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Protein

Trehalose-phosphatase

Gene

tpp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Trehalose 6-phosphate + H2O = trehalose + phosphate.

GO - Molecular functioni

  • trehalose-phosphatase activity Source: PomBase

GO - Biological processi

  • trehalose biosynthetic process Source: GO_Central
  • trehalose metabolic process Source: PomBase
  • trehalose metabolism in response to stress Source: GO_Central

Keywordsi

Molecular functionHydrolase

Protein family/group databases

CAZyiGT20 Glycosyltransferase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalose-phosphatase (EC:3.1.3.12)
Alternative name(s):
Trehalose-6-phosphate phosphatase
Short name:
TPP
Gene namesi
Name:tpp1
ORF Names:SPAC19G12.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC19G12.15c
PomBaseiSPAC19G12.15c tpp1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225081 – 817Trehalose-phosphataseAdd BLAST817

Proteomic databases

MaxQBiP78875
PaxDbiP78875
PRIDEiP78875

Interactioni

Protein-protein interaction databases

BioGridi279033, 73 interactors
STRINGi4896.SPAC19G12.15c.1

Structurei

3D structure databases

ProteinModelPortaliP78875
SMRiP78875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 547GlycosyltransferaseAdd BLAST547

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the trehalose phosphatase family.Curated

Phylogenomic databases

HOGENOMiHOG000191477
InParanoidiP78875
KOiK16055
OMAiENMLRMH
OrthoDBiEOG092C0LDC
PhylomeDBiP78875

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR036412 HAD-like_sf
IPR006379 HAD-SF_hydro_IIB
IPR023214 HAD_sf
IPR003337 Trehalose_PPase
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
PF02358 Trehalose_PPase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01484 HAD-SF-IIB, 1 hit
TIGR00685 T6PP, 1 hit

Sequencei

Sequence statusi: Complete.

P78875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYGKIPST SFEHENTFEL SGDLLDPEEL KSLGVSGRII YVLRHLPFKS
60 70 80 90 100
SINEETREWD LSGRRGATTM YSSMNWLANS TYWQTTLVGW TGVIPTVSEK
110 120 130 140 150
EENKDAVTRL DSQDVKRFEE TYSQWNSGER STEYVPVWLP GPEKGSETII
160 170 180 190 200
NETRSQQSRW LAYAENVIRP LIHYKYWPSS EVDENEEQWW RDYVKMNHAF
210 220 230 240 250
ADKICEIYKP GDFIIVQDYS LFLVPQLIRN KIDDAVIGFY HHHPFPSSEI
260 270 280 290 300
ARCFPRRRAI LRSVLGADFI GFEDYSYARH FISCCSRVLD LEIGHDWVNL
310 320 330 340 350
NGNKVTVRAI TVGIDVPRII RSSGNVSVSE KLEELNKRYE NMKVILGRDR
360 370 380 390 400
LDELYGVPQK LRSFQRFLRT YPEWRKKVVL IQITISSAFK HPKLLSSIKK
410 420 430 440 450
LVQAINQEFG TDDYTPVHHV EEQLEPADYF ALLTRADALF INSIREGVSN
460 470 480 490 500
LALEYVVCQR DRYGMVLLSE FTATSAMLHD VPLINPWDYN ECAEIISNAL
510 520 530 540 550
STPLERRKMI ERESYKQVTT HTMQSWTSSL IRSLANKLAA TKTDQRIPTL
560 570 580 590 600
TPEHALSVYS KASKRLFMMD YDGTLTPIVR DPNAAVPSKK LLDNLATLAA
610 620 630 640 650
DPKNQVWIIS GRDQQFLRNW MDDIKGLGLS AEHGSFVRKP HSTTWINLAE
660 670 680 690 700
LLDMSWKKEV RRIFQYYTDR TQGSSIEEKR CAMTWHYRKA DPENGAFQAL
710 720 730 740 750
ECEALLEELV CSKYDVEIMR GKANLEVRPS SINKGGIVKQ ILSSYPEDSL
760 770 780 790 800
PSFIFCAGDD RTDEDMFRSL HKNTRINKET SFAVTIGSDK KLSIADWCIA
810
DPANVIDILA DLANFTN
Length:817
Mass (Da):93,878
Last modified:May 1, 1999 - v2
Checksum:i23CFD2533505CCBA
GO

Sequence cautioni

The sequence AAL77573 differs from that shown. Reason: Frameshift at position 800.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124 – 135QWNSG…STEYV → GTRNGVRSR (Ref. 3) CuratedAdd BLAST12
Sequence conflicti279R → S in AAL77573 (Ref. 3) Curated1
Sequence conflicti494E → G in AAL77573 (Ref. 3) Curated1
Sequence conflicti498N → Y in AAL77573 (Ref. 3) Curated1
Sequence conflicti513E → A in AAL77573 (Ref. 3) Curated1
Sequence conflicti536N → Y in AAL77573 (Ref. 3) Curated1
Sequence conflicti693 – 696ENGA → REWS in AAL77573 (Ref. 3) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242743 Genomic DNA Translation: CAB45142.1
CU329670 Genomic DNA Translation: CAB10126.1
L40359 mRNA Translation: AAL77573.1 Frameshift.
D89225 mRNA Translation: BAA13886.1
PIRiT43659
RefSeqiNP_594430.1, NM_001019859.2

Genome annotation databases

EnsemblFungiiSPAC19G12.15c.1; SPAC19G12.15c.1:pep; SPAC19G12.15c
GeneIDi2542577
KEGGispo:SPAC19G12.15c

Similar proteinsi

Entry informationi

Entry nameiTPP1_SCHPO
AccessioniPrimary (citable) accession number: P78875
Secondary accession number(s): Q8TGH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health