Reviewed, UniProtKB/Swiss-Prot P78983 (HSP70_ALTAL)

Names and origin

Protein names

Recommended name:
    Heat shock 70 kDa protein
Alternative name(s):
    Allergen=Alt a 3

Gene names

Name:	HSP70
Synonyms:	ALTA3

Organism

Alternaria alternata (Alternaria rot fungus)

Taxonomic identifier

5599 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › mitosporic Pleosporaceae › Alternaria › Alternaria alternata group

Protein attributes

Sequence length	152 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Disease	Allergen
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Gene Ontology (GO)
Biological process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 152	›152	Heat shock 70 kDa protein		PRO_0000078360
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P78983-1 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 87442B9F45385E6A	FASTA	152	16,233
	10 20 30 40 50 60 KTNKIVITND KGRLSKEEIE RMLAEAEKYK AEDEAEAARI SAKNALESYA YSLRNTLSDS 70 80 90 100 110 120 KVDEKLDAGD KQKLTAEIDK TVQWLDDNQT ATKDEYESQQ KELEGVANPI MMKFYGAGGE 130 140 150 GGMPGGMPGG GMPGGAPGGA AGDDGPTVEE VD

References

[1]

"Molecular cloning of IgE-binding fragments of Alternaria alternata allergens." De Vouge M.W., Thaker A.J., Zhang L., Muradia G., Rode H., Vijay H.M. Int. Arch. Allergy Immunol. 116:261-268(1998) [PubMed: 9693275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CROSS-REACTIVITY WITH ATOPIC HUMAN SERA.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U87807 mRNA. Translation: AAB48042.1. U87808 mRNA. Translation: AAB48043.1.
3D structure databases
SMR	P78983. Positions 46-127.
ModBase	Search...
Family and domain databases
InterPro	IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PROSITE	PS00297. HSP70_1. Partial match. PS00329. HSP70_2. Partial match. PS01036. HSP70_3. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSP70_ALTAL

Accession

Primary (citable) accession number: P78983
Secondary accession number(s): P78984

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	June 20, 2001
Last modified:	November 24, 2009
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)