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P78854 (PLB1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 1

EC=3.1.1.5
Alternative name(s):
Phospholipase B 1
Gene names
Name:plb1
ORF Names:SPAC1A6.04c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids. Required for survival under high osmolarity, for normal osmotic stress-induced gene expression, and for nutrient-mediated repression of sexual differentiation. Ref.1

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 613592Lysophospholipase 1
PRO_0000024640

Regions

Domain55 – 593539PLA2c
Compositional bias396 – 3994Poly-Ser

Amino acid modifications

Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation3191N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation4941N-linked (GlcNAc...) Potential
Glycosylation4991N-linked (GlcNAc...) Potential
Glycosylation5231N-linked (GlcNAc...) Potential
Glycosylation5511N-linked (GlcNAc...) Potential
Glycosylation5721N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P78854 [UniParc].

Last modified November 1, 1998. Version 2.
Checksum: EE7C8B5D78A8FFFD

FASTA61367,119
        10         20         30         40         50         60 
MLFRGLSLWM LFLASCLSAL ALPAAEDDGS VKVFKRAKKH STKQEGPSYA PYYVDCPSDN 

        70         80         90        100        110        120 
IVESLSSNEI PSAESEYLST RSTITNTAMK DFLRNANLPG LNADTLSGSE GPSIGIALSG 

       130        140        150        160        170        180 
GGLRAMILGS GALSAMDARH DNHTVLTGLL QASDYLVGTD GSAWTVGGIA LNNFSTINDF 

       190        200        210        220        230        240 
SKLWAFNHPL MYPKSAIVFN AHFYSSIMNE VAEKANAGFN ISLSDYWGRV ISRTLGDTTY 

       250        260        270        280        290        300 
GFPNVSLSSI TSQEWYRNAN FPYPIITFAT QNYGEDISNV NTTFFEASPN VFGTFDHGIN 

       310        320        330        340        350        360 
SFIPTEYLGT TLNNGASSNG SCVINYDNFG FMMGASSTYF NKIMRNFNDS STKNGRIIQQ 

       370        380        390        400        410        420 
YLKGNFSENG QQIISIPNPF QGVESANSDA ANNLGSSSSL NLVDTFLTGE KIPLWPLLQK 

       430        440        450        460        470        480 
GRDVDVIVAV DNGDDSEWLW PNGNSLVQTY ERVVAAQAAG NTNVKGFPYV PSQQSFVSLH 

       490        500        510        520        530        540 
FNDRPVFFGC DGRNTTAGNH TVTRDTPPLV IYLPNVPYNY FTNISTDRTY YTEDMIQQLL 

       550        560        570        580        590        600 
TNGLISSTVD NDTYFGQCFA CAVVKRTLER NNITASPECQ QCYYNYCWSG LYDDSAANDD 

       610 
IVYNPTCRLG EGI 

« Hide

References

« Hide 'large scale' references
[1]"The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe."
Yang P., Du H., Hoffman C.S., Marcus S.
Mol. Genet. Genomics 269:116-125(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"S.pombe phospholipase B homolog."
Kawamukai M.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 294-613.
[4]"Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 338-613.
Strain: PR745.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY235223 mRNA. Translation: AAO46159.1.
CU329670 Genomic DNA. Translation: CAB16354.1.
AB005603 mRNA. Translation: BAA21498.1.
D89204 mRNA. Translation: BAA13865.1.
PIRT38007.
RefSeqNP_593196.1. NM_001018592.2.

3D structure databases

ProteinModelPortalP78854.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid278956. 107 interactions.
DIPDIP-59118N.
MINTMINT-4691450.
STRING4896.SPAC1A6.04c-1.

Proteomic databases

PaxDbP78854.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC1A6.04c.1; SPAC1A6.04c.1:pep; SPAC1A6.04c.
GeneID2542497.
KEGGspo:SPAC1A6.04c.

Organism-specific databases

PomBaseSPAC1A6.04c.

Phylogenomic databases

eggNOGNOG257248.
HOGENOMHOG000189547.
KOK13333.
OMAPGPSGEY.
OrthoDBEOG7N37NC.
PhylomeDBP78854.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803551.

Entry information

Entry namePLB1_SCHPO
AccessionPrimary (citable) accession number: P78854
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names