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P78917 (G6PI_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi1
ORF Names:SPBC1604.05
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

glycolysis

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

pentose-phosphate shunt

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Cellular componentcytosol

Inferred from direct assay. Source: GeneDB_Spombe

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Glucose-6-phosphate isomerase
PRO_0000180577

Sites

Active site3631Proton donor By similarity
Active site3941 By similarity
Active site5161 By similarity

Amino acid modifications

Modified residue4551Phosphothreonine Ref.3

Experimental info

Sequence conflict41S → C in BAA13929. Ref.1
Sequence conflict13 – 142QA → EV in BAA13929. Ref.1
Sequence conflict1681G → A in BAA13929. Ref.1
Sequence conflict1981A → S in BAA13929. Ref.1
Sequence conflict5191A → V in BAA13929. Ref.1
Sequence conflict5361D → Y in BAA13929. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P78917 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: D882FC8D6C64B793

FASTA55060,884
        10         20         30         40         50         60 
MSFSLASTLP AWQAVQTHYE SVGKHLVLKE LFAKDSSRFE KFSFTFNGLK EEDGPILFDF 

        70         80         90        100        110        120 
SKNLITEETV ELLVKLAKEA NVEGLRDALF AGEHINFTED RAVFHPALRN VSEKPMKVNG 

       130        140        150        160        170        180 
QDVMPGVRKV LRHMKEFSDA VRSGAWKGYT GKPIKSIVNV GIGGSDLGPV MVTEALKPYG 

       190        200        210        220        230        240 
QENLELHFVS NIDGTHLAEA LKKCDPETTL FLIASKTFTT AETCTNAKSA KDWFLASAKD 

       250        260        270        280        290        300 
PSHVAKHFVA LSTNEKEVTA FGISAQNMFE FSDWVGGRYS VWSAIGLSVA LYIGYENFEA 

       310        320        330        340        350        360 
FLSGAHAMDE YFCSTPLEKN IPALAALISI WYSDFFGAQT HLVAPYDQYL HRFPAYLQQL 

       370        380        390        400        410        420 
SMESNGKAIT RSGDMVNYTT GKILWGEPGT NSQHSFFQLI HQGTKLIPAD FLIPIESHNP 

       430        440        450        460        470        480 
IDNNKHHRML FSNFAAQTEA LMLGKTPAEV KAEGTPDEIV PHKTFVGNRP SNSIIAKKIT 

       490        500        510        520        530        540 
PASLGALIAF YEWVTFTEGA VWNINSFDQF GVELGKKLAK NVLAQLETKG DVENHDSSTN 

       550 
GLINLFKNGF

« Hide

References

[1]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: PR745.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-455, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D89268 mRNA. Translation: BAA13929.1.
CU329671 Genomic DNA. Translation: CAA22338.1.
PIRT39509.
T43196.
RefSeqNP_596635.1. NM_001022556.1.

3D structure databases

ProteinModelPortalP78917.
SMRP78917. Positions 7-548.
ModBaseSearch...

Protein-protein interaction databases

STRINGP78917.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1604.05.1; SPBC1604.05.1:pep; SPBC1604.05.
GeneID2539625.
GenomeReviewsGene locus pgi1 in contig CU329671_GR.
KEGGspo:SPBC1604.05.
NMPDRfig|4896.1.peg.2501.

Organism-specific databases

GeneDB_SpombeSPBC1604.05.

Phylogenomic databases

eggNOGfuNOG04321.
GeneTreeEFGT00050000004334.
HOGENOMHBG352954.
OMANSLPAWT.
OrthoDBEOG43NBN0.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004624-MONOMER.

Gene expression databases

ArrayExpressP78917.

Family and domain databases

InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
Gene3DG3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_SCHPO
AccessionPrimary (citable) accession number: P78917
Secondary accession number(s): O94371
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: December 14, 2011
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents