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P79017 (ALL2_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major allergen Asp f 2
Alternative name(s):
Allergen Asp f II
Allergen=Asp f 2
Gene names
ORF Names:AFUA_4G09580
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifier330879 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted. Note: Cell-associated.

Allergenic properties

Causes an allergic reaction in human. Associated with allergic bronchopulmonary aspergillosis.

Sequence similarities

Belongs to the ZPS1 family.

Sequence caution

The sequence EAL89830.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseAllergen
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 310294Major allergen Asp f 2
PRO_0000041748

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation2161N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict61 – 644RRQI → SARD in AAB07620. Ref.3
Sequence conflict227 – 2282LQ → FE in AAC69357. Ref.1
Sequence conflict227 – 2282LQ → FE in AAB07620. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P79017 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 4736C6F9DD44387A

FASTA31032,838
        10         20         30         40         50         60 
MAALLRLAVL LPLAAPLVAT LPTSPVPIAA RATPHEPVFF SWDAGAVTSF PIHSSCNATQ 

        70         80         90        100        110        120 
RRQIEAGLNE AVELARHAKA HILRWGNESE IYRKYFGNRP TMEAVGAYDV IVNGDKANVL 

       130        140        150        160        170        180 
FRCDNPDGNC ALEGWGGHWR GANATSETVI CDRSYTTRRW LVSMCSQGYT VAGSETNTFW 

       190        200        210        220        230        240 
ASDLMHRLYH VPAVGQGWVD HFADGYDEVI ALAKSNGTES THDSEALQYF ALEAYAFDIA 

       250        260        270        280        290        300 
APGVGCAGES HGPDQGHDTG SASAPASTST SSSSSGSGSG ATTTPTDSPS ATIDVPSNCH 

       310 
THEGGQLHCT

« Hide

References

« Hide 'large scale' references
[1]"Immunological characterization of Asp f 2, a major allergen from Aspergillus fumigatus associated with allergic bronchopulmonary aspergillosis."
Banerjee B., Greenberger P.A., Fink J.N., Kurup V.P.
Infect. Immun. 66:5175-5182(1998) [PubMed: 9784519] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 42202 / AF-102 / Ag 507.
[2]"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus."
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. expand/collapse author list , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.
Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.
[3]"Molecular cloning and expression of a recombinant Aspergillus fumigatus protein Asp f II with significant immunoglobulin E reactivity in allergic bronchopulmonary aspergillosis."
Banerjee B., Kurup V.P., Phadnis S., Greenberger P.A., Fink J.N.
J. Lab. Clin. Med. 127:253-262(1996) [PubMed: 9273358] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 61-310.
Strain: ATCC 42202 / AF-102 / Ag 507.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U56938 Genomic DNA. Translation: AAC69357.1.
AAHF01000005 Genomic DNA. Translation: EAL89830.1. Sequence problems.
U20722 mRNA. Translation: AAB07620.1.
RefSeqXP_751868.1. XM_746775.1.

3D structure databases

ProteinModelPortalP79017.
ModBaseSearch...

Protein family/group databases

Allergome3115. Asp f 2.0101.
71. Asp f 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3509208.
KEGGafm:AFUA_4G09580.

Phylogenomic databases

eggNOGfuNOG08652.
GeneTreeEFGT00050000005064.
HOGENOMHBG324809.
OrthoDBEOG4DV8W8.

Family and domain databases

InterProIPR024079. MetalloPept_cat_dom.
[Graphical view]
Gene3DG3DSA:3.40.390.10. G3DSA:3.40.390.10. 1 hit.
ProtoNetSearch...

Entry information

Entry nameALL2_ASPFU
AccessionPrimary (citable) accession number: P79017
Secondary accession number(s): Q09015, Q4WPK4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 6, 2005
Last modified: December 14, 2011
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Allergens

Nomenclature of allergens and list of entries

SIMILARITY comments

Index of protein domains and families

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