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P78968 (PPZ_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP-Z
EC=3.1.3.16
Gene names
Name:pzh1
Synonyms:phz1
ORF Names:SPAC57A7.08
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subcellular location

Cytoplasm. Note: Nucleus; nuclear rim. Ref.3

Sequence similarities

Belongs to the PPP phosphatase family. PP-Z subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Serine/threonine-protein phosphatase PP-Z
PRO_0000058890

Regions

Compositional bias69 – 746Poly-Pro
Compositional bias120 – 1245Poly-His
Compositional bias125 – 1295Poly-Ser

Sites

Active site3091Proton donor By similarity
Metal binding2481Iron By similarity
Metal binding2501Iron By similarity
Metal binding2761Iron By similarity
Metal binding2761Manganese By similarity
Metal binding3081Manganese By similarity
Metal binding3571Manganese By similarity
Metal binding4321Manganese By similarity

Amino acid modifications

Modified residue181Phosphoserine Ref.4
Modified residue5051Phosphoserine Ref.4
Modified residue5141Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P78968 [UniParc].

Last modified May 1, 1997. Version 1.
Checksum: B9F14C0FE3F93B97

FASTA51557,131
        10         20         30         40         50         60 
MGQGSSKHAD SKLDSYPSFS RSDTQGSIKS LKSLKTVLGK GKDSNHDRRT STDTTHSRHR 

        70         80         90        100        110        120 
YPETPPSLPP PPSPGILATS PAVLQKHQQE DSGNSSQSPT SPHPSNQPAM LSPSTAASQH 

       130        140        150        160        170        180 
HHHHSSSSSY AVSPTSPTSP TSSGPIGSNF DSASEHNGPV YPQDQQGPVI IPNSAISSTD 

       190        200        210        220        230        240 
PDDPETVVSL NVDEMIQRLI HVGYSRKSSK SVCLKNAEIT SICMAVREIF LSQPTLLELT 

       250        260        270        280        290        300 
PPVKIVGDVH GQYSDLIRLF EMCGFPPSSN YLFLGDYVDR GKQSLETILL LFLYKIRYPE 

       310        320        330        340        350        360 
NFFLLRGNHE CANITRVYGF YDECKRRCNI KIWKTFINTF NCLPIASVVA GKIFCVHGGL 

       370        380        390        400        410        420 
SPSLSHMDDI REIPRPTDVP DYGLLNDLLW SDPADTENDW EDNERGVSFV FNKNVIRQFL 

       430        440        450        460        470        480 
AKHDFDLICR AHMVVEDGYE FFNDRTLCTV FSAPNYCGEF DNWGAVMSVN SELLCSFELI 

       490        500        510 
KPLDQAAIRR ELKKSKRSGM AIYQSPPAEQ VTQSV

« Hide

References

« Hide 'large scale' references
[1]"Regulation of salt tolerance in fission yeast by a protein-phosphatase-Z-like Ser/Thr protein phosphatase."
Balcells L., Gomez N., Casamayor A., Clotet J., Arino J.
Eur. J. Biochem. 250:476-483(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-27, SUBCELLULAR LOCATION.
Strain: ATCC 38364 / 968.
[4]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-505 AND SER-514, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U73689 Genomic DNA. Translation: AAB96332.1.
CU329670 Genomic DNA. Translation: CAB08766.1.
AB027801 Genomic DNA. Translation: BAA87105.1.
PIRT38946.
RefSeqNP_593373.1. NM_001018805.2.

3D structure databases

ProteinModelPortalP78968.
SMRP78968. Positions 190-484.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC57A7.08-1.

Proteomic databases

PRIDEP78968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC57A7.08.1; SPAC57A7.08.1:pep; SPAC57A7.08.
GeneID2542255.
KEGGspo:SPAC57A7.08.

Organism-specific databases

PomBaseSPAC57A7.08.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172697.
KOK01090.
OrthoDBEOG479JGP.

Family and domain databases

InterProIPR004843. Metallo_PEstase_dom.
IPR011159. PPPtase_PPZ.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF000909. PPPtase_PPZ. 1 hit.
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803320.

Entry information

Entry namePPZ_SCHPO
AccessionPrimary (citable) accession number: P78968
Secondary accession number(s): O00106, Q9UU57
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

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