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P78968

- PPZ_SCHPO

UniProt

P78968 - PPZ_SCHPO

Protein

Serine/threonine-protein phosphatase PP-Z

Gene

pzh1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 May 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi248 – 2481Manganese 1By similarity
    Metal bindingi250 – 2501Manganese 1By similarity
    Metal bindingi276 – 2761Manganese 1By similarity
    Metal bindingi276 – 2761Manganese 2By similarity
    Metal bindingi308 – 3081Manganese 2By similarity
    Active sitei309 – 3091Proton donorBy similarity
    Metal bindingi357 – 3571Manganese 2By similarity
    Metal bindingi432 – 4321Manganese 2By similarity

    GO - Molecular functioni

    1. cofactor binding Source: InterPro
    2. magnesium-dependent protein serine/threonine phosphatase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular potassium ion homeostasis Source: PomBase
    2. cellular response to cation stress Source: PomBase
    3. cellular sodium ion homeostasis Source: PomBase
    4. cellular water homeostasis Source: PomBase
    5. protein dephosphorylation Source: PomBase
    6. regulation of ATPase activity Source: PomBase
    7. regulation of cytoplasmic translation Source: PomBase
    8. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP-Z (EC:3.1.3.16)
    Gene namesi
    Name:pzh1
    Synonyms:phz1
    ORF Names:SPAC57A7.08
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC57A7.08.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Nucleus; nuclear rim.

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. endoplasmic reticulum Source: PomBase
    3. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Serine/threonine-protein phosphatase PP-ZPRO_0000058890Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Phosphoserine1 Publication
    Modified residuei505 – 5051Phosphoserine1 Publication
    Modified residuei514 – 5141Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP78968.
    PRIDEiP78968.

    Interactioni

    Protein-protein interaction databases

    BioGridi278725. 97 interactions.
    MINTiMINT-4691746.
    STRINGi4896.SPAC57A7.08-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP78968.
    SMRiP78968. Positions 190-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi69 – 746Poly-Pro
    Compositional biasi120 – 1245Poly-His
    Compositional biasi125 – 1295Poly-Ser

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-Z subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172697.
    KOiK06269.
    OMAiHECANIT.
    OrthoDBiEOG79KPQ9.
    PhylomeDBiP78968.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR011159. PPPtase_PPZ.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000909. PPPtase_PPZ. 1 hit.
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78968-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQGSSKHAD SKLDSYPSFS RSDTQGSIKS LKSLKTVLGK GKDSNHDRRT    50
    STDTTHSRHR YPETPPSLPP PPSPGILATS PAVLQKHQQE DSGNSSQSPT 100
    SPHPSNQPAM LSPSTAASQH HHHHSSSSSY AVSPTSPTSP TSSGPIGSNF 150
    DSASEHNGPV YPQDQQGPVI IPNSAISSTD PDDPETVVSL NVDEMIQRLI 200
    HVGYSRKSSK SVCLKNAEIT SICMAVREIF LSQPTLLELT PPVKIVGDVH 250
    GQYSDLIRLF EMCGFPPSSN YLFLGDYVDR GKQSLETILL LFLYKIRYPE 300
    NFFLLRGNHE CANITRVYGF YDECKRRCNI KIWKTFINTF NCLPIASVVA 350
    GKIFCVHGGL SPSLSHMDDI REIPRPTDVP DYGLLNDLLW SDPADTENDW 400
    EDNERGVSFV FNKNVIRQFL AKHDFDLICR AHMVVEDGYE FFNDRTLCTV 450
    FSAPNYCGEF DNWGAVMSVN SELLCSFELI KPLDQAAIRR ELKKSKRSGM 500
    AIYQSPPAEQ VTQSV 515
    Length:515
    Mass (Da):57,131
    Last modified:May 1, 1997 - v1
    Checksum:iB9F14C0FE3F93B97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73689 Genomic DNA. Translation: AAB96332.1.
    CU329670 Genomic DNA. Translation: CAB08766.1.
    AB027801 Genomic DNA. Translation: BAA87105.1.
    PIRiT38946.
    RefSeqiNP_593373.1. NM_001018805.2.

    Genome annotation databases

    EnsemblFungiiSPAC57A7.08.1; SPAC57A7.08.1:pep; SPAC57A7.08.
    GeneIDi2542255.
    KEGGispo:SPAC57A7.08.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U73689 Genomic DNA. Translation: AAB96332.1 .
    CU329670 Genomic DNA. Translation: CAB08766.1 .
    AB027801 Genomic DNA. Translation: BAA87105.1 .
    PIRi T38946.
    RefSeqi NP_593373.1. NM_001018805.2.

    3D structure databases

    ProteinModelPortali P78968.
    SMRi P78968. Positions 190-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278725. 97 interactions.
    MINTi MINT-4691746.
    STRINGi 4896.SPAC57A7.08-1.

    Proteomic databases

    MaxQBi P78968.
    PRIDEi P78968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC57A7.08.1 ; SPAC57A7.08.1:pep ; SPAC57A7.08 .
    GeneIDi 2542255.
    KEGGi spo:SPAC57A7.08.

    Organism-specific databases

    PomBasei SPAC57A7.08.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172697.
    KOi K06269.
    OMAi HECANIT.
    OrthoDBi EOG79KPQ9.
    PhylomeDBi P78968.

    Miscellaneous databases

    NextBioi 20803320.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR011159. PPPtase_PPZ.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000909. PPPtase_PPZ. 1 hit.
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of salt tolerance in fission yeast by a protein-phosphatase-Z-like Ser/Thr protein phosphatase."
      Balcells L., Gomez N., Casamayor A., Clotet J., Arino J.
      Eur. J. Biochem. 250:476-483(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-27, SUBCELLULAR LOCATION.
      Strain: ATCC 38364 / 968.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-505 AND SER-514, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPPZ_SCHPO
    AccessioniPrimary (citable) accession number: P78968
    Secondary accession number(s): O00106, Q9UU57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3