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Protein

Mating factor M secretion protein mam1

Gene

mam1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Required in S.pombe M (minus) cells for production of M-factor pheromone. Involved in the transport of the farnesyl-derivation of the M-factor pheromone.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi469 – 476ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1135 – 1142ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • oligopeptide transmembrane transporter activity Source: PomBase
  • oligopeptide-transporting ATPase activity Source: PomBase

GO - Biological processi

  • peptide pheromone export by transmembrane transport Source: PomBase
  • peptide pheromone transmembrane export involved in conjugation with cellular fusion Source: PomBase
  • response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Pheromone response, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.206.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Mating factor M secretion protein mam1
Alternative name(s):
Multiple drug resistance protein homolog
P-glycoprotein
Gene namesi
Name:mam1
ORF Names:SPBC25B2.02c, SPBC2G5.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC25B2.02c.
PomBaseiSPBC25B2.02c. mam1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 91CytoplasmicSequence analysisAdd BLAST91
Transmembranei92 – 112HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini113 – 153ExtracellularSequence analysisAdd BLAST41
Transmembranei154 – 174HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini175 – 250CytoplasmicSequence analysisAdd BLAST76
Transmembranei251 – 271HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini272 – 778ExtracellularSequence analysisAdd BLAST507
Transmembranei779 – 799HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini800 – 897CytoplasmicSequence analysisAdd BLAST98
Transmembranei898 – 918HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini919 – 1336ExtracellularSequence analysisAdd BLAST418

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytoplasm Source: PomBase
  • integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933691 – 1336Mating factor M secretion protein mam1Add BLAST1336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi437N-linked (GlcNAc...)Sequence analysis1
Glycosylationi454N-linked (GlcNAc...)Sequence analysis1
Glycosylationi536N-linked (GlcNAc...)Sequence analysis1
Glycosylationi664N-linked (GlcNAc...)Sequence analysis1
Glycosylationi697N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1011N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1063N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1120N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1235N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1280N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP78966.
PRIDEiP78966.

Interactioni

Protein-protein interaction databases

MINTiMINT-4691729.

