Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable lipase C16A3.12c

Gene

SPBC16A3.12c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable lipase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210NucleophileBy similarity1
Active sitei378Charge relay systemBy similarity1
Active sitei404Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-SPO-192456. Digestion of dietary lipid.

Protein family/group databases

ESTHERischpo-SPBC16A3.12C. Acidic_Lipase.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipase C16A3.12c (EC:3.1.1.-)
Gene namesi
ORF Names:SPBC16A3.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16A3.12c.
PomBaseiSPBC16A3.12c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini38 – 443LumenalSequence analysisAdd BLAST406

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • fungal-type vacuole Source: PomBase
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126601 – 443Probable lipase C16A3.12cAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi177N-linked (GlcNAc...)Sequence analysis1
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Glycosylationi335N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP78898.
PRIDEiP78898.

Interactioni

Protein-protein interaction databases

BioGridi276421. 5 interactors.
MINTiMINT-4691533.

Structurei

3D structure databases

ProteinModelPortaliP78898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 410AB hydrolase-1Sequence analysisAdd BLAST295

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000173756.
InParanoidiP78898.
OrthoDBiEOG092C1FMW.
PhylomeDBiP78898.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

P78898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFNKNQIY WGDYVGVIAA FVGVYTELVA RIFIYMIPER VREWFRVRII
60 70 80 90 100
VLYHYYISSK TTDGMTDAVQ KCRNIYEICE AFGYRVEEHL VRTQDNFILC
110 120 130 140 150
LHRITHPKQS QHKREVVYCH HGLMTNSELW VAVNESERSL PFVLIESGYD
160 170 180 190 200
VWLGNNRGNK YSRKHITYKP KDEEFWNFSL DDMAMFDIPD TVDYILRETG
210 220 230 240 250
REKLNYIGFS QGTAQAMAAL SINPDLNDKV NIFIGLAPAY APKGFSNYFV
260 270 280 290 300
DYIVKVNPKI MYHLFGRRCL LPSVTFWQNI CYPPIFVKIV DVSLKILFNW
310 320 330 340 350
DLSNISLNQK LCGYAHLYSF SSVKSVVHWL QIIKNCTFQL YDDDMALLAG
360 370 380 390 400
YGSRHYQVPL FPTNNIKCPM LILWGGKDTL INMEVMRTAL PPHAKEVSIA
410 420 430 440
HYEHLDFLWG QDVKEEVFPV VIDALKHHSL GKAKHFVKQN GFH
Length:443
Mass (Da):51,548
Last modified:January 1, 1999 - v2
Checksum:i92ED3CBACFC42D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16863.1.
PIRiT39540.
T43170.
RefSeqiNP_596777.1. NM_001023798.2.

Genome annotation databases

EnsemblFungiiSPBC16A3.12c.1; SPBC16A3.12c.1:pep; SPBC16A3.12c.
GeneIDi2539875.
KEGGispo:SPBC16A3.12c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA16863.1.
PIRiT39540.
T43170.
RefSeqiNP_596777.1. NM_001023798.2.

3D structure databases

ProteinModelPortaliP78898.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276421. 5 interactors.
MINTiMINT-4691533.

Protein family/group databases

ESTHERischpo-SPBC16A3.12C. Acidic_Lipase.

Proteomic databases

MaxQBiP78898.
PRIDEiP78898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC16A3.12c.1; SPBC16A3.12c.1:pep; SPBC16A3.12c.
GeneIDi2539875.
KEGGispo:SPBC16A3.12c.

Organism-specific databases

EuPathDBiFungiDB:SPBC16A3.12c.
PomBaseiSPBC16A3.12c.

Phylogenomic databases

HOGENOMiHOG000173756.
InParanoidiP78898.
OrthoDBiEOG092C1FMW.
PhylomeDBiP78898.

Enzyme and pathway databases

ReactomeiR-SPO-192456. Digestion of dietary lipid.

Miscellaneous databases

PROiP78898.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR025483. Lipase_euk.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000862. Steryl_ester_lip. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTGCE2_SCHPO
AccessioniPrimary (citable) accession number: P78898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1999
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.