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P78968

- PPZ_SCHPO

UniProt

P78968 - PPZ_SCHPO

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Protein
Serine/threonine-protein phosphatase PP-Z
Gene
pzh1, phz1, SPAC57A7.08
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi248 – 2481Manganese 1 By similarity
Metal bindingi250 – 2501Manganese 1 By similarity
Metal bindingi276 – 2761Manganese 1 By similarity
Metal bindingi276 – 2761Manganese 2 By similarity
Metal bindingi308 – 3081Manganese 2 By similarity
Active sitei309 – 3091Proton donor By similarity
Metal bindingi357 – 3571Manganese 2 By similarity
Metal bindingi432 – 4321Manganese 2 By similarity

GO - Molecular functioni

  1. cofactor binding Source: InterPro
  2. magnesium-dependent protein serine/threonine phosphatase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular potassium ion homeostasis Source: PomBase
  2. cellular response to cation stress Source: PomBase
  3. cellular sodium ion homeostasis Source: PomBase
  4. cellular water homeostasis Source: PomBase
  5. protein dephosphorylation Source: PomBase
  6. regulation of ATPase activity Source: PomBase
  7. regulation of cytoplasmic translation Source: PomBase
  8. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP-Z (EC:3.1.3.16)
Gene namesi
Name:pzh1
Synonyms:phz1
ORF Names:SPAC57A7.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC57A7.08.

Subcellular locationi

Cytoplasm
Note: Nucleus; nuclear rim.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. endoplasmic reticulum Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Serine/threonine-protein phosphatase PP-Z
PRO_0000058890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphoserine1 Publication
Modified residuei505 – 5051Phosphoserine1 Publication
Modified residuei514 – 5141Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78968.
PRIDEiP78968.

Interactioni

Protein-protein interaction databases

BioGridi278725. 97 interactions.
MINTiMINT-4691746.
STRINGi4896.SPAC57A7.08-1.

Structurei

3D structure databases

ProteinModelPortaliP78968.
SMRiP78968. Positions 190-484.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 746Poly-Pro
Compositional biasi120 – 1245Poly-His
Compositional biasi125 – 1295Poly-Ser

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172697.
KOiK06269.
OMAiHECANIT.
OrthoDBiEOG79KPQ9.
PhylomeDBiP78968.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011159. PPPtase_PPZ.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000909. PPPtase_PPZ. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78968-1 [UniParc]FASTAAdd to Basket

« Hide

MGQGSSKHAD SKLDSYPSFS RSDTQGSIKS LKSLKTVLGK GKDSNHDRRT    50
STDTTHSRHR YPETPPSLPP PPSPGILATS PAVLQKHQQE DSGNSSQSPT 100
SPHPSNQPAM LSPSTAASQH HHHHSSSSSY AVSPTSPTSP TSSGPIGSNF 150
DSASEHNGPV YPQDQQGPVI IPNSAISSTD PDDPETVVSL NVDEMIQRLI 200
HVGYSRKSSK SVCLKNAEIT SICMAVREIF LSQPTLLELT PPVKIVGDVH 250
GQYSDLIRLF EMCGFPPSSN YLFLGDYVDR GKQSLETILL LFLYKIRYPE 300
NFFLLRGNHE CANITRVYGF YDECKRRCNI KIWKTFINTF NCLPIASVVA 350
GKIFCVHGGL SPSLSHMDDI REIPRPTDVP DYGLLNDLLW SDPADTENDW 400
EDNERGVSFV FNKNVIRQFL AKHDFDLICR AHMVVEDGYE FFNDRTLCTV 450
FSAPNYCGEF DNWGAVMSVN SELLCSFELI KPLDQAAIRR ELKKSKRSGM 500
AIYQSPPAEQ VTQSV 515
Length:515
Mass (Da):57,131
Last modified:May 1, 1997 - v1
Checksum:iB9F14C0FE3F93B97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73689 Genomic DNA. Translation: AAB96332.1.
CU329670 Genomic DNA. Translation: CAB08766.1.
AB027801 Genomic DNA. Translation: BAA87105.1.
PIRiT38946.
RefSeqiNP_593373.1. NM_001018805.2.

Genome annotation databases

EnsemblFungiiSPAC57A7.08.1; SPAC57A7.08.1:pep; SPAC57A7.08.
GeneIDi2542255.
KEGGispo:SPAC57A7.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U73689 Genomic DNA. Translation: AAB96332.1 .
CU329670 Genomic DNA. Translation: CAB08766.1 .
AB027801 Genomic DNA. Translation: BAA87105.1 .
PIRi T38946.
RefSeqi NP_593373.1. NM_001018805.2.

3D structure databases

ProteinModelPortali P78968.
SMRi P78968. Positions 190-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278725. 97 interactions.
MINTi MINT-4691746.
STRINGi 4896.SPAC57A7.08-1.

Proteomic databases

MaxQBi P78968.
PRIDEi P78968.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC57A7.08.1 ; SPAC57A7.08.1:pep ; SPAC57A7.08 .
GeneIDi 2542255.
KEGGi spo:SPAC57A7.08.

Organism-specific databases

PomBasei SPAC57A7.08.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172697.
KOi K06269.
OMAi HECANIT.
OrthoDBi EOG79KPQ9.
PhylomeDBi P78968.

Miscellaneous databases

NextBioi 20803320.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011159. PPPtase_PPZ.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF000909. PPPtase_PPZ. 1 hit.
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of salt tolerance in fission yeast by a protein-phosphatase-Z-like Ser/Thr protein phosphatase."
    Balcells L., Gomez N., Casamayor A., Clotet J., Arino J.
    Eur. J. Biochem. 250:476-483(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-27, SUBCELLULAR LOCATION.
    Strain: ATCC 38364 / 968.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-505 AND SER-514, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPPZ_SCHPO
AccessioniPrimary (citable) accession number: P78968
Secondary accession number(s): O00106, Q9UU57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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