Reviewed,
UniProtKB/Swiss-Prot P78958 (G3P1_SCHPO)
Last modified
June 16, 2009.
Version 72.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glyceraldehyde-3-phosphate dehydrogenase 1 Short name=GAPDH 1 EC=1.2.1.12 | ||||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4896 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 336 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH. |
| Pathway | Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 336 | 336 | Glyceraldehyde-3-phosphate dehydrogenase 1 | PRO_0000145580 | |||||
Regions | |||||||||
| Nucleotide binding | 13 – 14 | 2 | NAD By similarity | ||||||
| Region | 151 – 153 | 3 | Glyceraldehyde 3-phosphate binding By similarity | ||||||
| Region | 211 – 212 | 2 | Glyceraldehyde 3-phosphate binding By similarity | ||||||
Sites | |||||||||
| Active site | 152 | 1 | Nucleophile By similarity | ||||||
| Binding site | 35 | 1 | NAD By similarity | ||||||
| Binding site | 80 | 1 | NAD; via carbonyl oxygen By similarity | ||||||
| Binding site | 182 | 1 | Glyceraldehyde 3-phosphate By similarity | ||||||
| Binding site | 234 | 1 | Glyceraldehyde 3-phosphate By similarity | ||||||
| Binding site | 316 | 1 | NAD By similarity | ||||||
| Site | 179 | 1 | Activates thiol group during catalysis By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 59 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 125 | 1 | Phosphoserine Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Orlandi I., Popolo L., Cavadini P., Vai M. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [3] | "Phosphoproteome analysis of fission yeast." Wilson-Grady J.T., Villen J., Gygi S.P. J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-125, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| X85332 mRNA. Translation: CAA59681.1. CU329671 Genomic DNA. Translation: CAA19372.1. | |
| PIR | T40235. |
| RefSeq | NP_596154.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1DSS based on UniProtKB P56649. |
| SMR | P78958. Positions 5-335. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P78958. 2 interactions. |
Genome annotation databases | |
| GeneID | 2540547. |
| KEGG | spo:SPBC32F12.11. |
| NMPDR | fig|4896.1.peg.2020. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC32F12.11. |
Phylogenomic databases | |
| OMA | P78958. RLELECH. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-004190-MON. |
| BRENDA | 1.2.1.12. 653. |
Gene expression databases | |
| ArrayExpress | P78958. |
Family and domain databases | |
| InterPro | IPR000173. GlycerAld_3-P_DH. IPR006424. Glyceraldehyde-3-P_DH_1. [Graphical view] |
| PANTHER | PTHR10836. GAP_DH. 1 hit. |
| Pfam | PF02800. Gp_dh_C. 1 hit. PF00044. Gp_dh_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000149. GAP_DH. 1 hit. |
| PRINTS | PR00078. G3PDHDRGNASE. |
| TIGRFAMs | TIGR01534. GAPDH-I. 1 hit. |
| PROSITE | PS00071. GAPDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | G3P1_SCHPO | ||||||||
| Accession | Primary (citable) accession number: P78958 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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