Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable lipase C16A3.12c

Gene

SPBC16A3.12c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable lipase.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei210NucleophileBy similarity1
Active sitei378Charge relay systemBy similarity1
Active sitei404Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-SPO-192456 Digestion of dietary lipid
R-SPO-6809371 Formation of the cornified envelope

Protein family/group databases

ESTHERischpo-SPBC16A3.12C Acidic_Lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipase C16A3.12c (EC:3.1.1.-)
Gene namesi
ORF Names:SPBC16A3.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC16A3.12c
PomBaseiSPBC16A3.12c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini38 – 443LumenalSequence analysisAdd BLAST406

Keywords - Cellular componenti

Cytoplasm, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126601 – 443Probable lipase C16A3.12cAdd BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi304N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP78898
PaxDbiP78898
PRIDEiP78898

Interactioni

Protein-protein interaction databases

BioGridi276421, 5 interactors
STRINGi4896.SPBC16A3.12c.1

Structurei

3D structure databases

ProteinModelPortaliP78898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 410AB hydrolase-1Sequence analysisAdd BLAST295

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000173756
InParanoidiP78898
OMAiPEWAHVD
OrthoDBiEOG092C1FMW
PhylomeDBiP78898

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR025483 Lipase_euk
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PIRSFiPIRSF000862 Steryl_ester_lip, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

P78898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFNKNQIY WGDYVGVIAA FVGVYTELVA RIFIYMIPER VREWFRVRII
60 70 80 90 100
VLYHYYISSK TTDGMTDAVQ KCRNIYEICE AFGYRVEEHL VRTQDNFILC
110 120 130 140 150
LHRITHPKQS QHKREVVYCH HGLMTNSELW VAVNESERSL PFVLIESGYD
160 170 180 190 200
VWLGNNRGNK YSRKHITYKP KDEEFWNFSL DDMAMFDIPD TVDYILRETG
210 220 230 240 250
REKLNYIGFS QGTAQAMAAL SINPDLNDKV NIFIGLAPAY APKGFSNYFV
260 270 280 290 300
DYIVKVNPKI MYHLFGRRCL LPSVTFWQNI CYPPIFVKIV DVSLKILFNW
310 320 330 340 350
DLSNISLNQK LCGYAHLYSF SSVKSVVHWL QIIKNCTFQL YDDDMALLAG
360 370 380 390 400
YGSRHYQVPL FPTNNIKCPM LILWGGKDTL INMEVMRTAL PPHAKEVSIA
410 420 430 440
HYEHLDFLWG QDVKEEVFPV VIDALKHHSL GKAKHFVKQN GFH
Length:443
Mass (Da):51,548
Last modified:January 1, 1999 - v2
Checksum:i92ED3CBACFC42D0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAA16863.1
PIRiT39540
T43170
RefSeqiNP_596777.1, NM_001023798.2

Genome annotation databases

EnsemblFungiiSPBC16A3.12c.1; SPBC16A3.12c.1:pep; SPBC16A3.12c
GeneIDi2539875
KEGGispo:SPBC16A3.12c

Similar proteinsi

Entry informationi

Entry nameiTGCE2_SCHPO
AccessioniPrimary (citable) accession number: P78898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: January 1, 1999
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health