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Protein

Cofilin

Gene

cof1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton.1 Publication

GO - Molecular functioni

  • actin filament binding Source: PomBase
  • actin monomer binding Source: PomBase

GO - Biological processi

  • actin filament debranching Source: PomBase
  • actin filament depolymerization Source: InterPro
  • actin filament severing Source: PomBase
  • actin nucleation Source: PomBase
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • negative regulation of actin filament binding Source: PomBase

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cofilin
Alternative name(s):
Actin-depolymerizing factor 1
Gene namesi
Name:cof1
Synonyms:adf1
ORF Names:SPAC20G4.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G4.06c
PomBaseiSPAC20G4.06c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002149141 – 137CofilinAdd BLAST137

Proteomic databases

MaxQBiP78929
PaxDbiP78929
PRIDEiP78929

PTM databases

iPTMnetiP78929
SwissPalmiP78929

Interactioni

GO - Molecular functioni

  • actin filament binding Source: PomBase
  • actin monomer binding Source: PomBase

Protein-protein interaction databases

BioGridi278232, 15 interactors
STRINGi4896.SPAC20G4.06c.1

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 21Combined sources12
Beta strandi26 – 32Combined sources7
Beta strandi36 – 45Combined sources10
Helixi50 – 55Combined sources6
Beta strandi59 – 61Combined sources3
Beta strandi63 – 71Combined sources9
Beta strandi73 – 76Combined sources4
Beta strandi78 – 86Combined sources9
Helixi93 – 107Combined sources15
Beta strandi115 – 119Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I2QX-ray1.72A1-137[»]
ProteinModelPortaliP78929
SMRiP78929
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP78929

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 135ADF-HPROSITE-ProRule annotationAdd BLAST131

Sequence similaritiesi

Belongs to the actin-binding proteins ADF family.Curated

Phylogenomic databases

HOGENOMiHOG000039697
InParanoidiP78929
KOiK05765
OMAiGLYDATY
OrthoDBiEOG092C589Z
PhylomeDBiP78929

Family and domain databases

CDDicd11286 ADF_cofilin_like, 1 hit
Gene3Di3.40.20.10, 1 hit
InterProiView protein in InterPro
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin
PANTHERiPTHR11913 PTHR11913, 1 hit
PfamiView protein in Pfam
PF00241 Cofilin_ADF, 1 hit
PRINTSiPR00006 COFILIN
SMARTiView protein in SMART
SM00102 ADF, 1 hit
PROSITEiView protein in PROSITE
PS51263 ADF_H, 1 hit

Sequencei

Sequence statusi: Complete.

P78929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFSGVKVSP ECLEAFQELK LGKSLRYVVF KMNDTKTEIV VEKKSTDKDF
60 70 80 90 100
DTFLGDLPEK DCRYAIYDFE FNLGEGVRNK IIFISWSPDV APIKSKMVYS
110 120 130
SSKDTLRRAF TGIGTDIQAT DFSEVAYETV LEKVTRK
Length:137
Mass (Da):15,620
Last modified:May 1, 1997 - v1
Checksum:iECC6D3354C959E04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89939 mRNA Translation: BAA14039.1
CU329670 Genomic DNA Translation: CAB11258.1
PIRiT43245
RefSeqiNP_594741.1, NM_001020169.2

Genome annotation databases

EnsemblFungiiSPAC20G4.06c.1; SPAC20G4.06c.1:pep; SPAC20G4.06c
GeneIDi2541738
KEGGispo:SPAC20G4.06c

Similar proteinsi

Entry informationi

Entry nameiCOFI_SCHPO
AccessioniPrimary (citable) accession number: P78929
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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