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Protein

Alpha-L-arabinofuranosidase axhA

Gene

axhA

Organism
Aspergillus niger
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.

Catalytic activityi

Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.

GO - Molecular functioni

  1. alpha-L-arabinofuranosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. L-arabinose metabolic process Source: InterPro
  2. xylan catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Protein family/group databases

CAZyiGH62. Glycoside Hydrolase Family 62.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-arabinofuranosidase axhA (EC:3.2.1.55)
Alternative name(s):
Arabinoxylan arabinofuranohydrolase axhA
Gene namesi
Name:axhA
OrganismiAspergillus niger
Taxonomic identifieri5061 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

  1. Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 332306Alpha-L-arabinofuranosidase axhAPRO_0000008034Add
BLAST

Expressioni

Inductioni

Mainly expressed when grown on xylan and much less on L-arabitol, L-arabinose and D-xylose. Expression is under the control of the carbon catabolite repressor creA.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP79019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 62 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG81570.

Family and domain databases

InterProiIPR005193. GH62_arabinosidase.
IPR023296. Glyco_hydro_beta-prop.
[Graphical view]
PfamiPF03664. Glyco_hydro_62. 1 hit.
[Graphical view]
SUPFAMiSSF75005. SSF75005. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P79019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLKAKGSL LSSGIYLIAL APFVNAKCAL PSTYSWTSTD ALATPKSGWT
60 70 80 90 100
ALKDFTDVVS NGKHIVYAST TDTQGNYGSM GFGAFSDWSD MASASQTATS
110 120 130 140 150
FSAVAPTLFY FQPKSIWVLA YQWGSSTFTY RTSQDPTNVN GWSSEQALFT
160 170 180 190 200
GKISGSSTGA IDQTVIGDDT NMYLFFAGDN GKIYRSSMSI NDFPGSFGSQ
210 220 230 240 250
YEEILSGATN DLFEAVQVYT VDGGEGDSKY LMIVEAIGST GHRYFRSFTA
260 270 280 290 300
SSLGGEWTAQ AASEDQPFAG KANSGATWTD DISHGDLVRN NPDQTMTVDP
310 320 330
CNLQLLYQGH DPNSNSDYNL LPWKPGVLTL KQ
Length:332
Mass (Da):35,837
Last modified:May 1, 1997 - v1
Checksum:iF6EEE44EB8C43FEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78011 Genomic DNA. Translation: CAB01409.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78011 Genomic DNA. Translation: CAB01409.1.

3D structure databases

ProteinModelPortaliP79019.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH62. Glycoside Hydrolase Family 62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG81570.

Family and domain databases

InterProiIPR005193. GH62_arabinosidase.
IPR023296. Glyco_hydro_beta-prop.
[Graphical view]
PfamiPF03664. Glyco_hydro_62. 1 hit.
[Graphical view]
SUPFAMiSSF75005. SSF75005. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Arabinoxylan degradation by fungi: characterization of the arabinoxylan-arabinofuranohydrolase encoding genes from Aspergillus niger and Aspergillus tubingensis."
    Gielkens M.M.C., Visser J., de Graaff L.H.
    Curr. Genet. 31:22-29(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, INDUCTION.
    Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

Entry informationi

Entry nameiAXHA_ASPNG
AccessioniPrimary (citable) accession number: P79019
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.