UniProtKB - P78963 (SKB1_SCHPO)
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Protein
Protein arginine N-methyltransferase skb1
Gene
skb1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that can catalyze both the mono- and symmetric (type II) dimethylation of the guanidino nitrogens of arginine residues in target proteins (By similarity). Positively modulates the shk1 kinase function. May be a mediator of hyperosmotic stress response (PubMed:11278267).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 316 | S-adenosyl-L-methionineBy similarity | 1 | |
Sitei | 319 | Critical for specifying symmetric addition of methyl groupsBy similarity | 1 | |
Binding sitei | 379 | S-adenosyl-L-methionineBy similarity | 1 | |
Active sitei | 422 | Proton donor/acceptorBy similarity | 1 | |
Active sitei | 431 | Proton donor/acceptorBy similarity | 1 |
GO - Molecular functioni
- histone-arginine N-methyltransferase activity Source: GO_Central
- protein-arginine N-methyltransferase activity Source: PomBase
GO - Biological processi
- cellular response to osmotic stress Source: PomBase
- establishment or maintenance of bipolar cell polarity regulating cell shape Source: PomBase
- lateral cortical node assembly Source: PomBase
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine Source: GO_Central
- peptidyl-arginine N-methylation Source: PomBase
- protein localization to lateral cortical node Source: PomBase
- regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Source: PomBase
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Protein arginine N-methyltransferase skb11 Publication (EC:2.1.1.-By similarity)Alternative name(s): Shk1 kinase-binding protein 11 Publication Type II protein arginine N-methyltransferaseBy similarity Short name: Type II PRMTBy similarity |
Gene namesi | ORF Names:SPBC16H5.11cImported |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC16H5.11c |
PomBasei | SPBC16H5.11c skb1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212346 | 1 – 645 | Protein arginine N-methyltransferase skb1Add BLAST | 645 |
Proteomic databases
MaxQBi | P78963 |
PaxDbi | P78963 |
PRIDEi | P78963 |
Interactioni
Subunit structurei
Interacts with the N-terminal regulatory domain of shk1. Shk1, cdc42 and skb1 are able to form a ternary complex in vivo.1 Publication
Protein-protein interaction databases
BioGridi | 27663737 interactors. |
IntActi | P78963 1 interactor. |
STRINGi | 4896.SPBC16H5.11c.1 |
Structurei
3D structure databases
ProteinModelPortali | P78963 |
SMRi | P78963 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 300 – 608 | SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST | 309 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 325 – 326 | S-adenosyl-L-methionine bindingBy similarity | 2 | |
Regioni | 406 – 407 | S-adenosyl-L-methionine bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation
Phylogenomic databases
HOGENOMi | HOG000175933 |
InParanoidi | P78963 |
KOi | K02516 |
OMAi | FPMFFPT |
OrthoDBi | EOG092C0SQ8 |
PhylomeDBi | P78963 |
Family and domain databases
InterProi | View protein in InterPro IPR025799 Arg_MeTrfase IPR007857 Arg_MeTrfase_PRMT5 IPR035075 PRMT5 IPR035248 PRMT5_C IPR035247 PRMT5_TIM IPR029063 SAM-dependent_MTases |
PANTHERi | PTHR10738 PTHR10738, 1 hit |
Pfami | View protein in Pfam PF05185 PRMT5, 1 hit PF17286 PRMT5_C, 1 hit PF17285 PRMT5_TIM, 1 hit |
PIRSFi | PIRSF015894 Skb1_MeTrfase, 1 hit |
SUPFAMi | SSF53335 SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678 SAM_MT_PRMT, 1 hit |
i Sequence
Sequence statusi: Complete.
P78963-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLRDGRIPQ YSIYPLPVPP MNSKTPTLGI VCSEGTISLS LEEGFEFVGV
60 70 80 90 100
PLSGEGLKLR VEALAPSERL QEFLDDEVAY HPEENVHKVV GLSSAWLELD
110 120 130 140 150
SEDTLIADRS EEVLLKEASY ASYCGLSSII LNGPTSPMNV MRYARAVSSA
160 170 180 190 200
LNSTMNLKFL VQLAIESGHE DYFETWKMWD TIRSACGYHP RLKVALELPP
210 220 230 240 250
ACSPPIELVN RWYAEPIEMI TMSCMAFVPN PNGYPVLGRK LRAIYALYLR
260 270 280 290 300
LNPRILLWDN DAPEKIGDSP DYSIYMKHLF DSQPPAPLVE DLADSYKDYL
310 320 330 340 350
QVPLQPLSYN LENITYEIFE RDPVKYAQYE QAIFSALMDR DESSVTRIAV
360 370 380 390 400
VGAGRGPLVD CALRAAISSS RTVDMIALEK NPNAFSMLLM RNRQDWAGKV
410 420 430 440 450
TLVFGDMRTW NPDYKIDILV SELLGSMGDN ELSPECLDGV QHVLDEETGI
460 470 480 490 500
CIPSSYISYV TPIMSPKLWS EARNMNDPNA FERQYVVLMN SFDFLAADDE
510 520 530 540 550
FRFQSLWSFH HPNKDSEVYT KNLHNKRFAS VRFQASSPGI LHGFAGYFEA
560 570 580 590 600
TLYKDISLSI MPATMEAKSP DMFSWFPIYM PIKKPMYVPE NSQLEFHMWR
610 620 630 640
LTDGMRVWFE WCANAYLVLR NGSQIKLSST EVHNISGKAF SCNMY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 45 | F → L in AAC49571 (PubMed:8943016).Curated | 1 | |
Sequence conflicti | 134 – 138 | PTSPM → SNFTQC in AAC49571 (PubMed:8943016).Curated | 5 | |
Sequence conflicti | 195 | A → G in AAC49571 (PubMed:8943016).Curated | 1 | |
Sequence conflicti | 398 | G → A in AAC49571 (PubMed:8943016).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U59684 Genomic DNA Translation: AAC49571.1 CU329671 Genomic DNA Translation: CAA17909.1 |
PIRi | T39614 T48644 |
RefSeqi | NP_595936.1, NM_001021844.2 |
Genome annotation databases
EnsemblFungii | SPBC16H5.11c.1; SPBC16H5.11c.1:pep; SPBC16H5.11c |
GeneIDi | 2540099 |
KEGGi | spo:SPBC16H5.11c |
Similar proteinsi
Entry informationi
Entry namei | SKB1_SCHPO | |
Accessioni | P78963Primary (citable) accession number: P78963 Secondary accession number(s): O42946 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 11, 2001 | |
Last modified: | March 28, 2018 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |