Reviewed, UniProtKB/Swiss-Prot P79017 (ALL2_ASPFU)

Names and origin

Protein names

Recommended name:
    Major allergen Asp f 2
Alternative name(s):
    Allergen Asp f II
    Allergen=Asp f 2

Gene names

ORF Names:

AFUA_4G09580

Organism

Aspergillus fumigatus (Sartorya fumigata) [Complete proteome]

Taxonomic identifier

5085 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Secreted. Note: Cell-associated.
Allergenic properties	Causes an allergic reaction in human. Associated with allergic bronchopulmonary aspergillosis.
Sequence similarities	Belongs to the ZPS1 family.
Sequence caution	The sequence EAL89830.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 310	294	Major allergen Asp f 2		PRO_0000041748
Amino acid modifications
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	87	1	N-linked (GlcNAc...) Potential
	Glycosylation	143	1	N-linked (GlcNAc...) Potential
	Glycosylation	216	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	61 – 64	4	RRQI → SARD in AAB07620. Ref.3
	Sequence conflict	227 – 228	2	LQ → FE in AAC69357. Ref.1
	Sequence conflict	227 – 228	2	LQ → FE in AAB07620. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P79017-1 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 4736C6F9DD44387A	FASTA	310	32,838
	10 20 30 40 50 60 MAALLRLAVL LPLAAPLVAT LPTSPVPIAA RATPHEPVFF SWDAGAVTSF PIHSSCNATQ 70 80 90 100 110 120 RRQIEAGLNE AVELARHAKA HILRWGNESE IYRKYFGNRP TMEAVGAYDV IVNGDKANVL 130 140 150 160 170 180 FRCDNPDGNC ALEGWGGHWR GANATSETVI CDRSYTTRRW LVSMCSQGYT VAGSETNTFW 190 200 210 220 230 240 ASDLMHRLYH VPAVGQGWVD HFADGYDEVI ALAKSNGTES THDSEALQYF ALEAYAFDIA 250 260 270 280 290 300 APGVGCAGES HGPDQGHDTG SASAPASTST SSSSSGSGSG ATTTPTDSPS ATIDVPSNCH 310 THEGGQLHCT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Immunological characterization of Asp f 2, a major allergen from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis." Banerjee B., Greenberger P.A., Fink J.N., Kurup V.P. Infect. Immun. 66:5175-5182(1998) [PubMed: 9784519] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 42202 / AF-102 / Ag 507.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Af293 / CBS 101355 / FGSC A1100.
[3]	"Molecular cloning and expression of a recombinant Aspergillus fumigatus protein Asp f II with significant immunoglobulin E reactivity in allergic bronchopulmonary aspergillosis." Banerjee B., Kurup V.P., Phadnis S., Greenberger P.A., Fink J.N. J. Lab. Clin. Med. 127:253-262(1996) [PubMed: 9273358] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-310. Strain: ATCC 42202 / AF-102 / Ag 507.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U56938 Genomic DNA. Translation: AAC69357.1. AAHF01000005 Genomic DNA. Translation: EAL89830.1. Sequence problems. U20722 mRNA. Translation: AAB07620.1.
RefSeq	XP_751868.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3509208.
KEGG	afm:AFUA_4G09580.
Phylogenomic databases
OrthoDB	EOG9RNCS1
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ALL2_ASPFU

Accession

Primary (citable) accession number: P79017
Secondary accession number(s): Q09015, Q4WPK4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 6, 2005
Last modified:	November 24, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)