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P78917

- G6PI_SCHPO

UniProt

P78917 - G6PI_SCHPO

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Protein

Glucose-6-phosphate isomerase

Gene

pgi1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei363 – 3631Proton donorBy similarity
Active sitei394 – 3941By similarity
Active sitei516 – 5161By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: PomBase

GO - Biological processi

  1. canonical glycolysis Source: PomBase
  2. gluconeogenesis Source: PomBase
  3. pentose-phosphate shunt Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

ReactomeiREACT_218730. Gluconeogenesis.
REACT_227920. Glycolysis.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi1
ORF Names:SPBC1604.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC1604.05.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Glucose-6-phosphate isomerasePRO_0000180577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei455 – 4551Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78917.
PaxDbiP78917.

Interactioni

Protein-protein interaction databases

BioGridi276182. 4 interactions.
MINTiMINT-4691541.
STRINGi4896.SPBC1604.05-1.

Structurei

3D structure databases

ProteinModelPortaliP78917.
SMRiP78917. Positions 7-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
InParanoidiP78917.
KOiK01810.
OMAiMIALTHY.
OrthoDBiEOG7N0CDV.
PhylomeDBiP78917.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78917-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFSLASTLP AWQAVQTHYE SVGKHLVLKE LFAKDSSRFE KFSFTFNGLK
60 70 80 90 100
EEDGPILFDF SKNLITEETV ELLVKLAKEA NVEGLRDALF AGEHINFTED
110 120 130 140 150
RAVFHPALRN VSEKPMKVNG QDVMPGVRKV LRHMKEFSDA VRSGAWKGYT
160 170 180 190 200
GKPIKSIVNV GIGGSDLGPV MVTEALKPYG QENLELHFVS NIDGTHLAEA
210 220 230 240 250
LKKCDPETTL FLIASKTFTT AETCTNAKSA KDWFLASAKD PSHVAKHFVA
260 270 280 290 300
LSTNEKEVTA FGISAQNMFE FSDWVGGRYS VWSAIGLSVA LYIGYENFEA
310 320 330 340 350
FLSGAHAMDE YFCSTPLEKN IPALAALISI WYSDFFGAQT HLVAPYDQYL
360 370 380 390 400
HRFPAYLQQL SMESNGKAIT RSGDMVNYTT GKILWGEPGT NSQHSFFQLI
410 420 430 440 450
HQGTKLIPAD FLIPIESHNP IDNNKHHRML FSNFAAQTEA LMLGKTPAEV
460 470 480 490 500
KAEGTPDEIV PHKTFVGNRP SNSIIAKKIT PASLGALIAF YEWVTFTEGA
510 520 530 540 550
VWNINSFDQF GVELGKKLAK NVLAQLETKG DVENHDSSTN GLINLFKNGF
Length:550
Mass (Da):60,884
Last modified:May 30, 2000 - v2
Checksum:iD882FC8D6C64B793
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41S → C in BAA13929. (PubMed:9501991)Curated
Sequence conflicti13 – 142QA → EV in BAA13929. (PubMed:9501991)Curated
Sequence conflicti168 – 1681G → A in BAA13929. (PubMed:9501991)Curated
Sequence conflicti198 – 1981A → S in BAA13929. (PubMed:9501991)Curated
Sequence conflicti519 – 5191A → V in BAA13929. (PubMed:9501991)Curated
Sequence conflicti536 – 5361D → Y in BAA13929. (PubMed:9501991)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89268 mRNA. Translation: BAA13929.1.
CU329671 Genomic DNA. Translation: CAA22338.1.
PIRiT39509.
T43196.
RefSeqiNP_596635.1. NM_001022556.2.

Genome annotation databases

EnsemblFungiiSPBC1604.05.1; SPBC1604.05.1:pep; SPBC1604.05.
GeneIDi2539625.
KEGGispo:SPBC1604.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D89268 mRNA. Translation: BAA13929.1 .
CU329671 Genomic DNA. Translation: CAA22338.1 .
PIRi T39509.
T43196.
RefSeqi NP_596635.1. NM_001022556.2.

3D structure databases

ProteinModelPortali P78917.
SMRi P78917. Positions 7-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276182. 4 interactions.
MINTi MINT-4691541.
STRINGi 4896.SPBC1604.05-1.

Proteomic databases

MaxQBi P78917.
PaxDbi P78917.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC1604.05.1 ; SPBC1604.05.1:pep ; SPBC1604.05 .
GeneIDi 2539625.
KEGGi spo:SPBC1604.05.

Organism-specific databases

PomBasei SPBC1604.05.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261371.
InParanoidi P78917.
KOi K01810.
OMAi MIALTHY.
OrthoDBi EOG7N0CDV.
PhylomeDBi P78917.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
Reactomei REACT_218730. Gluconeogenesis.
REACT_227920. Glycolysis.

Miscellaneous databases

NextBioi 20800781.
PROi P78917.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: PR745.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-455, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiG6PI_SCHPO
AccessioniPrimary (citable) accession number: P78917
Secondary accession number(s): O94371
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 30, 2000
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3