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Protein

Lysophospholipase 1

Gene

plb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Required for survival under high osmolarity, for normal osmotic stress-induced gene expression, and for nutrient-mediated repression of sexual differentiation.1 Publication

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

GO - Biological processi

  • conjugation with cellular fusion Source: PomBase
  • osmosensory signaling pathway Source: PomBase
  • phospholipid catabolic process Source: InterPro
  • response to osmotic stress Source: UniProtKB

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 1
Gene namesi
Name:plb1
ORF Names:SPAC1A6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1A6.04c.
PomBaseiSPAC1A6.04c. plb1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • external side of plasma membrane Source: PomBase
  • extracellular region Source: PomBase
  • nucleus Source: PomBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002464022 – 613Lysophospholipase 1Add BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi551N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi572N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP78854.
PRIDEiP78854.

Interactioni

Protein-protein interaction databases

BioGridi278956. 105 interactors.
DIPiDIP-59118N.
MINTiMINT-4691450.

Structurei

3D structure databases

ProteinModelPortaliP78854.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 593PLA2cPROSITE-ProRule annotationAdd BLAST539

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi396 – 399Poly-Ser4

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiP78854.
KOiK13333.
OMAiTPPLVIY.
OrthoDBiEOG092C2IZ9.
PhylomeDBiP78854.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00022. PLAc. 1 hit.
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS51210. PLA2C. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRGLSLWM LFLASCLSAL ALPAAEDDGS VKVFKRAKKH STKQEGPSYA
60 70 80 90 100
PYYVDCPSDN IVESLSSNEI PSAESEYLST RSTITNTAMK DFLRNANLPG
110 120 130 140 150
LNADTLSGSE GPSIGIALSG GGLRAMILGS GALSAMDARH DNHTVLTGLL
160 170 180 190 200
QASDYLVGTD GSAWTVGGIA LNNFSTINDF SKLWAFNHPL MYPKSAIVFN
210 220 230 240 250
AHFYSSIMNE VAEKANAGFN ISLSDYWGRV ISRTLGDTTY GFPNVSLSSI
260 270 280 290 300
TSQEWYRNAN FPYPIITFAT QNYGEDISNV NTTFFEASPN VFGTFDHGIN
310 320 330 340 350
SFIPTEYLGT TLNNGASSNG SCVINYDNFG FMMGASSTYF NKIMRNFNDS
360 370 380 390 400
STKNGRIIQQ YLKGNFSENG QQIISIPNPF QGVESANSDA ANNLGSSSSL
410 420 430 440 450
NLVDTFLTGE KIPLWPLLQK GRDVDVIVAV DNGDDSEWLW PNGNSLVQTY
460 470 480 490 500
ERVVAAQAAG NTNVKGFPYV PSQQSFVSLH FNDRPVFFGC DGRNTTAGNH
510 520 530 540 550
TVTRDTPPLV IYLPNVPYNY FTNISTDRTY YTEDMIQQLL TNGLISSTVD
560 570 580 590 600
NDTYFGQCFA CAVVKRTLER NNITASPECQ QCYYNYCWSG LYDDSAANDD
610
IVYNPTCRLG EGI
Length:613
Mass (Da):67,119
Last modified:November 1, 1998 - v2
Checksum:iEE7C8B5D78A8FFFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY235223 mRNA. Translation: AAO46159.1.
CU329670 Genomic DNA. Translation: CAB16354.1.
AB005603 mRNA. Translation: BAA21498.1.
D89204 mRNA. Translation: BAA13865.1.
PIRiT38007.
RefSeqiNP_593196.1. NM_001018592.2.

Genome annotation databases

EnsemblFungiiSPAC1A6.04c.1; SPAC1A6.04c.1:pep; SPAC1A6.04c.
GeneIDi2542497.
KEGGispo:SPAC1A6.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY235223 mRNA. Translation: AAO46159.1.
CU329670 Genomic DNA. Translation: CAB16354.1.
AB005603 mRNA. Translation: BAA21498.1.
D89204 mRNA. Translation: BAA13865.1.
PIRiT38007.
RefSeqiNP_593196.1. NM_001018592.2.

3D structure databases

ProteinModelPortaliP78854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278956. 105 interactors.
DIPiDIP-59118N.
MINTiMINT-4691450.

Proteomic databases

MaxQBiP78854.
PRIDEiP78854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1A6.04c.1; SPAC1A6.04c.1:pep; SPAC1A6.04c.
GeneIDi2542497.
KEGGispo:SPAC1A6.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC1A6.04c.
PomBaseiSPAC1A6.04c. plb1.

Phylogenomic databases

HOGENOMiHOG000189547.
InParanoidiP78854.
KOiK13333.
OMAiTPPLVIY.
OrthoDBiEOG092C2IZ9.
PhylomeDBiP78854.

Miscellaneous databases

PROiPR:P78854.

Family and domain databases

InterProiView protein in InterPro
IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
PfamiView protein in Pfam
PF01735. PLA2_B. 1 hit.
SMARTiView protein in SMART
SM00022. PLAc. 1 hit.
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiView protein in PROSITE
PS51210. PLA2C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLB1_SCHPO
AccessioniPrimary (citable) accession number: P78854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: June 7, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.