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Protein

Pre-mRNA-splicing factor srp2

Gene

srp2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in pre-mRNA splicing where it is involved in spliceosome assembly.By similarity

GO - Molecular functioni

  • mRNA binding Source: PomBase
  • nucleotide binding Source: InterPro
  • poly(A) binding Source: PomBase
  • regulatory region RNA binding Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor srp2
Gene namesi
Name:srp2
ORF Names:SPAC16.02c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16.02c.
PomBaseiSPAC16.02c. srp2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Pre-mRNA-splicing factor srp2PRO_0000081963Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei186 – 1861Phosphoserine1 Publication
Modified residuei188 – 1881Phosphoserine1 Publication
Modified residuei276 – 2761Phosphoserine1 Publication
Modified residuei294 – 2941Phosphoserine1 Publication
Modified residuei296 – 2961Phosphoserine1 Publication
Modified residuei298 – 2981Phosphoserine1 Publication
Modified residuei308 – 3081Phosphoserine1 Publication

Post-translational modificationi

Extensively phosphorylated on serine residues in the RS domain.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP78814.

PTM databases

iPTMnetiP78814.

Interactioni

Protein-protein interaction databases

BioGridi279221. 20 interactions.

Structurei

3D structure databases

ProteinModelPortaliP78814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6964RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini100 – 16667RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi74 – 9118Gly-rich (hinge region)Add
BLAST
Compositional biasi182 – 300119Arg/Ser-rich (RS domain)Add
BLAST

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP78814.
KOiK12893.
OMAiKCTDETR.
OrthoDBiEOG092C5ATD.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P78814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETRLFVGR IPPQATREDM MDFFKGYGQI LDCKLMNGFG FVEVEDARDA
60 70 80 90 100
RDIVNDFQGK EFMGSRIVVE PARGERRRRE NFRESAASKY PRPRRTGFRL
110 120 130 140 150
IVENLSEDVS WQDLKDVMRK AGEPTFTDAH RENPGAGVVE FSTEEDMRNA
160 170 180 190 200
LTSLNGEVIK GQAVTLREDP DAANEPLPEV PSRFRSRSPP ARRRYRDDYR
210 220 230 240 250
RGGDYRRDAY RPGRDDERRY APRGEYRRNN RDEYRRGGRD EYRRNSRSDY
260 270 280 290 300
RRPHDDEYRR PRGDEYRPGR DEYRRSRDDG RPSHDDEYRR DAYSRSPSPR
310 320 330 340 350
RDREENRSPA YEGSKSYSAA PEASMESSAP TESYDKPAAS EEQQPLQNHS
360
DVGNGSAEGQ VAAEW
Length:365
Mass (Da):42,566
Last modified:November 1, 1998 - v2
Checksum:i67E988573A736691
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012278 Genomic DNA. Translation: AAC39357.1.
CU329670 Genomic DNA. Translation: CAB57400.1.
D89163 mRNA. Translation: BAA13825.1.
PIRiT37730.
T42525.
RefSeqiNP_594570.1. NM_001019999.2.

Genome annotation databases

EnsemblFungiiSPAC16.02c.1; SPAC16.02c.1:pep; SPAC16.02c.
GeneIDi2542772.
KEGGispo:SPAC16.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012278 Genomic DNA. Translation: AAC39357.1.
CU329670 Genomic DNA. Translation: CAB57400.1.
D89163 mRNA. Translation: BAA13825.1.
PIRiT37730.
T42525.
RefSeqiNP_594570.1. NM_001019999.2.

3D structure databases

ProteinModelPortaliP78814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279221. 20 interactions.

PTM databases

iPTMnetiP78814.

Proteomic databases

MaxQBiP78814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC16.02c.1; SPAC16.02c.1:pep; SPAC16.02c.
GeneIDi2542772.
KEGGispo:SPAC16.02c.

Organism-specific databases

EuPathDBiFungiDB:SPAC16.02c.
PomBaseiSPAC16.02c. srp2.

Phylogenomic databases

InParanoidiP78814.
KOiK12893.
OMAiKCTDETR.
OrthoDBiEOG092C5ATD.

Enzyme and pathway databases

ReactomeiR-SPO-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiP78814.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRP2_SCHPO
AccessioniPrimary (citable) accession number: P78814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.