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P78917

- G6PI_SCHPO

UniProt

P78917 - G6PI_SCHPO

Protein

Glucose-6-phosphate isomerase

Gene

pgi1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei363 – 3631Proton donorBy similarity
    Active sitei394 – 3941By similarity
    Active sitei516 – 5161By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: PomBase

    GO - Biological processi

    1. gluconeogenesis Source: PomBase
    2. glycolytic process Source: PomBase
    3. pentose-phosphate shunt Source: PomBase

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    ReactomeiREACT_218730. Gluconeogenesis.
    REACT_227920. Glycolysis.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi1
    ORF Names:SPBC1604.05
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome II

    Organism-specific databases

    PomBaseiSPBC1604.05.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Glucose-6-phosphate isomerasePRO_0000180577Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei455 – 4551Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP78917.
    PaxDbiP78917.

    Interactioni

    Protein-protein interaction databases

    BioGridi276182. 4 interactions.
    MINTiMINT-4691541.
    STRINGi4896.SPBC1604.05-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP78917.
    SMRiP78917. Positions 7-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiMIALTHY.
    OrthoDBiEOG7N0CDV.
    PhylomeDBiP78917.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P78917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFSLASTLP AWQAVQTHYE SVGKHLVLKE LFAKDSSRFE KFSFTFNGLK    50
    EEDGPILFDF SKNLITEETV ELLVKLAKEA NVEGLRDALF AGEHINFTED 100
    RAVFHPALRN VSEKPMKVNG QDVMPGVRKV LRHMKEFSDA VRSGAWKGYT 150
    GKPIKSIVNV GIGGSDLGPV MVTEALKPYG QENLELHFVS NIDGTHLAEA 200
    LKKCDPETTL FLIASKTFTT AETCTNAKSA KDWFLASAKD PSHVAKHFVA 250
    LSTNEKEVTA FGISAQNMFE FSDWVGGRYS VWSAIGLSVA LYIGYENFEA 300
    FLSGAHAMDE YFCSTPLEKN IPALAALISI WYSDFFGAQT HLVAPYDQYL 350
    HRFPAYLQQL SMESNGKAIT RSGDMVNYTT GKILWGEPGT NSQHSFFQLI 400
    HQGTKLIPAD FLIPIESHNP IDNNKHHRML FSNFAAQTEA LMLGKTPAEV 450
    KAEGTPDEIV PHKTFVGNRP SNSIIAKKIT PASLGALIAF YEWVTFTEGA 500
    VWNINSFDQF GVELGKKLAK NVLAQLETKG DVENHDSSTN GLINLFKNGF 550
    Length:550
    Mass (Da):60,884
    Last modified:May 30, 2000 - v2
    Checksum:iD882FC8D6C64B793
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41S → C in BAA13929. (PubMed:9501991)Curated
    Sequence conflicti13 – 142QA → EV in BAA13929. (PubMed:9501991)Curated
    Sequence conflicti168 – 1681G → A in BAA13929. (PubMed:9501991)Curated
    Sequence conflicti198 – 1981A → S in BAA13929. (PubMed:9501991)Curated
    Sequence conflicti519 – 5191A → V in BAA13929. (PubMed:9501991)Curated
    Sequence conflicti536 – 5361D → Y in BAA13929. (PubMed:9501991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89268 mRNA. Translation: BAA13929.1.
    CU329671 Genomic DNA. Translation: CAA22338.1.
    PIRiT39509.
    T43196.
    RefSeqiNP_596635.1. NM_001022556.2.

    Genome annotation databases

    EnsemblFungiiSPBC1604.05.1; SPBC1604.05.1:pep; SPBC1604.05.
    GeneIDi2539625.
    KEGGispo:SPBC1604.05.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D89268 mRNA. Translation: BAA13929.1 .
    CU329671 Genomic DNA. Translation: CAA22338.1 .
    PIRi T39509.
    T43196.
    RefSeqi NP_596635.1. NM_001022556.2.

    3D structure databases

    ProteinModelPortali P78917.
    SMRi P78917. Positions 7-548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276182. 4 interactions.
    MINTi MINT-4691541.
    STRINGi 4896.SPBC1604.05-1.

    Proteomic databases

    MaxQBi P78917.
    PaxDbi P78917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPBC1604.05.1 ; SPBC1604.05.1:pep ; SPBC1604.05 .
    GeneIDi 2539625.
    KEGGi spo:SPBC1604.05.

    Organism-specific databases

    PomBasei SPBC1604.05.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi MIALTHY.
    OrthoDBi EOG7N0CDV.
    PhylomeDBi P78917.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    Reactomei REACT_218730. Gluconeogenesis.
    REACT_227920. Glycolysis.

    Miscellaneous databases

    NextBioi 20800781.
    PROi P78917.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: PR745.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-455, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiG6PI_SCHPO
    AccessioniPrimary (citable) accession number: P78917
    Secondary accession number(s): O94371
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3