Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Trehalose-phosphatase

Gene

tpp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Trehalose 6-phosphate + H2O = trehalose + phosphate.

GO - Molecular functioni

  • trehalose-phosphatase activity Source: PomBase

GO - Biological processi

  • dephosphorylation Source: GOC
  • trehalose biosynthetic process Source: InterPro
  • trehalose metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalose-phosphatase (EC:3.1.3.12)
Alternative name(s):
Trehalose-6-phosphate phosphatase
Short name:
TPP
Gene namesi
Name:tpp1
ORF Names:SPAC19G12.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC19G12.15c.
PomBaseiSPAC19G12.15c. tpp1.

Subcellular locationi

GO - Cellular componenti

  • alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817Trehalose-phosphatasePRO_0000122508Add
BLAST

Proteomic databases

MaxQBiP78875.

Interactioni

Protein-protein interaction databases

BioGridi279033. 73 interactions.

Structurei

3D structure databases

ProteinModelPortaliP78875.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 547547GlycosyltransferaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the trehalose phosphatase family.Curated

Phylogenomic databases

HOGENOMiHOG000191477.
InParanoidiP78875.
KOiK16055.
OMAiEPERFIN.
OrthoDBiEOG76QFS6.
PhylomeDBiP78875.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR003337. Trehalose_PPase.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
TIGR00685. T6PP. 1 hit.

Sequencei

Sequence statusi: Complete.

P78875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYGKIPST SFEHENTFEL SGDLLDPEEL KSLGVSGRII YVLRHLPFKS
60 70 80 90 100
SINEETREWD LSGRRGATTM YSSMNWLANS TYWQTTLVGW TGVIPTVSEK
110 120 130 140 150
EENKDAVTRL DSQDVKRFEE TYSQWNSGER STEYVPVWLP GPEKGSETII
160 170 180 190 200
NETRSQQSRW LAYAENVIRP LIHYKYWPSS EVDENEEQWW RDYVKMNHAF
210 220 230 240 250
ADKICEIYKP GDFIIVQDYS LFLVPQLIRN KIDDAVIGFY HHHPFPSSEI
260 270 280 290 300
ARCFPRRRAI LRSVLGADFI GFEDYSYARH FISCCSRVLD LEIGHDWVNL
310 320 330 340 350
NGNKVTVRAI TVGIDVPRII RSSGNVSVSE KLEELNKRYE NMKVILGRDR
360 370 380 390 400
LDELYGVPQK LRSFQRFLRT YPEWRKKVVL IQITISSAFK HPKLLSSIKK
410 420 430 440 450
LVQAINQEFG TDDYTPVHHV EEQLEPADYF ALLTRADALF INSIREGVSN
460 470 480 490 500
LALEYVVCQR DRYGMVLLSE FTATSAMLHD VPLINPWDYN ECAEIISNAL
510 520 530 540 550
STPLERRKMI ERESYKQVTT HTMQSWTSSL IRSLANKLAA TKTDQRIPTL
560 570 580 590 600
TPEHALSVYS KASKRLFMMD YDGTLTPIVR DPNAAVPSKK LLDNLATLAA
610 620 630 640 650
DPKNQVWIIS GRDQQFLRNW MDDIKGLGLS AEHGSFVRKP HSTTWINLAE
660 670 680 690 700
LLDMSWKKEV RRIFQYYTDR TQGSSIEEKR CAMTWHYRKA DPENGAFQAL
710 720 730 740 750
ECEALLEELV CSKYDVEIMR GKANLEVRPS SINKGGIVKQ ILSSYPEDSL
760 770 780 790 800
PSFIFCAGDD RTDEDMFRSL HKNTRINKET SFAVTIGSDK KLSIADWCIA
810
DPANVIDILA DLANFTN
Length:817
Mass (Da):93,878
Last modified:May 1, 1999 - v2
Checksum:i23CFD2533505CCBA
GO

Sequence cautioni

The sequence AAL77573.1 differs from that shown. Reason: Frameshift at position 800. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 13512QWNSG…STEYV → GTRNGVRSR (Ref. 3) CuratedAdd
BLAST
Sequence conflicti279 – 2791R → S in AAL77573 (Ref. 3) Curated
Sequence conflicti494 – 4941E → G in AAL77573 (Ref. 3) Curated
Sequence conflicti498 – 4981N → Y in AAL77573 (Ref. 3) Curated
Sequence conflicti513 – 5131E → A in AAL77573 (Ref. 3) Curated
Sequence conflicti536 – 5361N → Y in AAL77573 (Ref. 3) Curated
Sequence conflicti693 – 6964ENGA → REWS in AAL77573 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242743 Genomic DNA. Translation: CAB45142.1.
CU329670 Genomic DNA. Translation: CAB10126.1.
L40359 mRNA. Translation: AAL77573.1. Frameshift.
D89225 mRNA. Translation: BAA13886.1.
PIRiT43659.
RefSeqiNP_594430.1. NM_001019859.2.

Genome annotation databases

EnsemblFungiiSPAC19G12.15c.1; SPAC19G12.15c.1:pep; SPAC19G12.15c.
GeneIDi2542577.
KEGGispo:SPAC19G12.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242743 Genomic DNA. Translation: CAB45142.1.
CU329670 Genomic DNA. Translation: CAB10126.1.
L40359 mRNA. Translation: AAL77573.1. Frameshift.
D89225 mRNA. Translation: BAA13886.1.
PIRiT43659.
RefSeqiNP_594430.1. NM_001019859.2.

3D structure databases

ProteinModelPortaliP78875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279033. 73 interactions.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Proteomic databases

MaxQBiP78875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC19G12.15c.1; SPAC19G12.15c.1:pep; SPAC19G12.15c.
GeneIDi2542577.
KEGGispo:SPAC19G12.15c.

Organism-specific databases

EuPathDBiFungiDB:SPAC19G12.15c.
PomBaseiSPAC19G12.15c. tpp1.

Phylogenomic databases

HOGENOMiHOG000191477.
InParanoidiP78875.
KOiK16055.
OMAiEPERFIN.
OrthoDBiEOG76QFS6.
PhylomeDBiP78875.

Miscellaneous databases

NextBioi20803628.
PROiP78875.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR001830. Glyco_trans_20.
IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR003337. Trehalose_PPase.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
PF02358. Trehalose_PPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
TIGR00685. T6PP. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of tpp1(+) as encoding a main trehalose-6P phosphatase in the fission yeast Schizosaccharomyces pombe."
    Franco A., Soto T., Vicente-Soler J., Guillen P.V., Cansado J., Gacto M.
    J. Bacteriol. 182:5880-5884(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Cloning and characterization of trehalose-6-phosphate phosphatase gene in Schizosaccharomyces pombe."
    Young-Joo J., Chan-Kyu P., Hyang-Sook Y.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-817.
    Strain: 972 / ATCC 24843.
  4. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 505-817.
    Strain: PR745.

Entry informationi

Entry nameiTPP1_SCHPO
AccessioniPrimary (citable) accession number: P78875
Secondary accession number(s): Q8TGH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 1999
Last modified: May 11, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.