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Protein

Cofilin

Gene

cof1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cofilin
Alternative name(s):
Actin-depolymerizing factor 1
Gene namesi
Name:cof1
Synonyms:adf1
ORF Names:SPAC20G4.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G4.06c.
PomBaseiSPAC20G4.06c.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • nuclear matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137CofilinPRO_0000214914Add
BLAST

Proteomic databases

MaxQBiP78929.

PTM databases

SwissPalmiP78929.

Interactioni

Protein-protein interaction databases

BioGridi278232. 15 interactions.
MINTiMINT-4691589.

Structurei

Secondary structure

1
137
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2112Combined sources
Beta strandi26 – 327Combined sources
Beta strandi36 – 4510Combined sources
Helixi50 – 556Combined sources
Beta strandi59 – 613Combined sources
Beta strandi63 – 719Combined sources
Beta strandi73 – 764Combined sources
Beta strandi78 – 869Combined sources
Helixi93 – 10715Combined sources
Beta strandi115 – 1195Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I2QX-ray1.72A1-137[»]
ProteinModelPortaliP78929.
SMRiP78929. Positions 2-123.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78929.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 135131ADF-HPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated
Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000039697.
InParanoidiP78929.
KOiK05765.
OMAiKHEYQAN.
OrthoDBiEOG092C589Z.
PhylomeDBiP78929.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSGVKVSP ECLEAFQELK LGKSLRYVVF KMNDTKTEIV VEKKSTDKDF
60 70 80 90 100
DTFLGDLPEK DCRYAIYDFE FNLGEGVRNK IIFISWSPDV APIKSKMVYS
110 120 130
SSKDTLRRAF TGIGTDIQAT DFSEVAYETV LEKVTRK
Length:137
Mass (Da):15,620
Last modified:May 1, 1997 - v1
Checksum:iECC6D3354C959E04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89939 mRNA. Translation: BAA14039.1.
CU329670 Genomic DNA. Translation: CAB11258.1.
PIRiT43245.
RefSeqiNP_594741.1. NM_001020169.2.

Genome annotation databases

EnsemblFungiiSPAC20G4.06c.1; SPAC20G4.06c.1:pep; SPAC20G4.06c.
GeneIDi2541738.
KEGGispo:SPAC20G4.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89939 mRNA. Translation: BAA14039.1.
CU329670 Genomic DNA. Translation: CAB11258.1.
PIRiT43245.
RefSeqiNP_594741.1. NM_001020169.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2I2QX-ray1.72A1-137[»]
ProteinModelPortaliP78929.
SMRiP78929. Positions 2-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278232. 15 interactions.
MINTiMINT-4691589.

PTM databases

SwissPalmiP78929.

Proteomic databases

MaxQBiP78929.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC20G4.06c.1; SPAC20G4.06c.1:pep; SPAC20G4.06c.
GeneIDi2541738.
KEGGispo:SPAC20G4.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC20G4.06c.
PomBaseiSPAC20G4.06c.

Phylogenomic databases

HOGENOMiHOG000039697.
InParanoidiP78929.
KOiK05765.
OMAiKHEYQAN.
OrthoDBiEOG092C589Z.
PhylomeDBiP78929.

Miscellaneous databases

EvolutionaryTraceiP78929.
PROiP78929.

Family and domain databases

CDDicd11286. ADF_cofilin_like. 1 hit.
Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR017904. ADF/Cofilin.
[Graphical view]
PANTHERiPTHR11913. PTHR11913. 1 hit.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSiPR00006. COFILIN.
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOFI_SCHPO
AccessioniPrimary (citable) accession number: P78929
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.