Reviewed, UniProtKB/Swiss-Prot P79001 (PGPS1_SACPS)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	PGS1
Synonyms:	PEL1, YCLUN3W

Organism

Saccharomyces pastorianus (Lager yeast) (Saccharomyces carlsbergensis)

Taxonomic identifier

27292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-II family. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 521	521	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000056826
Regions
	Domain	177 – 203	27	PLD phosphodiesterase 1
	Domain	419 – 457	39	PLD phosphodiesterase 2
	Nucleotide binding	91 – 98	8	ATP Potential
Sites
	Active site	182	1	Potential
	Active site	184	1	Potential
	Active site	189	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	P79001-1 [UniParc]. Last modified May 1, 1997. Version 1. Checksum: 1E28ABDDB2231302	FASTA	521	59,354
	10 20 30 40 50 60 MTTRLLQLTR PHYRLLSSPF RKSSIIQRQM SASSPSPANS YLNMITKSLQ HNLQTWFHFE 70 80 90 100 110 120 PNEIDIIESP SHFYDLLKSK ISSSQKRIFI ASLYLGKSET ELIDCISQAL SKNPDLKVSF 130 140 150 160 170 180 LLDGLRGTRE LPSTCSATLL SSLVAKYGSE RVDCRLYKTP AYHGWKKIVV PKRFNEGLGL 190 200 210 220 230 240 QHMKIYGFDN EIILSGANLS NDYFTNRQDR YYLFKSANFA NYYFKLHQLI SSFSYQIVKP 250 260 270 280 290 300 KVAGNVNIIW PDSNPTIEPM KNKRKFLREA SQLLENFLQI SKHNQPISPP GQFSTIVYPI 310 320 330 340 350 360 SQFTPLFPKY NDKSTEKSTI LSLLSNIKNT SISWTFTAGY FNILPEIKAN LLATPVTEAN 370 380 390 400 410 420 VITASPFANG FYQSKGVSSN LPGAYLYLSK KFLQDVSRYN KDQAITLREW QRGVVNKPNG 430 440 450 460 470 480 WSYHAKGIWI SSRDNNDSDS WKPFITVIGS SNYTRRAYSL DLESNALIIT KDEELRNKMK 490 500 510 520 GELNDLLQYT KPVTLEDFKS DPERHVGTGV KIATSVLGKK L

References

[1]	Andersen T., Nilsson-Tillgren T. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z86109 Genomic DNA. Translation: CAB06796.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.8.5. 3401.
Family and domain databases
InterPro	IPR016270. PLipase-D_PtdSer-synthase-type. IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
Pfam	PF00614. PLDc. 2 hits. [Graphical view]
PIRSF	PIRSF000850. Phospholipase_D_PSS. 1 hit.
SMART	SM00155. PLDc. 2 hits. [Graphical view]
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGPS1_SACPS

Accession

Primary (citable) accession number: P79001

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 1997
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)