Skip Header

Contribute Send feedback
Read comments (?) or add your own

P78870 (FADH1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable S-(hydroxymethyl)glutathione dehydrogenase 1
EC=1.1.1.284
Alternative name(s):
Glutathione-dependent formaldehyde dehydrogenase 1
Short name=FALDH 1
Short name=FDH 1
Short name=FLD 1
Short name=GSH-FDH 1
EC=1.1.1.-
Gene names
ORF Names:SPBC1539.07c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Probable S-(hydroxymethyl)glutathione dehydrogenase 1
PRO_0000160783

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding991Zinc 2 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1131Zinc 2 By similarity
Metal binding1761Zinc 1; catalytic By similarity

Experimental info

Sequence conflict1271D → V in BAA13881. Ref.1
Sequence conflict2061G → S in BAA13881. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P78870 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 6789C07B476D1ABE

FASTA37840,444
        10         20         30         40         50         60 
MSFEGKTITC KAAVAWGAKE PLSIEDIQVA PPKAHEVRVK VDWSAVCHTD AYTLSGVDPE 

        70         80         90        100        110        120 
GAFPIVLGHE GAGIVESIGE GVINVRPGDH VILLYTPECK ECKFCRSGKT NLCSKIRETQ 

       130        140        150        160        170        180 
GRGLMPDGTS RFSCRDKTLL HYMGCSSFSQ YTVVADISLV AISHSAPLRS ICLLGCGVTT 

       190        200        210        220        230        240 
GFGAVTHSAK VESGSTVAVV GCGCVGLAAM QGAVAAGASR IIAIDINADK EVYAKKFGAT 

       250        260        270        280        290        300 
DFIDSSKVKD LVQYVIDVTD GGVDYAFDCT GNVTVMQQEL QFCHKGWGKL CVIGVAAAGK 

       310        320        330        340        350        360 
TLDFRPFLVV TGRQVLGSAF GGVKGRSELP NFVDEYMQGH FKVDEYITNE EPLKNINKAF 

       370 
DHMHEGKCIR CVVDMNKP

« Hide

References

[1]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: PR745.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D89220 mRNA. Translation: BAA13881.1.
CU329671 Genomic DNA. Translation: CAB51339.1.
PIRT39466.
RefSeqNP_596821.1. NM_001023841.1.

3D structure databases

ProteinModelPortalP78870.
SMRP78870. Positions 6-375.
ModBaseSearch...

Protein-protein interaction databases

STRINGP78870.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC1539.07c.1; SPBC1539.07c.1:pep; SPBC1539.07c.
GeneID2540073.
KEGGspo:SPBC1539.07c.
NMPDRfig|4896.1.peg.2687.

Organism-specific databases

GeneDB_SpombeSPBC1539.07c.

Phylogenomic databases

eggNOGfuNOG05232.
GeneTreeEFGT00050000001794.
HOGENOMHBG753318.
OMANPSKVEN.
OrthoDBEOG4QZBVS.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004799-MONOMER.

Gene expression databases

ArrayExpressP78870.

Family and domain databases

InterProIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00121.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 2 hits.
TIGRFAMsTIGR02818. Adh_III_F_hyde. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFADH1_SCHPO
AccessionPrimary (citable) accession number: P78870
Secondary accession number(s): Q9UUF6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: December 14, 2011
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents