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Protein

Heat shock 70 kDa protein

Gene

HSP70

Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein
Alternative name(s):
Allergen: Alt a 3
Gene namesi
Name:HSP70
Synonyms:ALTA3
OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifieri5599 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei17. Alt a 3.
3059. Alt a 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 152›152Heat shock 70 kDa proteinPRO_0000078360Add
BLAST

Proteomic databases

PRIDEiP78983.

Structurei

3D structure databases

ProteinModelPortaliP78983.
SMRiP78983. Positions 1-57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.

Sequencei

Sequence statusi: Fragment.

P78983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KTNKIVITND KGRLSKEEIE RMLAEAEKYK AEDEAEAARI SAKNALESYA
60 70 80 90 100
YSLRNTLSDS KVDEKLDAGD KQKLTAEIDK TVQWLDDNQT ATKDEYESQQ
110 120 130 140 150
KELEGVANPI MMKFYGAGGE GGMPGGMPGG GMPGGAPGGA AGDDGPTVEE

VD
Length:152
Mass (Da):16,233
Last modified:June 19, 2001 - v2
Checksum:i87442B9F45385E6A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87807 mRNA. Translation: AAB48042.1.
U87808 mRNA. Translation: AAB48043.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87807 mRNA. Translation: AAB48042.1.
U87808 mRNA. Translation: AAB48043.1.

3D structure databases

ProteinModelPortaliP78983.
SMRiP78983. Positions 1-57.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei17. Alt a 3.
3059. Alt a 3.0101.

Proteomic databases

PRIDEiP78983.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of IgE-binding fragments of Alternaria alternata allergens."
    De Vouge M.W., Thaker A.J., Zhang L., Muradia G., Rode H., Vijay H.M.
    Int. Arch. Allergy Immunol. 116:261-268(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CROSS-REACTIVITY WITH ATOPIC HUMAN SERA.

Entry informationi

Entry nameiHSP70_ALTAL
AccessioniPrimary (citable) accession number: P78983
Secondary accession number(s): P78984
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 19, 2001
Last sequence update: June 19, 2001
Last modified: January 6, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.