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P78854

- PLB1_SCHPO

UniProt

P78854 - PLB1_SCHPO

Protein

Lysophospholipase 1

Gene

plb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the release of fatty acids from lysophospholipids. Required for survival under high osmolarity, for normal osmotic stress-induced gene expression, and for nutrient-mediated repression of sexual differentiation.1 Publication

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    GO - Molecular functioni

    1. lysophospholipase activity Source: PomBase

    GO - Biological processi

    1. cellular response to nutrient Source: PomBase
    2. cellular response to osmotic stress Source: PomBase
    3. glycerophospholipid catabolic process Source: PomBase
    4. negative regulation of conjugation with cellular fusion Source: PomBase
    5. response to osmotic stress Source: UniProtKB
    6. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase 1 (EC:3.1.1.5)
    Alternative name(s):
    Phospholipase B 1
    Gene namesi
    Name:plb1
    ORF Names:SPAC1A6.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC1A6.04c.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. external side of plasma membrane Source: PomBase
    3. extracellular region Source: UniProtKB-SubCell
    4. fungal-type cell wall Source: PomBase
    5. nucleus Source: PomBase

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 613592Lysophospholipase 1PRO_0000024640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi319 – 3191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi523 – 5231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi551 – 5511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP78854.
    PaxDbiP78854.

    Interactioni

    Protein-protein interaction databases

    BioGridi278956. 107 interactions.
    DIPiDIP-59118N.
    MINTiMINT-4691450.
    STRINGi4896.SPAC1A6.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP78854.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 593539PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi396 – 3994Poly-Ser

    Sequence similaritiesi

    Belongs to the lysophospholipase family.Curated
    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG257248.
    HOGENOMiHOG000189547.
    KOiK13333.
    OMAiPGPSGEY.
    OrthoDBiEOG7N37NC.
    PhylomeDBiP78854.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P78854-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFRGLSLWM LFLASCLSAL ALPAAEDDGS VKVFKRAKKH STKQEGPSYA    50
    PYYVDCPSDN IVESLSSNEI PSAESEYLST RSTITNTAMK DFLRNANLPG 100
    LNADTLSGSE GPSIGIALSG GGLRAMILGS GALSAMDARH DNHTVLTGLL 150
    QASDYLVGTD GSAWTVGGIA LNNFSTINDF SKLWAFNHPL MYPKSAIVFN 200
    AHFYSSIMNE VAEKANAGFN ISLSDYWGRV ISRTLGDTTY GFPNVSLSSI 250
    TSQEWYRNAN FPYPIITFAT QNYGEDISNV NTTFFEASPN VFGTFDHGIN 300
    SFIPTEYLGT TLNNGASSNG SCVINYDNFG FMMGASSTYF NKIMRNFNDS 350
    STKNGRIIQQ YLKGNFSENG QQIISIPNPF QGVESANSDA ANNLGSSSSL 400
    NLVDTFLTGE KIPLWPLLQK GRDVDVIVAV DNGDDSEWLW PNGNSLVQTY 450
    ERVVAAQAAG NTNVKGFPYV PSQQSFVSLH FNDRPVFFGC DGRNTTAGNH 500
    TVTRDTPPLV IYLPNVPYNY FTNISTDRTY YTEDMIQQLL TNGLISSTVD 550
    NDTYFGQCFA CAVVKRTLER NNITASPECQ QCYYNYCWSG LYDDSAANDD 600
    IVYNPTCRLG EGI 613
    Length:613
    Mass (Da):67,119
    Last modified:November 1, 1998 - v2
    Checksum:iEE7C8B5D78A8FFFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY235223 mRNA. Translation: AAO46159.1.
    CU329670 Genomic DNA. Translation: CAB16354.1.
    AB005603 mRNA. Translation: BAA21498.1.
    D89204 mRNA. Translation: BAA13865.1.
    PIRiT38007.
    RefSeqiNP_593196.1. NM_001018592.2.

    Genome annotation databases

    EnsemblFungiiSPAC1A6.04c.1; SPAC1A6.04c.1:pep; SPAC1A6.04c.
    GeneIDi2542497.
    KEGGispo:SPAC1A6.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY235223 mRNA. Translation: AAO46159.1 .
    CU329670 Genomic DNA. Translation: CAB16354.1 .
    AB005603 mRNA. Translation: BAA21498.1 .
    D89204 mRNA. Translation: BAA13865.1 .
    PIRi T38007.
    RefSeqi NP_593196.1. NM_001018592.2.

    3D structure databases

    ProteinModelPortali P78854.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278956. 107 interactions.
    DIPi DIP-59118N.
    MINTi MINT-4691450.
    STRINGi 4896.SPAC1A6.04c-1.

    Proteomic databases

    MaxQBi P78854.
    PaxDbi P78854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC1A6.04c.1 ; SPAC1A6.04c.1:pep ; SPAC1A6.04c .
    GeneIDi 2542497.
    KEGGi spo:SPAC1A6.04c.

    Organism-specific databases

    PomBasei SPAC1A6.04c.

    Phylogenomic databases

    eggNOGi NOG257248.
    HOGENOMi HOG000189547.
    KOi K13333.
    OMAi PGPSGEY.
    OrthoDBi EOG7N37NC.
    PhylomeDBi P78854.

    Miscellaneous databases

    NextBioi 20803551.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe."
      Yang P., Du H., Hoffman C.S., Marcus S.
      Mol. Genet. Genomics 269:116-125(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "S.pombe phospholipase B homolog."
      Kawamukai M.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-613.
    4. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-613.
      Strain: PR745.

    Entry informationi

    Entry nameiPLB1_SCHPO
    AccessioniPrimary (citable) accession number: P78854
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3