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Protein

Serine/threonine-protein phosphatase PP-Z

Gene

pzh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi248 – 2481Manganese 1By similarity
Metal bindingi250 – 2501Manganese 1By similarity
Metal bindingi276 – 2761Manganese 1By similarity
Metal bindingi276 – 2761Manganese 2By similarity
Metal bindingi308 – 3081Manganese 2By similarity
Active sitei309 – 3091Proton donorBy similarity
Metal bindingi357 – 3571Manganese 2By similarity
Metal bindingi432 – 4321Manganese 2By similarity

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. magnesium-dependent protein serine/threonine phosphatase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular potassium ion homeostasis Source: PomBase
  2. cellular response to cation stress Source: PomBase
  3. cellular sodium ion homeostasis Source: PomBase
  4. cellular water homeostasis Source: PomBase
  5. protein dephosphorylation Source: PomBase
  6. regulation of ATPase activity Source: PomBase
  7. regulation of cytoplasmic translation Source: PomBase
  8. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-Z (EC:3.1.3.16)
Gene namesi
Name:pzh1
Synonyms:phz1
ORF Names:SPAC57A7.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC57A7.08.

Subcellular locationi

Cytoplasm 1 Publication
Note: Nucleus; nuclear rim.

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. endoplasmic reticulum Source: PomBase
  3. nucleus Source: PomBase
  4. vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Serine/threonine-protein phosphatase PP-ZPRO_0000058890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphoserine1 Publication
Modified residuei505 – 5051Phosphoserine1 Publication
Modified residuei514 – 5141Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78968.
PRIDEiP78968.

Interactioni

Protein-protein interaction databases

BioGridi278725. 97 interactions.
MINTiMINT-4691746.
STRINGi4896.SPAC57A7.08-1.

Structurei

3D structure databases

ProteinModelPortaliP78968.
SMRiP78968. Positions 190-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 746Poly-Pro
Compositional biasi120 – 1245Poly-His
Compositional biasi125 – 1295Poly-Ser

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-Z subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
InParanoidiP78968.
KOiK06269.
OrthoDBiEOG79KPQ9.
PhylomeDBiP78968.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011159. PPPtase_PPZ.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000909. PPPtase_PPZ. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78968-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQGSSKHAD SKLDSYPSFS RSDTQGSIKS LKSLKTVLGK GKDSNHDRRT
60 70 80 90 100
STDTTHSRHR YPETPPSLPP PPSPGILATS PAVLQKHQQE DSGNSSQSPT
110 120 130 140 150
SPHPSNQPAM LSPSTAASQH HHHHSSSSSY AVSPTSPTSP TSSGPIGSNF
160 170 180 190 200
DSASEHNGPV YPQDQQGPVI IPNSAISSTD PDDPETVVSL NVDEMIQRLI
210 220 230 240 250
HVGYSRKSSK SVCLKNAEIT SICMAVREIF LSQPTLLELT PPVKIVGDVH
260 270 280 290 300
GQYSDLIRLF EMCGFPPSSN YLFLGDYVDR GKQSLETILL LFLYKIRYPE
310 320 330 340 350
NFFLLRGNHE CANITRVYGF YDECKRRCNI KIWKTFINTF NCLPIASVVA
360 370 380 390 400
GKIFCVHGGL SPSLSHMDDI REIPRPTDVP DYGLLNDLLW SDPADTENDW
410 420 430 440 450
EDNERGVSFV FNKNVIRQFL AKHDFDLICR AHMVVEDGYE FFNDRTLCTV
460 470 480 490 500
FSAPNYCGEF DNWGAVMSVN SELLCSFELI KPLDQAAIRR ELKKSKRSGM
510
AIYQSPPAEQ VTQSV
Length:515
Mass (Da):57,131
Last modified:May 1, 1997 - v1
Checksum:iB9F14C0FE3F93B97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73689 Genomic DNA. Translation: AAB96332.1.
CU329670 Genomic DNA. Translation: CAB08766.1.
AB027801 Genomic DNA. Translation: BAA87105.1.
PIRiT38946.
RefSeqiNP_593373.1. NM_001018805.2.

Genome annotation databases

EnsemblFungiiSPAC57A7.08.1; SPAC57A7.08.1:pep; SPAC57A7.08.
GeneIDi2542255.
KEGGispo:SPAC57A7.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73689 Genomic DNA. Translation: AAB96332.1.
CU329670 Genomic DNA. Translation: CAB08766.1.
AB027801 Genomic DNA. Translation: BAA87105.1.
PIRiT38946.
RefSeqiNP_593373.1. NM_001018805.2.

3D structure databases

ProteinModelPortaliP78968.
SMRiP78968. Positions 190-484.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278725. 97 interactions.
MINTiMINT-4691746.
STRINGi4896.SPAC57A7.08-1.

Proteomic databases

MaxQBiP78968.
PRIDEiP78968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC57A7.08.1; SPAC57A7.08.1:pep; SPAC57A7.08.
GeneIDi2542255.
KEGGispo:SPAC57A7.08.

Organism-specific databases

PomBaseiSPAC57A7.08.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
InParanoidiP78968.
KOiK06269.
OrthoDBiEOG79KPQ9.
PhylomeDBiP78968.

Miscellaneous databases

NextBioi20803320.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011159. PPPtase_PPZ.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000909. PPPtase_PPZ. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of salt tolerance in fission yeast by a protein-phosphatase-Z-like Ser/Thr protein phosphatase."
    Balcells L., Gomez N., Casamayor A., Clotet J., Arino J.
    Eur. J. Biochem. 250:476-483(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-27, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-505 AND SER-514, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPPZ_SCHPO
AccessioniPrimary (citable) accession number: P78968
Secondary accession number(s): O00106, Q9UU57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: February 4, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.