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P78854

- PLB1_SCHPO

UniProt

P78854 - PLB1_SCHPO

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Protein
Lysophospholipase 1
Gene
plb1, SPAC1A6.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Required for survival under high osmolarity, for normal osmotic stress-induced gene expression, and for nutrient-mediated repression of sexual differentiation.1 Publication

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: PomBase

GO - Biological processi

  1. cellular response to nutrient Source: PomBase
  2. cellular response to osmotic stress Source: PomBase
  3. glycerophospholipid catabolic process Source: PomBase
  4. negative regulation of conjugation with cellular fusion Source: PomBase
  5. response to osmotic stress Source: UniProtKB
  6. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 1 (EC:3.1.1.5)
Alternative name(s):
Phospholipase B 1
Gene namesi
Name:plb1
ORF Names:SPAC1A6.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1A6.04c.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. external side of plasma membrane Source: PomBase
  3. extracellular region Source: UniProtKB-SubCell
  4. fungal-type cell wall Source: PomBase
  5. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 613592Lysophospholipase 1
PRO_0000024640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi319 – 3191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi348 – 3481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi494 – 4941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi499 – 4991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi523 – 5231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi551 – 5511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP78854.
PaxDbiP78854.

Interactioni

Protein-protein interaction databases

BioGridi278956. 107 interactions.
DIPiDIP-59118N.
MINTiMINT-4691450.
STRINGi4896.SPAC1A6.04c-1.

Structurei

3D structure databases

ProteinModelPortaliP78854.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 593539PLA2c
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi396 – 3994Poly-Ser

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG257248.
HOGENOMiHOG000189547.
KOiK13333.
OMAiPGPSGEY.
OrthoDBiEOG7N37NC.
PhylomeDBiP78854.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P78854-1 [UniParc]FASTAAdd to Basket

« Hide

MLFRGLSLWM LFLASCLSAL ALPAAEDDGS VKVFKRAKKH STKQEGPSYA    50
PYYVDCPSDN IVESLSSNEI PSAESEYLST RSTITNTAMK DFLRNANLPG 100
LNADTLSGSE GPSIGIALSG GGLRAMILGS GALSAMDARH DNHTVLTGLL 150
QASDYLVGTD GSAWTVGGIA LNNFSTINDF SKLWAFNHPL MYPKSAIVFN 200
AHFYSSIMNE VAEKANAGFN ISLSDYWGRV ISRTLGDTTY GFPNVSLSSI 250
TSQEWYRNAN FPYPIITFAT QNYGEDISNV NTTFFEASPN VFGTFDHGIN 300
SFIPTEYLGT TLNNGASSNG SCVINYDNFG FMMGASSTYF NKIMRNFNDS 350
STKNGRIIQQ YLKGNFSENG QQIISIPNPF QGVESANSDA ANNLGSSSSL 400
NLVDTFLTGE KIPLWPLLQK GRDVDVIVAV DNGDDSEWLW PNGNSLVQTY 450
ERVVAAQAAG NTNVKGFPYV PSQQSFVSLH FNDRPVFFGC DGRNTTAGNH 500
TVTRDTPPLV IYLPNVPYNY FTNISTDRTY YTEDMIQQLL TNGLISSTVD 550
NDTYFGQCFA CAVVKRTLER NNITASPECQ QCYYNYCWSG LYDDSAANDD 600
IVYNPTCRLG EGI 613
Length:613
Mass (Da):67,119
Last modified:November 1, 1998 - v2
Checksum:iEE7C8B5D78A8FFFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY235223 mRNA. Translation: AAO46159.1.
CU329670 Genomic DNA. Translation: CAB16354.1.
AB005603 mRNA. Translation: BAA21498.1.
D89204 mRNA. Translation: BAA13865.1.
PIRiT38007.
RefSeqiNP_593196.1. NM_001018592.2.

Genome annotation databases

EnsemblFungiiSPAC1A6.04c.1; SPAC1A6.04c.1:pep; SPAC1A6.04c.
GeneIDi2542497.
KEGGispo:SPAC1A6.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY235223 mRNA. Translation: AAO46159.1 .
CU329670 Genomic DNA. Translation: CAB16354.1 .
AB005603 mRNA. Translation: BAA21498.1 .
D89204 mRNA. Translation: BAA13865.1 .
PIRi T38007.
RefSeqi NP_593196.1. NM_001018592.2.

3D structure databases

ProteinModelPortali P78854.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278956. 107 interactions.
DIPi DIP-59118N.
MINTi MINT-4691450.
STRINGi 4896.SPAC1A6.04c-1.

Proteomic databases

MaxQBi P78854.
PaxDbi P78854.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1A6.04c.1 ; SPAC1A6.04c.1:pep ; SPAC1A6.04c .
GeneIDi 2542497.
KEGGi spo:SPAC1A6.04c.

Organism-specific databases

PomBasei SPAC1A6.04c.

Phylogenomic databases

eggNOGi NOG257248.
HOGENOMi HOG000189547.
KOi K13333.
OMAi PGPSGEY.
OrthoDBi EOG7N37NC.
PhylomeDBi P78854.

Miscellaneous databases

NextBioi 20803551.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe."
    Yang P., Du H., Hoffman C.S., Marcus S.
    Mol. Genet. Genomics 269:116-125(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "S.pombe phospholipase B homolog."
    Kawamukai M.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-613.
  4. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
    Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
    DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-613.
    Strain: PR745.

Entry informationi

Entry nameiPLB1_SCHPO
AccessioniPrimary (citable) accession number: P78854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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