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Protein

Probable S-(hydroxymethyl)glutathione dehydrogenase 1

Gene

SPBC1539.07c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalyticBy similarity
Metal bindingi69 – 691Zinc 1; catalyticBy similarity
Metal bindingi99 – 991Zinc 2By similarity
Metal bindingi102 – 1021Zinc 2By similarity
Metal bindingi105 – 1051Zinc 2By similarity
Metal bindingi113 – 1131Zinc 2By similarity
Metal bindingi176 – 1761Zinc 1; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable S-(hydroxymethyl)glutathione dehydrogenase 1 (EC:1.1.1.284)
Alternative name(s):
Glutathione-dependent formaldehyde dehydrogenase 1 (EC:1.1.1.-)
Short name:
FALDH 1
Short name:
FDH 1
Short name:
FLD 1
Short name:
GSH-FDH 1
Gene namesi
ORF Names:SPBC1539.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1539.07c.
PomBaseiSPBC1539.07c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrion Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Probable S-(hydroxymethyl)glutathione dehydrogenase 1PRO_0000160783Add
BLAST

Proteomic databases

MaxQBiP78870.

Interactioni

Protein-protein interaction databases

BioGridi276611. 2 interactions.
MINTiMINT-4691487.

Structurei

3D structure databases

ProteinModelPortaliP78870.
SMRiP78870. Positions 6-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294674.
InParanoidiP78870.
KOiK00121.
OMAiPLTMEIV.
OrthoDBiEOG75F4PS.
PhylomeDBiP78870.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFEGKTITC KAAVAWGAKE PLSIEDIQVA PPKAHEVRVK VDWSAVCHTD
60 70 80 90 100
AYTLSGVDPE GAFPIVLGHE GAGIVESIGE GVINVRPGDH VILLYTPECK
110 120 130 140 150
ECKFCRSGKT NLCSKIRETQ GRGLMPDGTS RFSCRDKTLL HYMGCSSFSQ
160 170 180 190 200
YTVVADISLV AISHSAPLRS ICLLGCGVTT GFGAVTHSAK VESGSTVAVV
210 220 230 240 250
GCGCVGLAAM QGAVAAGASR IIAIDINADK EVYAKKFGAT DFIDSSKVKD
260 270 280 290 300
LVQYVIDVTD GGVDYAFDCT GNVTVMQQEL QFCHKGWGKL CVIGVAAAGK
310 320 330 340 350
TLDFRPFLVV TGRQVLGSAF GGVKGRSELP NFVDEYMQGH FKVDEYITNE
360 370
EPLKNINKAF DHMHEGKCIR CVVDMNKP
Length:378
Mass (Da):40,444
Last modified:April 27, 2001 - v2
Checksum:i6789C07B476D1ABE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271D → V in BAA13881 (PubMed:9501991).Curated
Sequence conflicti206 – 2061G → S in BAA13881 (PubMed:9501991).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89220 mRNA. Translation: BAA13881.1.
CU329671 Genomic DNA. Translation: CAB51339.1.
PIRiT39466.
RefSeqiNP_596821.1. NM_001023841.2.

Genome annotation databases

EnsemblFungiiSPBC1539.07c.1; SPBC1539.07c.1:pep; SPBC1539.07c.
GeneIDi2540073.
KEGGispo:SPBC1539.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89220 mRNA. Translation: BAA13881.1.
CU329671 Genomic DNA. Translation: CAB51339.1.
PIRiT39466.
RefSeqiNP_596821.1. NM_001023841.2.

3D structure databases

ProteinModelPortaliP78870.
SMRiP78870. Positions 6-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276611. 2 interactions.
MINTiMINT-4691487.

Proteomic databases

MaxQBiP78870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1539.07c.1; SPBC1539.07c.1:pep; SPBC1539.07c.
GeneIDi2540073.
KEGGispo:SPBC1539.07c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1539.07c.
PomBaseiSPBC1539.07c.

Phylogenomic databases

HOGENOMiHOG000294674.
InParanoidiP78870.
KOiK00121.
OMAiPLTMEIV.
OrthoDBiEOG75F4PS.
PhylomeDBiP78870.

Enzyme and pathway databases

ReactomeiR-SPO-71384. Ethanol oxidation.

Miscellaneous databases

PROiP78870.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR014183. ADH_3.
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02818. adh_III_F_hyde. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: PR745.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiFADH1_SCHPO
AccessioniPrimary (citable) accession number: P78870
Secondary accession number(s): Q9UUF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: June 8, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.