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Protein

Probable T-complex protein 1 subunit theta

Gene

cct8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-6798695 Neutrophil degranulation
R-SPO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable T-complex protein 1 subunit theta
Short name:
TCP-1-theta
Alternative name(s):
CCT-theta
Gene namesi
Name:cct8
ORF Names:SPBC337.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC337.05c
PomBaseiSPBC337.05c cct8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283771 – 546Probable T-complex protein 1 subunit thetaAdd BLAST546

Proteomic databases

MaxQBiP78921
PaxDbiP78921
PRIDEiP78921

PTM databases

iPTMnetiP78921

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276835, 4 interactors
IntActiP78921, 1 interactor
STRINGi4896.SPBC337.05c.1

Structurei

3D structure databases

ProteinModelPortaliP78921
SMRiP78921
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

HOGENOMiHOG000226734
InParanoidiP78921
KOiK09500
OMAiWGLKYAV
OrthoDBiEOG092C2629
PhylomeDBiP78921

Family and domain databases

CDDicd03341 TCP1_theta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012721 Chap_CCT_theta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02346 chap_CCT_theta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P78921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVPKASG PQLFREGYRI MQGVEDAVIR NCNAIRELSE ITRTSLGPNG
60 70 80 90 100
KNKIVVNHLQ QTFLTNDAAT IIRELEVIHP AAKLVVDATQ QQENELGDAA
110 120 130 140 150
NFVVVFTGEL LAKAENMIRM GLTPLEIAKG YEMALSHTME VLEEICADKI
160 170 180 190 200
ETVESEKELI KAIRTCISSK QYGNEDFLSD LVAKAILTVL PKDPSKFNVD
210 220 230 240 250
NIRVVKIMGS SLYNSQVVKG MVFPREPEGT VTRSKEAKVA VFSCPLDISQ
260 270 280 290 300
TETKGTVLLH NAQEMLDFSK GEENLIESHI KEIYDAGVRV VVTSGNVNDL
310 320 330 340 350
VLHYLNRFEI LVIRVPSKFE LRRLCRVVGA TPLARMGVPM PEEMGSVDVV
360 370 380 390 400
ETIEIGGDRV TVFRQVEDIT RTATIVLRGA TKTYLDDLER AIDDGVNIVK
410 420 430 440 450
ALVKDNRLIF GAGASDMQLC IRLISVGEKT PGIYQHAIKQ YGEAFEVVPR
460 470 480 490 500
TISENAGLDP TDVISKLYAA HHKENGESIG VDVECENDGT LDAKEAGIFD
510 520 530 540
VLLAKKSAIR LATETVLTVL NVDQVVMSKP AGGPKPPGPN PHWDDD
Length:546
Mass (Da):59,956
Last modified:December 1, 2000 - v3
Checksum:i61EEBF8CE3A4ACEE
GO

Sequence cautioni

The sequence BAA13933 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104V → I in BAA13933 (PubMed:9501991).Curated1
Sequence conflicti107 – 112TGELLA → SGALLL in BAA13933 (PubMed:9501991).Curated6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89272 mRNA Translation: BAA13933.1 Different initiation.
CU329671 Genomic DNA Translation: CAA21275.1
PIRiT40258
T43202
RefSeqiNP_595406.1, NM_001021313.2

Genome annotation databases

EnsemblFungiiSPBC337.05c.1; SPBC337.05c.1:pep; SPBC337.05c
GeneIDi2540305
KEGGispo:SPBC337.05c

Similar proteinsi

Entry informationi

Entry nameiTCPQ_SCHPO
AccessioniPrimary (citable) accession number: P78921
Secondary accession number(s): O74816
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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