Structurei

3D structure databases

ProteinModelPortaliP78966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 396ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST293
Domaini433 – 668ABC transporter 1PROSITE-ProRule annotationAdd BLAST236
Domaini781 – 1066ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST286
Domaini1099 – 1331ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP78966.
KOiK05658.
OMAiDTVKCLN.
OrthoDBiEOG092C02C4.
PhylomeDBiP78966.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIHSDLSLP QFEHASIDPP SYSPQKSSFE EKKHNFSITN KSLETLRSQE
60 70 80 90 100
SPCSTTFPVS DRKDALLNIP TVVDDEFQHT EELAGVSSWS DFFYLFHFSD
110 120 130 140 150
IPLIFGTLIF TCLSAALEPL MTWTTGKVFD ALSQYATSQI TLGKMISLIN
160 170 180 190 200
FNSLLITIFG LASCVFSFGV RFLWQYLSAI AGKRARSLCF HVLSSKSSTF
210 220 230 240 250
YSLTESKSGL VNSVDRCIQF YEKSISLPMF HIAENLAISL SCLIISFRYS
260 270 280 290 300
WSLTLVVLAS YPIIILVVGF INSFLSSAYE KDRKSSEKAA SILEKSISAI
310 320 330 340 350
QTVIFHSMQD TEYRYFADAC STSSKSFLRF SFLDAFQGGV SQFFLYSVFF
360 370 380 390 400
QGLWFGNHLA TTKRVNVGQV VTVFGSCLSV ASSLQQILPA IPDLIKGKFS
410 420 430 440 450
SHFIKTLCES HDPIEAAKRS AAKIKSISFE RGFRFDNVSF AYPSRDENLF
460 470 480 490 500
SLINVSVFIP FGELVHIIGP SGSGKSTFIS LLLRYFSPTY GNIYLDDFPL
510 520 530 540 550
EEIDEHVLGS TITLVCQQPV IFDMTIRENI IMRNENASES DFEEVCRLAL
560 570 580 590 600
VDEFALTFDQ SYDTPCKEAS LSGGQQQRIA LARALLRDTE ILILDEPTSA
610 620 630 640 650
LDPITKNLVM DAIRAHRKGK TTLVITHDMS QINNDELVLV IDKGHLIQRC
660 670 680 690 700
ARKELVLFED FENNVSIDEK VLKEEADNPF ILPNEESLLE KYWINYNESF
710 720 730 740 750
SQLSRESLFT SLESPFTDIE SPTIVSRRKI VEQRKLRMEK ESFQETNVDQ
760 770 780 790 800
TFHLFDDKEH ACSLTLIFKS IWKVKKLRWF FLLGLLTSLI QGASVPIFAY
810 820 830 840 850
VISKCLNLFM QIDPSIGVAF WSSMVLVVAA GSGASYFFSH YIFSISAKIW
860 870 880 890 900
CDHYRLLAVK VLFTQDQAWF DQIENYPLVL SKILVNNISD MRNMISSLIE
910 920 930 940 950
EVFIAFTMAI IGIAWSFATG WRLAAVLVAV SPILCLTSRM FSYIYVSTER
960 970 980 990 1000
MCQDVVISTT SILHKTIVNL DTIKGYSVLS FFRENHKNSL RKSWEAFKRR
1010 1020 1030 1040 1050
AFWTSLGFAI NNSLLYFVRA LLFYCSSIFI SKEFYTVEQM VQVLSLATFT
1060 1070 1080 1090 1100
LLMASTCIMS LPNVSASRIA TSRVLKLSSL KPGNLHKSGY LKFPLVGKIE
1110 1120 1130 1140 1150
FDGVSFAYPD SERNHLALNN VSLSIEAREK VAIVGISGSG KSTLVELLRK
1160 1170 1180 1190 1200
TYPSEDIYID GYPLTNIDTN WLLKKVAIVD QKPHLLGSTI LESLLYGVDR
1210 1220 1230 1240 1250
DINSVMDALD KTYMTEVIQN LPNGLDTPLL EFSKNFSGGQ IQRLAFARAL
1260 1270 1280 1290 1300
LRNPRLLILD ECTSALDSKS SLLLEKTIQN LSCTVLIITH QPSLMKLADR
1310 1320 1330
IIVMDSGIVK ESGSFDELMN RHTHFWKLIH RGEWIE
Length:1,336
Mass (Da):150,887
Last modified:May 1, 1997 - v1
Checksum:iFF20666B8852CAB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66305 Genomic DNA. Translation: AAC49779.1.
CU329671 Genomic DNA. Translation: CAA21260.1.
PIRiT39978.
RefSeqiNP_001018819.2. NM_001021982.3.

Genome annotation databases

EnsemblFungiiSPBC25B2.02c.1; SPBC25B2.02c.1:pep; SPBC25B2.02c.
GeneIDi2540405.
KEGGispo:SPBC25B2.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66305 Genomic DNA. Translation: AAC49779.1.
CU329671 Genomic DNA. Translation: CAA21260.1.
PIRiT39978.
RefSeqiNP_001018819.2. NM_001021982.3.

3D structure databases

ProteinModelPortaliP78966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4691729.

Protein family/group databases

TCDBi3.A.1.206.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

MaxQBiP78966.
PRIDEiP78966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC25B2.02c.1; SPBC25B2.02c.1:pep; SPBC25B2.02c.
GeneIDi2540405.
KEGGispo:SPBC25B2.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC25B2.02c.
PomBaseiSPBC25B2.02c. mam1.

Phylogenomic databases

InParanoidiP78966.
KOiK05658.
OMAiDTVKCLN.
OrthoDBiEOG092C02C4.
PhylomeDBiP78966.

Miscellaneous databases

PROiP78966.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 3 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAM1_SCHPO
AccessioniPrimary (citable) accession number: P78966
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1997
Last modified: October 5, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.