P78825 (ADK_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosine kinase
EC=2.7.1.20

Gene names

Name:	ado1
ORF Names:	SPCC338.14

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + adenosine = ADP + AMP.
Cofactor	Magnesium By similarity.
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.
Sequence similarities	Belongs to the carbohydrate kinase pfkB family.

Ontologies

Keywords
Biological process	Purine salvage
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenosine salvage Inferred by curator. Source: GeneDB_Spombe purine base metabolic process Inferred from sequence or structural similarity. Source: GeneDB_Spombe
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_Spombe nucleus Inferred from direct assay. Source: GeneDB_Spombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenosine kinase activity Inferred from sequence or structural similarity. Source: GeneDB_Spombe phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Adenosine kinase		PRO_0000080061
Sites
	Active site	292	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P78825 [UniParc]. Last modified August 31, 2004. Version 2. Checksum: 751F55FF68F410EF	FASTA	340	36,709
	10 20 30 40 50 60 MSSYILFGLE NPLLDYYVGG ETATLEKYGL KSNDAVLASE SQMGIYKEPC VSYSAGGAAQ 70 80 90 100 110 120 NSCRAAQYVL PPNSTVFAGC VGQDKFADML LESNEKAGLR SEFSVDPTTP TGVCAVVLSN 130 140 150 160 170 180 NNKNRSLCTN LGAANNYKLK DLQQPNVWKF VEEAKVIYVG GFHLTVSPES MLCLAQHANE 190 200 210 220 230 240 NNKPYIMNLS APFLSQFFKE QMDSVIPYCD YVIGNEAEIL SYGENHGIKS TDVQEIALAL 250 260 270 280 290 300 SSVEKVNKKR TRVVVITQGA DATIVAKDGK VTTYKPNRVP SEEIVDTNGA GDAFAGGFIA 310 320 330 340 ALSQGQGIDY AVTLGHWLGQ ECIKVSGTTL PLPKKQFPLP

References

[1]	"Identification of open reading frames in Schizosaccharomyces pombe cDNAs." Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H. DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: PR745.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D89173 mRNA. Translation: BAA13835.1. CU329672 Genomic DNA. Translation: CAA19345.2.
PIR	T41729. T42538.
RefSeq	NP_588154.1. NM_001023143.1.
3D structure databases
ProteinModelPortal	P78825.
ModBase	Search...
Protein-protein interaction databases
STRING	P78825.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC338.14.1; SPCC338.14.1:pep; SPCC338.14.
GeneID	2539129.
GenomeReviews	Gene locus ado1 in contig CU329672_GR.
KEGG	spo:SPCC338.14.
NMPDR	fig|4896.1.peg.492.
Organism-specific databases
GeneDB_Spombe	SPCC338.14.
Phylogenomic databases
eggNOG	fuNOG07084.
GeneTree	EFGT00050000002260.
HOGENOM	HBG314716.
OMA	AQWMIQQ.
OrthoDB	EOG4004T0.
Gene expression databases
ArrayExpress	P78825.
Family and domain databases
InterPro	IPR001805. Adenokinase. IPR011611. Carb/pur_kinase. IPR002173. Carboh/pur_kinase_PfkB_CS. [Graphical view]
KO	K00856.
PANTHER	PTHR10584:SF24. Adenokinase. 1 hit.
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PRINTS	PR00989. ADENOKINASE.
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADK_SCHPO

Accession

Primary (citable) accession number: P78825
Secondary accession number(s): Q76PD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	December 14, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program