) accession number: P79023
Secondary accession number(s): Q59LX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	January 25, 2012
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program